Abstract | BACKGROUND: METHODS: Three hundred and twenty-four patients with type 2 diabetes were divided into two groups based on presence (CAD group, n = 241) or absence (control group, n = 83) of angiographically-documented CAD (lumen diameter narrowing > or =70%). Serum levels of glycated albumin and hs-CRP as well as serum concentrations of glucose, lipids, creatinine, blood urea nitrogen and uric acid were measured in both groups. Predictors of CAD were determined using multivariate logistic regression model and receiver-operating characteristic (ROC) curves. RESULTS:
Serum glycated albumin and hs-CRP levels were significantly increased in diabetic patients with CAD. Multivariate regression analysis revealed that male gender, age, serum levels of glycated albumin, hs-CRP, creatinine and lipoprotein (a) were independent predictors for CAD. Areas under the curve of glycated albumin and hs-CRP and for regression model were 0.654 (95%CI 0.579-0.730, P < 0.001), 0.721 (95%CI 0.658-0.785, P < 0.001) and 0.824 (95% CI 0.768-0.879, P < 0.001), respectively. The optimal values of cut-off point were 18.7% (sensitivity 67.9%, specificity 60.0%) for glycated albumin and 5.2 mg/l (sensitivity 72.2%, specificity 60.0%) for hs-CRP to predict CAD. Logistic regression model was defined as: P/(1-P) = EXP(-1.5 + 1.265 gender + 0.812 age + 1.24 glycated albumin + 0.953 hs-CRP + 0.902 lipoprotein(a) + 1.918 creatinine). The optimal probability value for predicting CAD in type 2 diabetic patients was 0.648 (sensitivity 82.3%, specificity 68.6%). CONCLUSION:
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Authors | Li Jin Pu, Lin Lu, Xue Wei Xu, Rui Yan Zhang, Qi Zhang, Jian Sheng Zhang, Jian Hu, Zheng Kun Yang, Feng Hua Ding, Qiu Jin Chen, Sheng Lou, Jie Shen, Dan Hong Fang, Wei Feng Shen |
Journal | Cardiovascular diabetology
(Cardiovasc Diabetol)
Vol. 5
Pg. 27
(Dec 20 2006)
ISSN: 1475-2840 [Electronic] England |
PMID | 17178005
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Blood Glucose
- Glycation End Products, Advanced
- Serum Albumin
- C-Reactive Protein
- Glycated Serum Albumin
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Topics |
- Biomarkers
(blood)
- Blood Glucose
(analysis)
- C-Reactive Protein
(analysis)
- Coronary Angiography
- Coronary Disease
(blood, diagnosis, diagnostic imaging)
- Diabetes Mellitus, Type 2
(blood)
- Diabetic Angiopathies
(blood, diagnostic imaging)
- Glycation End Products, Advanced
- Humans
- Postprandial Period
- Predictive Value of Tests
- Regression Analysis
- Serum Albumin
(analysis)
- Glycated Serum Albumin
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