Abstract | BACKGROUND: The present study was designed to investigate the role of the local renin-angiotensin-aldosterone system (RAAS), endothelin (ET) and the natriuretic peptide system (NPS) for the development of renal fibrosis and progressive renal disease in experimental unilateral ureteral obstructed (UUO) rats. METHODS: Male Sprague-Dawley rats (180-200 g) were unilaterally obstructed by ligation of the proximal ureters for 14 days. Control rats were treated in the same way, except that no ligature was made. The mRNA expressions of local renin-angiotensin system, aldosterone synthase ( CYP11B2), ET-1 and NPS was determined in the cortex by real-time polymerase chain reaction. RESULTS: CONCLUSION: The local RAAS and ET-1 was upregulated which may play a role in the progressive renal fibrosis in obstructed kidneys in rats with UUO. The enhanced activity of NPS in UUO kidney may play a role to compensate against progressive renal fibrosis in chronic obstructive uropathy.
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Authors | Eun Hui Bae, In Jin Kim, Jeong Woo Park, Seong Kwon Ma, Ki Chul Choi, Jong Un Lee, Soo Wan Kim |
Journal | Urologia internationalis
(Urol Int)
Vol. 79
Issue 2
Pg. 170-6
( 2007)
ISSN: 1423-0399 [Electronic] Switzerland |
PMID | 17851289
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | 2007 S. Karger AG, Basel |
Chemical References |
- Endothelins
- Natriuretic Peptides
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Topics |
- Animals
- Chronic Disease
- Disease Models, Animal
- Disease Progression
- Endothelins
(physiology)
- Fibrosis
- Kidney
(pathology)
- Male
- Natriuretic Peptides
(physiology)
- Rats
- Rats, Sprague-Dawley
- Renin-Angiotensin System
(physiology)
- Ureteral Obstruction
(physiopathology)
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