Abstract | BACKGROUND: This study analyzes the impact of Staphylococcus aureus enterotoxins (SAEs) and the inflammatory pattern in polyps from China. METHODS: RESULTS: The number of EG2+ eosinophils was significantly lower in polyps from Chinese patients versus white patients. Chinese polyps showed significantly increased IgE and soluble interleukin-2 receptor versus control samples, whereas TGF-beta1 was significantly decreased. Ten of 27 samples in the polyp group versus 0 of 15 controls contained SAE- IgE (p < 0.01). TGF-beta1 was significantly down-regulated in SAE+ samples versus SAE- samples (p = 0.04). CONCLUSION:
Nasal polyps from China are characterized by B- and T-cell activation, a minor eosinophilic inflammation compared with polyps from white subjects, and a decrease in TGF-beta1 in comparison with control inferior turbinate tissue. One-third of patients with polyps showed an IgE response to SAEs.
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Authors | Nan Zhang, Gabriele Holtappels, Cindy Claeys, Ganquan Huang, Paul van Cauwenberge, Claus Bachert |
Journal | American journal of rhinology
(Am J Rhinol)
2006 Jul-Aug
Vol. 20
Issue 4
Pg. 445-50
ISSN: 1050-6586 [Print] United States |
PMID | 16955777
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Enterotoxins
- Eosinophil Granule Proteins
- Transforming Growth Factor beta1
- Immunoglobulin E
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Topics |
- Adolescent
- Adult
- Aged
- Asian People
- B-Lymphocytes
(immunology)
- China
- Cytokines
(analysis)
- Enterotoxins
(immunology)
- Eosinophil Granule Proteins
(analysis)
- Eosinophils
(chemistry, immunology)
- Female
- Humans
- Immunoglobulin E
(analysis)
- Lymphocyte Activation
- Male
- Middle Aged
- Nasal Polyps
(chemistry, immunology, microbiology)
- Rhinitis
(immunology, microbiology)
- Staphylococcus aureus
(immunology)
- T-Lymphocytes
(immunology)
- Transforming Growth Factor beta1
(analysis)
- White People
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