Abstract | BACKGROUND: METHODS: RESULTS: The mean weight, body mass index, and waist circumference increased significantly from baseline to Month 12 (P < .001 for each comparison). Fat mass increased by 11.2% +/- 1.5% (P < .001) and the percentage lean body mass decreased by 3.6% +/- 0.5% (P < .001). The total abdominal fat area increased by 16.5% +/- 2.6% (P < .001), with the accumulation of subcutaneous fat accounting for 94% of the observed increase. The waist-to-hip ratio and blood pressure did not change significantly. Serum high-density lipoprotein ( HDL) cholesterol concentrations increased significantly (P = .002). Serum adiponectin levels increased by 36.4 +/- 5.9% from baseline to Month 3 and remained significantly elevated through Month 12 (P < .001). Resistin and C-reactive protein levels did not change significantly. CONCLUSIONS:
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Authors | Matthew R Smith, Hang Lee, Francis McGovern, Mary Anne Fallon, Melissa Goode, Anthony L Zietman, Joel S Finkelstein |
Journal | Cancer
(Cancer)
Vol. 112
Issue 10
Pg. 2188-94
(May 15 2008)
ISSN: 0008-543X [Print] United States |
PMID | 18348297
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2008 American Cancer Society. |
Chemical References |
- Adiponectin
- Antineoplastic Agents, Hormonal
- Lipids
- Gonadotropin-Releasing Hormone
- C-Reactive Protein
- Prostate-Specific Antigen
- Leuprolide
|
Topics |
- Adiponectin
(blood)
- Aged
- Antineoplastic Agents, Hormonal
(adverse effects, therapeutic use)
- Blood Pressure
- Body Composition
- Body Mass Index
- C-Reactive Protein
(metabolism)
- Gonadotropin-Releasing Hormone
(agonists)
- Humans
- Insulin Resistance
- Leuprolide
(adverse effects, therapeutic use)
- Lipids
(analysis)
- Male
- Metabolic Syndrome
(chemically induced)
- Prospective Studies
- Prostate-Specific Antigen
(blood)
- Prostatic Neoplasms
(drug therapy, metabolism)
- Syndrome
|