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Chromosome Aberrations (Chromosome Abnormalities)

Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
Also Known As:
Chromosome Abnormalities; Chromosomal Abnormalities; Abnormalities, Chromosome; Chromosomal Aberrations; Chromosomal Abnormality; Chromosome Aberration; Abnormalities, Autosome; Abnormalities, Chromosomal; Cytogenetic Abnormalities; Aberration, Chromosomal; Aberration, Chromosome; Aberration, Cytogenetic; Aberrations, Chromosomal; Aberrations, Chromosome; Aberrations, Cytogenetic; Abnormalities, Cytogenetic; Abnormality, Autosome; Abnormality, Chromosomal; Abnormality, Chromosome; Abnormality, Cytogenetic; Autosome Abnormality; Chromosomal Aberration; Chromosome Abnormality; Cytogenetic Aberration; Cytogenetic Abnormality; Autosome Abnormalities; Cytogenetic Aberrations
Networked: 11361 relevant articles (302 outcomes, 1236 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
3. Leukemia
4. Myelodysplastic Syndromes (Myelodysplastic Syndrome)
5. B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)

Experts

1. Bolzán, Alejandro D: 22 articles (08/2021 - 06/2002)
2. Barlogie, Bart: 19 articles (06/2013 - 08/2002)
3. Liehr, Thomas: 18 articles (11/2021 - 04/2004)
4. Xu, Wei: 18 articles (01/2020 - 10/2006)
5. Unal, Fatma: 17 articles (11/2022 - 03/2005)
6. Garcia-Manero, Guillermo: 17 articles (01/2022 - 05/2002)
7. Li, Jian-Yong: 17 articles (01/2020 - 10/2006)
8. Kaina, Bernd: 17 articles (12/2016 - 01/2002)
9. Afzal, Mohammad: 17 articles (01/2016 - 07/2002)
10. Natarajan, A T: 17 articles (08/2013 - 02/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chromosome Aberrations:
1. DNA (Deoxyribonucleic Acid)IBA
2. Lenalidomide (CC 5013)FDA Link
3. Biomarkers (Surrogate Marker)IBA
4. Cyclophosphamide (Cytoxan)FDA LinkGeneric
5. dichlorobis(azomycin)platinum IIIBA
6. AntioxidantsIBA
7. Ascorbic Acid (Vitamin C)FDA LinkGeneric
8. Bleomycin (Blenoxane)FDA LinkGeneric
9. Imatinib Mesylate (Gleevec)FDA Link
10. Cytarabine (Cytosar-U)FDA LinkGeneric

Therapies and Procedures

1. Therapeutics
08/01/2020 - "Treated with standard therapy, adult CBF AML has higher complete remission (CR) rate, longer CR duration, and better prognosis than that of AML patients with normal karyotype or other chromosomal aberrations. "
01/01/2020 - "The median age for the targeted therapy cohort was 60 years (range, 30-71 years), and 20% and 73% had complete and partial remission, respectively: 76% had del(17p), 46.2% had 5 or more cytogenetic abnormalities, and 78.9% were IGHV unmutated. "
01/22/2016 - "Together with cytogenetic aberrations, these gene mutations are powerful prognostic markers in AML and can be used to guide patient management, for example selection of optimal post-remission therapy. "
01/01/2006 - "Biological features at presentation [gender, age, white blood cells, platelet count, French-American-British (FAB) subtypes, cytogenetic abnormalities] and therapy-related factors [bone marrow (BM) blast cell counts at 48 h after the first induction course, complete remission (CR) rate after the first course of induction therapy] were analyzed. "
01/01/1994 - "The ineffectiveness of ATRA may be dut to different pathological conditions from de novo APL, or progressive reduction in plasma ATRA concentration as reported by Muindi et al. When our case was compared with a similar case reported by Wiernick et al., both cases were treated with IFN alpha in the chronic phases, had no t(15;17) translocation involving No.1 chromosome abnormality and did not develop complete remission after ATRA therapy."
2. Drug Therapy (Chemotherapy)
3. Induction Chemotherapy
4. Aftercare (After-Treatment)
5. Stem Cell Transplantation