Microaneurysm

Aneurysm of the MICROVASCULATURE. Charcot–Bouchard aneurysms are aneurysms of the brain vasculature which is a common cause of CEREBRAL HEMORRHAGE. Retinal microaneurysm is an early diagnostic sign of DIABETIC RETINOPATHY.

Also Known As:

Charcot-Bouchard Aneurysm; Charcot-Bouchard Aneurysms; Miliary Aneurysm; Retinal Microaneurysm; Aneurysm, Charcot-Bouchard; Aneurysm, Miliary; Aneurysms, Charcot-Bouchard; Aneurysms, Miliary; Charcot Bouchard Aneurysm; Charcot Bouchard Aneurysms; Microaneurysm, Retinal; Microaneurysms; Microaneurysms, Retinal; Miliary Aneurysms; Retinal Microaneurysms

Networked: 680 relevant articles (19 outcomes, 52 trials/studies)

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 91362
- Vascular Diseases: 15138
  - Aneurysm: 24506
    - Microaneurysm: 680

Related Diseases

1.	Macular Edema
2.	Diabetic Retinopathy (Retinopathy, Diabetic)
3.	Hemorrhage
4.	Retinal Hemorrhage
5.	Cerebrovascular Disorders (Cerebrovascular Occlusion)

Experts

1.	Klein, Ronald: 12 articles (07/2010 - 07/2002)
2.	Wong, Tien Yin: 10 articles (01/2020 - 07/2002)
3.	Cunha-Vaz, José: 9 articles (02/2022 - 01/2007)
4.	Bandello, Francesco: 9 articles (01/2021 - 01/2012)
5.	Klein, Barbara E K: 9 articles (01/2021 - 07/2002)
6.	Querques, Giuseppe: 9 articles (01/2021 - 01/2012)
7.	Wong, Tien Y: 7 articles (01/2021 - 05/2004)
8.	Ogura, Yuichiro: 7 articles (05/2019 - 03/2014)
9.	Silva, Paolo S: 6 articles (05/2021 - 11/2014)
10.	Aiello, Lloyd Paul: 6 articles (12/2020 - 04/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Microaneurysm:

