Increased splenic fluorodeoxyglucose uptake in a patient with granulomatous angitis.

Abstract

Although utility of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) has been rehearsed in large vessel vasculitides, it is not known if small vessel vasculitides are also associated with increased FDG uptake. Hereby described is a 64-year-old female patient with prolonged fever and splenomegaly, which was depicted as a hot area in FDG-PET. Splenectomy disclosed microaneurysms, giant cell granuloma, perivascular leukocytic infiltration with fibrinoid necrosis, consistent with granulomatous angitis. Serum myeloperoxidase-antineutrophil cytoplasmic antibody was positive. The present case illustrates that vasculitides affecting small vessels present increased FDG uptake as do those affecting large vessels.

• Authors: Hiroshi Maruoka, Takeharu Koga, Masaaki Takeo, Seiyo Honda, Kentaro Yuge, Takaaki Fukuda, Hisamichi Aizawa
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 46 Issue 12 Pg. 909-11 ( 2007) ISSN: 1349-7235 [Electronic] Japan
• PMID: 17575388 (Publication Type: Case Reports, Journal Article)

Chemical References

• Radiopharmaceuticals
• Fluorodeoxyglucose F18

Topics

• Female
• Fluorodeoxyglucose F18 (pharmacokinetics)
• Humans
• Middle Aged
• Positron-Emission Tomography (instrumentation)
• Radiography
• Radiopharmaceuticals (pharmacokinetics)
• Spleen (metabolism)
• Splenomegaly (diagnostic imaging, etiology, pathology)
• Treatment Outcome
• Vasculitis, Central Nervous System (complications, metabolism, pathology, therapy)