Abstract | BACKGROUND: METHODS: Male adult ZFRs (N = 19) and their lean littermates (N = 18) were studied. Periodontitis was induced with ligatures in half of the ZFRs and lean rats, whereas the other half served as controls. After 4 weeks, the rats were sacrificed, and the kidneys, liver, and heart were removed and weighed. Kidneys were evaluated histologically for glomerular volume and renal mRNA levels of vascular endothelial growth factor ( VEGF), VEGF receptor 2, transforming growth factor-beta, connective tissue growth factor, collagen IValpha1, fibronectin, and nephrin. Urinary albumin excretion and creatinine clearance were also evaluated. RESULTS: CONCLUSION: Our findings suggest the participation of periodontitis in the development of early renal changes in ZFRs.
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Authors | Carla C Pontes Andersen, Palle Holmstrup, Karsten Buschard, Allan Flyvbjerg |
Journal | Journal of periodontology
(J Periodontol)
Vol. 79
Issue 4
Pg. 684-90
(Apr 2008)
ISSN: 0022-3492 [Print] United States |
PMID | 18380562
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CCN2 protein, rat
- Collagen Type IV
- Fibronectins
- Immediate-Early Proteins
- Insulin-Like Growth Factor Binding Proteins
- Intercellular Signaling Peptides and Proteins
- Membrane Proteins
- RNA, Messenger
- Transforming Growth Factor beta
- Vascular Endothelial Growth Factor A
- nephrin
- vascular endothelial growth factor A, rat
- Connective Tissue Growth Factor
- Creatinine
- Vascular Endothelial Growth Factor Receptor-2
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Topics |
- Albuminuria
(urine)
- Animals
- Collagen Type IV
(analysis)
- Connective Tissue Growth Factor
- Creatinine
(urine)
- Fibronectins
(analysis)
- Hypertrophy
- Immediate-Early Proteins
(analysis)
- Insulin-Like Growth Factor Binding Proteins
(analysis)
- Intercellular Signaling Peptides and Proteins
(analysis)
- Kidney
(pathology, physiopathology)
- Kidney Diseases
(etiology, physiopathology)
- Kidney Glomerulus
(pathology)
- Male
- Membrane Proteins
(analysis)
- Organ Size
- Periodontitis
(complications)
- Prediabetic State
(complications)
- RNA, Messenger
(analysis)
- Random Allocation
- Rats
- Rats, Zucker
- Transforming Growth Factor beta
(analysis)
- Vascular Endothelial Growth Factor A
(analysis)
- Vascular Endothelial Growth Factor Receptor-2
(analysis)
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