1.	Retinaldehyde (Retinal)IBA 03/01/2020 - "Upon OCTA, 118 (40.4%) eyes of the study group (n = 292 eyes) showed microvascular abnormalities including foveal avascular zone erosion (95 (32.5%) eyes), non-perfusion areas in the superficial and deep retinal layers (39 (13.4%) eyes and 19 (6.5%) eyes, respectively), and microaneurysms in the superficial and deep retinal layers (22 (7.5%) eyes and 31 (10.6%) eyes, resp.). " 01/01/2020 - "The present study assesses the consistency/repeatability of an automated assessment platform for the characterisation of retinal vascular features, quantification of microaneurysms (MA) and leakage foci in UWFA images. " 07/01/2015 - "Findings from this study indicate that hyperhexosemia can trigger retinal vascular changes similar to those seen in human DR including ME and microaneurysms. " 01/01/1986 - "By the end of the study, 109 out of 231 patients (47%) had developed retinal changes, half of which were classified as minimal (less than 5 microaneurysms). " 05/15/2023 - "Results indicated that OCTA was useful for the evaluation of qualitative and morphological retinal microcirculation and that intravitreal TA may decrease microaneurysms."
2.	Fluorescein (Funduscein)FDA LinkGeneric 11/01/2022 - "Morphology and fluorescein leakage in diabetic retinal microaneurysms: a study using multiple en face OCT angiography image averaging." 08/01/1996 - "This study describes an image-processing strategy which detects and quantifies microaneurysms present in digitized fluorescein angiograms. " 04/01/1989 - "The assessment of retinopathy was based on change in the number of microaneurysms (MAs) present in the macular field, as seen on fluorescein angiograms, over 3 yr. Forty-one patients did not complete the study. " 05/01/1983 - "This study describes a method for quantifying microaneurysms (MA) from fluorescein angiograms. " 11/01/2023 - "In fluorescein angiography, multiple hyperfluorescent lesions with leakage corresponding to microaneurysms were observed in the temporal and lower midperipheral areas; however, nonperfused areas were apparently absent. "
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/01/2020 - "There was a significant reduction in the FAZ in the SCP and DCP between visits 0 and 1. All anti-VEGF medications reduced the number of microaneurysms (p<0.01). " 01/01/2022 - "Presence of microaneurysms (MAs) is a predictor of the development and progression of DME, but its relationship with the treatment response to the anti-VEGF agents is not well known. " 11/01/2016 - "Although there was no significant difference in the SCP between anti-VEGF responders and poor responders, poor responders tended to show greater damage and more microaneurysms in the DCP (P < 0.001) and a larger FAZ area (P < 0.001). " 09/09/2023 - "Down-trending leakage indices and microaneurysm counts were demonstrated over 1 year of anti-VEGF therapy. " 01/01/2022 - "Evaluation of microaneurysms as predictors of therapeutic response to anti-VEGF therapy in patients with DME."
4.	Aldehyde Reductase (Aldose Reductase)IBA 12/01/1997 - "These studies indicate that aldose reductase inhibitors provide dose-dependent protection against pericyte degeneration and subsequent microaneurysms formation." 01/01/1993 - "These data support the dose-dependent effects of aldose reductase inhibitors in preventing pericyte degeneration and subsequent formation of microaneurysms (Archives Ophthalmol. " 10/01/1993 - "Biochemical factors such as nonenzymatic glycosylation and induction of the aldose reductase pathway seem to be of importance for the genesis of nonproliferative diabetic retinopathy, characterized by pericyte loss, basal membrane thickening and formation of microaneurysms. " 11/01/1989 - "Previous evidence from animal models indicated that aldose reductase inhibitors could prevent these capillary wall lesions, but only recently have aldose reductase inhibitors been tested for prevention of the subsequent retinal complications of diabetes, such as microaneurysms. " 09/01/1994 - "In prevention studies utilizing 0.5, 5.0, 10, and 16 mg/kg/day of the aldose reductase inhibitor M79175 (2-methyl-6-fluoro-spirochroman-4-5'-imidazolidine-2',4'-dione), pericyte ghost formation, and the subsequent appearance of microaneurysms, intraretinal hemorrhages, acellular capillaries associated with background retinopathy were arrested in a dose-dependent manner. "
5.	afliberceptIBA 11/01/2021 - "Eyes with proliferative diabetic retinopathy (PDR) have been shown to improve in the leakage index and microaneurysm (MA) count after intravitreal aflibercept (IAI) treatment. " 11/01/2021 - "The 2-Year Leakage Index and Quantitative Microaneurysm Results of the RECOVERY Study: Quantitative Ultra-Widefield Findings in Proliferative Diabetic Retinopathy Treated with Intravitreal Aflibercept." 12/01/2019 - "To evaluate the effects of intravitreal aflibercept (IVA) on the number of microaneurysms and sizes of nonperfused areas (NPAs) in eyes with diabetic macular edema (DME). " 12/01/2017 - "Three intravitreal injections of aflibercept were administered over 16 weeks following which there was resolution of leakage, release of vitreomacular traction, and resolution of microaneurysms. " 01/01/2022 - "However, the mean number of microaneurysms was marginally reduced (p = 0.06) in eyes treated with aflibercept at the end of the follow-up, and the incidence rates of supplementary panretinal photocoagulation (PRP) (p = 0.04) and subthreshold micropulse laser (SMPL) therapy sessions (p = 0.01) were also reduced. "
6.	Capsules (Microcapsules)IBA 12/19/2018 - "One study reported Sanqi Tongshu capsule might be associated with a greater reduction in microaneurysms and haemorrhages in the retina (very low-certainty evidence). " 01/01/2023 - "The Hexuemingmu Tablet (HXMMT) and Shuangdan Mingmu Capsule (SDMMC) combined with CD may be the most effective treatment for reducing microaneurysm volume and hemorrhage area (SUCRA, 94.48%, and 86.24%), respectively. "
7.	mesoglycanIBA 01/01/2012 - "Data emerging from our study show a direct action of Mesoglycan on endothelium retinal blood vessels and circulation, as we observed in patients we found a significant reduction in the number of microhemorrhages, microaneurysms and exudates. "
8.	Galactose (Galactopyranose)FDA LinkGeneric 11/01/1995 - "At 16 months, the galactose-fed untreated rats showed statistically significant increases over controls in both total mean capillary length and density, and two of the four rats examined had microaneurysms. " 06/01/2002 - "The galactose diet was removed from 15 dogs after 24 months, the time at which pericyte ghosts had previously been observed to develop, and from another 15 dogs after 31 months, when microaneurysms had previously been observed to develop. " 08/01/1996 - "In C57BL/6 mice fed 30% galactose for 21 to 26 months, saccular microaneurysms were observed in the retina, together with significant increases in the thickness of capillary basement membrane and the prevalence of acellular capillaries and pericyte ghosts. " 11/01/1995 - "At 24 months, all the galactose-fed untreated rats had microaneurysms and extensive areas with hypercellular meshworks composed of dilated channels characteristic of intraretinal microvascular abnormalities (IRMA). " 04/01/1995 - "The galactose diet was removed from 15 dogs after 24 months at which time pericyte ghosts in the retina had developed and another 15 dogs were removed from the galactose diet after 31 months when retinal microaneurysms had developed. "
9.	Endothelial Growth FactorsIBA 06/01/2011 - "For microaneurysms within the FAZ, 33 (54.1%) of respondents chose intravitreal antivascular endothelial growth factor agents as their first-line treatment. "
10.	TabletsIBA 01/01/2023 - "The Hexuemingmu Tablet (HXMMT) and Shuangdan Mingmu Capsule (SDMMC) combined with CD may be the most effective treatment for reducing microaneurysm volume and hemorrhage area (SUCRA, 94.48%, and 86.24%), respectively. "

