Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women.

Abstract

OBJECTIVE:

The objective of this study was to determine whether total serum carotenoids, alpha-tocopherol, selenium, and obesity were independently associated with oxidized low-density lipoproteins (ox-LDLs) in moderately to severely disabled older women living in the community.

METHODS:

Serum ox-LDLs, carotenoids, alpha-tocopherol, and selenium were measured in a population-based sample of 543 moderately to severely disabled women > or = 65 y in the Women's Health and Aging Study I in Baltimore, Maryland.

RESULTS:

Total serum carotenoids, smoking, overweight (body mass index 25-29.9 kg/m(2)), and obesity (body mass index > or = 30 mg/kg(2)) were significantly associated with the ox-LDL/LDL cholesterol ratio after adjusting for age, C-reactive protein, and chronic diseases. alpha-Tocopherol and selenium were not significantly associated with the ox-LDL/LDL cholesterol ratio.

CONCLUSION:

Older women who are overweight or obese or who have low total serum carotenoids are more likely to have higher lipoprotein oxidation. Weight reduction in overweight/obese women and increased intake of carotenoid-rich foods may potentially reduce lipoprotein oxidation.

• Authors: Justine Beck, Luigi Ferrucci, Kai Sun, Linda P Fried, Ravi Varadhan, Jeremy Walston, Jack M Guralnik, Richard D Semba
• Journal: Nutrition (Burbank, Los Angeles County, Calif.) (Nutrition) Vol. 24 Issue 10 Pg. 964-8 (Oct 2008) ISSN: 0899-9007 [Print] United States
• PMID: 18585897 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)

Chemical References

• Lipoproteins, LDL
• oxidized low density lipoprotein
• Carotenoids
• alpha-Tocopherol
• Selenium

Topics

• Aged
• Aging (blood)
• Body Mass Index
• Carotenoids (blood)
• Female
• Humans
• Lipoproteins, LDL (blood)
• Nutritional Requirements
• Nutritional Status
• Obesity (blood)
• Overweight (blood)
• Oxidation-Reduction
• Selenium (blood)
• alpha-Tocopherol (blood)