Abstract | BACKGROUND: METHODS: RESULTS: Concentrations were lower in CSF than serum or plasma for HCY (0.09 vs 9.4 micromol/L), SAH (13.2 vs 16.8 nmol/L), cystathionine (54 vs 329 nmol/L), and holotranscobalamin (16 vs 63 pmol/L), whereas concentrations in CSF were higher for MMA (359 vs 186 nmol/L) and SAM (270 vs 113 nmol/L; all P <0.05). CSF concentrations of HCY correlated significantly with CSF folate (r = -0.46), CSF SAH (r = 0.48), CSF- albumin (r = 0.31), and age (r = 0.32). Aging was also associated with lower concentrations of CSF- folate and higher CSF-SAH. The relationship between serum and CSF folate depended on serum folate: the correlation (r) of serum and CSF- folate was 0.69 at serum folate <15.7 nmol/L. CSF concentrations of MMA and holotranscobalamin were not significantly correlated. CONCLUSIONS:
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Authors | Rima Obeid, Panagiotis Kostopoulos, Jean-Pierre Knapp, Mariz Kasoha, George Becker, Klaus Fassbender, Wolfgang Herrmann |
Journal | Clinical chemistry
(Clin Chem)
Vol. 53
Issue 2
Pg. 326-33
(Feb 2007)
ISSN: 0009-9147 [Print] England |
PMID | 17200133
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Transcobalamins
- Homocysteine
- Cystathionine
- Methylmalonic Acid
- Folic Acid
- Vitamin B 12
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Topics |
- Adult
- Aged
- Aging
(metabolism)
- Biomarkers
(blood, cerebrospinal fluid)
- Cystathionine
(blood, cerebrospinal fluid)
- Female
- Folic Acid
(blood, cerebrospinal fluid)
- Homocysteine
(blood, cerebrospinal fluid)
- Humans
- Male
- Methylmalonic Acid
(blood, cerebrospinal fluid)
- Middle Aged
- Transcobalamins
(analysis, cerebrospinal fluid)
- Vitamin B 12
(blood, cerebrospinal fluid)
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