Therapies and Procedures

1.	Light Coagulation 07/01/2008 - "Subsequent focal photocoagulation of the microaneurysms maintained the significant reduction of CMT for up to 6 months. " 04/01/2013 - "Focal photocoagulation may be a less invasive method for treating microaneurysms, and spectral domain optical coherence tomography is useful for evaluating the efficacy of photocoagulation." 01/01/2023 - "Photocoagulation was performed when the non-perfusion area (NPA) was ≥5 disc diameter (DD), and/or when ME relapsed due to microaneurysm. " 12/09/2022 - "Complete resolution of macula oedema was demonstrated following two rounds of ICGA-guided focal photocoagulation to the aforementioned microaneurysm cluster. " 01/01/2015 - "The 577-nm MP apparatus required less energy for SMLP than the 810-nm MP instrument and was suitable for direct photocoagulation of microaneurysms."
2.	Therapeutics 01/01/2022 - "At 24 months after therapy initiation, the logMAR BCVA improved from 0.58 ± 0.33 to 0.47 ± 0.38 (p < 0.01), the CRT decreased from 423.92 ± 135.84 to 316.36 ± 90.02 (p < 0.01), and the number of microaneurysms decreased from 142.14 ± 57.23 to 75.32 ± 43.86 (p < 0.01). " 11/11/2021 - "Standalone Flow Diversion Therapy Effectively Controls Rebleeding of Acutely Ruptured Internal Carotid Artery Trunk (Nonbranching) Microaneurysms." 01/01/2018 - "Microaneurysm formation was associated with delayed initial therapy. " 01/01/2016 - "Alternative therapy to suppress microaneurysms should be considered to prevent refractory ME in patients with BRVO." 03/01/2011 - "To report the largest cohort of ACoA microaneurysms treated with endovascular therapy over the course of the past 10 years. "
3.	Lasers (Laser) 01/01/2022 - "Accurate segmentation of microaneurysms (MAs) from adaptive optics scanning laser ophthalmoscopy (AOSLO) images is crucial for identifying MA morphologies and assessing the hemodynamics inside the MAs. " 01/01/2022 - "AOSLO-net: A Deep Learning-Based Method for Automatic Segmentation of Retinal Microaneurysms From Adaptive Optics Scanning Laser Ophthalmoscopy Images." 11/01/2018 - "Association of Microaneurysms on Adaptive Optics Scanning Laser Ophthalmoscopy With Surrounding Neuroretinal Pathology and Visual Function in Diabetes." 01/01/2018 - "Estimation of Diabetic Retinal Microaneurysm Perfusion Parameters Based on Computational Fluid Dynamics Modeling of Adaptive Optics Scanning Laser Ophthalmoscopy." 05/01/2016 - "Microaneurysms within the macular areas were treated by focal application of laser shots sufficient to bleach them. "
4.	Aftercare (After-Treatment) 01/01/2023 - "During the 24-month follow-up period, changes in best-corrected visual acuity (BCVA), central foveal thickness (CFT), retinal vein diameter, number of microaneurysms (MA), neovascularization (NV) area, hard exudate (HE) area, size of the foveal avascular zone (FAZ), superficial capillary plexus (SCP) blood flow density, and adverse effects were recorded and compared between the two groups at baseline and at 6, 12, 18, and 24 months after treatment. " 12/01/2019 - "A significant correlation was found between the CRT and number of microaneurysms at both baseline (r = 0.56; P = 0.004) and after treatment (r = 0.53; P = 0.006). " 03/01/2007 - "The number of micro-hemorrage, microaneurysm and the mean defect (MD) of visual field in treated group decreased obviously after treatment and had significant difference with that in control group (P < 0.05). " 06/01/2021 - "Within-group comparison: There were no significant differences in best-corrected visual acuity (BCVA), central foveal thickness (CFT), and microaneurysms in the laser group before and after treatment, but there were statistically significant improvements in the combination group. " 08/12/2019 - "Compared before treatment, the visual acuity, TCM symptom scores, fundus microaneurysm and hemorrhage points in 34 patients (68 eyes) were significantly improved after treatment (P<0.05). "
5.	Semiconductor Lasers 04/01/1995 - "Preliminary data suggest that diode laser therapy induces closure of leaking retinal microaneurysms and is effective in the treatment of diabetic macular oedema." 01/01/2015 - "The age, sex, HbA1c level, best-corrected visual acuity, central macular thickness, insulin use, pioglitazone use, systemic hypertension, serous retinal detachment, proteinuria, panretinal photocoagulation, microaneurysm photocoagulation (MAPC), subthreshold micropulse diode laser photocoagulation (SMDLP), cataract surgery, and history of vitrectomy were examined by logistic regression analysis. "