Abstract | BACKGROUND: METHODS: RESULTS: Patients with S-CAD had markedly elevated levels of specific MMPs (MMP-2, MMP-9), MMPIs ( alpha2-macroglobulin, tissue inhibitor of MMP 1), IMs ( C-reactive protein; interleukin [IL] 8; IL-10, regulated upon activation, normal T-cell expressed and secreted [ RANTES], endothelin, plasminogen activator inhibitor 1, and apolipoprotein C-III compared with patients with A-CAD (P < .005 for all measurements), whereas patients with A-CAD had significantly greater levels of MMP-3 and IL-1alpha compared with patients with S-CAD (P < or = .02 for both measurements). CONCLUSIONS:
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Authors | Paul A Gurbel, Rolf P Kreutz, Kevin P Bliden, Joseph DiChiara, Udaya S Tantry |
Journal | American heart journal
(Am Heart J)
Vol. 155
Issue 1
Pg. 56-61
(Jan 2008)
ISSN: 1097-6744 [Electronic] United States |
PMID | 18082490
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Inflammation Mediators
- Metalloproteases
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Topics |
- Aged
- Angioplasty, Balloon, Coronary
(methods, mortality)
- Arteriosclerosis
(diagnosis, mortality, therapy)
- Biomarkers
(analysis)
- Case-Control Studies
- Chronic Disease
- Coronary Artery Disease
(diagnosis, mortality, therapy)
- Disease Progression
- Female
- Fluoroimmunoassay
- Humans
- Inflammation Mediators
(analysis)
- Male
- Metalloproteases
(analysis)
- Middle Aged
- Probability
- Prognosis
- Risk Assessment
- Sensitivity and Specificity
- Severity of Illness Index
- Survival Analysis
- Treatment Outcome
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