Anti-asthmatic effect of marine red alga (Laurencia undulata) polyphenolic extracts in a murine model of asthma.

Abstract

The aim of the present work is focused on protective effects of an edible red alga, Laurencia undulata ethanolic (EtOH) extracts (LU) containing a large amount of polyphenols against OVA-induced murine allergic airway reactions using in vivo histological and cytokine assay. Mice sensitized and challenged with ovalbumin (OVA) showed typical asthmatic reactions as follows: an increase in the number of eosinophil in bronchoalveolar lavage fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways, and airway luminal narrowing; the development of airway hyperresponsiveness; the detection of TNF-alpha and Th2 cytokines, such as IL-4 and IL-5 in the bronchoalveolar lavage (BAL) fluid; and detection of allergen-specific IgE in the serum. The successive intraperitoneal administration of LU before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These results suggest that L. undulata polyphenolic extracts possess therapeutic potential for combating bronchial asthma associated with allergic diseases.

• Authors: Won-Kyo Jung, Inhak Choi, Sangtaek Oh, Sae-Gwang Park, Su-Kil Seo, Soo-Woong Lee, Dae-Sung Lee, Soo-Jin Heo, You-Jin Jeon, Jae-Young Je, Chang-Bum Ahn, Jin Soo Kim, Kwang Soo Oh, Young-Mog Kim, Chisook Moon, Il-Whan Choi
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 47 Issue 2 Pg. 293-7 (Feb 2009) ISSN: 1873-6351 [Electronic] England
• PMID: 19049817 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Asthmatic Agents
• Cytokines
• Flavonoids
• Phenols
• Plant Extracts
• Polyphenols
• Ovalbumin

Topics

• Animals
• Anti-Asthmatic Agents (pharmacology)
• Asthma (drug therapy, immunology, physiopathology)
• Bronchial Hyperreactivity (drug therapy, immunology, physiopathology)
• Bronchoalveolar Lavage Fluid (chemistry, cytology)
• Cytokines (analysis, metabolism)
• Disease Models, Animal
• Female
• Flavonoids (pharmacology)
• Laurencia (chemistry)
• Lung (drug effects, pathology)
• Mice
• Mice, Inbred C57BL
• Ovalbumin (immunology)
• Phenols (pharmacology)
• Plant Extracts (pharmacology)
• Polyphenols