Abstract | RATIONALE: OBJECTIVES: METHODS: Lung function was assessed by a combination of whole-body barometric plethysmography, invasive measurement of airway resistance, and isometric force measurements in isolated bronchial rings. M2 muscarinic receptor expression was assessed by Western blotting, and function was assessed by electrical field stimulation of tracheas in the presence/absence of gallamine. Allergic airway disease was examined after ovalbumin sensitization and exposure. MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS:
|
Authors | Michelle A Carey, Jeffrey W Card, J Alyce Bradbury, Michael P Moorman, Najwa Haykal-Coates, Stephen H Gavett, Joan P Graves, Vickie R Walker, Gordon P Flake, James W Voltz, Daling Zhu, Elizabeth R Jacobs, Azzeddine Dakhama, Gary L Larsen, Joan E Loader, Erwin W Gelfand, Dori R Germolec, Kenneth S Korach, Darryl C Zeldin |
Journal | American journal of respiratory and critical care medicine
(Am J Respir Crit Care Med)
Vol. 175
Issue 2
Pg. 126-35
(Jan 15 2007)
ISSN: 1073-449X [Print] United States |
PMID | 17095746
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Allergens
- Cytokines
- Estrogen Receptor alpha
- Estrogens
- Receptor, Muscarinic M2
- Methacholine Chloride
- Serotonin
- Ovalbumin
- Acetylcholine
|
Topics |
- Acetylcholine
(metabolism)
- Allergens
(immunology)
- Animals
- Bronchial Hyperreactivity
(blood, etiology, physiopathology)
- Cytokines
(metabolism)
- Electrophysiology
- Estrogen Receptor alpha
(genetics, physiology)
- Estrogens
(blood)
- Female
- Inflammation
(immunology)
- Lung
(drug effects, innervation, physiopathology)
- Methacholine Chloride
(pharmacology)
- Mice
- Mice, Knockout
- Ovalbumin
(immunology)
- Peripheral Nerves
(physiology)
- Plethysmography
- Receptor, Muscarinic M2
(analysis, metabolism)
- Respiratory Hypersensitivity
(etiology, immunology, physiopathology)
- Serotonin
(pharmacology)
- Trachea
(drug effects, innervation, physiopathology)
|