A growing amount of attention has been focused on the investigation of the effects of chemopreventive agents on the inhibition of
cancer cell growth and toxicity in combination with chemotherapeutics. The objective of this study was to determine whether
isoliquiritigenin (ISL) has the potential to serve as a beneficial supplement during
cisplatin chemotherapy. We found that the administration of ISL alone significantly reduced the size of the solid
tumors in CT-26 cell-inoculated BALB/c mice, without any detectable induction of nephrotoxicity, hepatotoxicity, and oxidative stress, and ISL reduced the viability and
DNA synthesis of CT-26 murine
colon cancer cells in a dose-dependent manner. ISL did not affect the therapeutic efficacy of
cisplatin. Furthermore, ISL suppressed
cisplatin-induced kidney damage characterized by increases in serum
creatinine and blood
urea nitrogen, as well as
cisplatin-induced liver damage characterized by increases in serum
alanine aminotransferase and
aspartate aminotransferase. The repeated
oral administration of ISL prior to
cisplatin treatment exerted a preventive effect on
cisplatin-mediated increases in serum
nitric oxide and tissue lipid peroxidation levels, and it recovered depleted GSH levels in the tissues. Therefore, supplementation with ISL may be an effective approach to counteracting the side effects of
cisplatin therapy in
cancer patients.