Abstract | OBJECTIVE: METHOD: Subjects meeting criteria for the Structured Clinical Interview for DSM-III-R Personality Disorders for borderline personality disorder (43 women and 9 men) were randomly assigned in a 1:1 ratio to 15 mg/day of aripiprazole (N=26) or placebo (N=26) for 8 weeks. Primary outcome measures were changes in scores on the symptom checklist (SCL-90-R), the Hamilton Depression Rating Scale (HAM-D), the Hamilton Anxiety Rating Scale (HAM-A), and the State-Trait Anger Expression Inventory and were assessed weekly. Side effects and self-injury were assessed with a nonvalidated questionnaire. RESULTS: According to the intent-to-treat principle, significant changes in scores on most scales of the SCL-90-R, the HAM-D, the HAM-A, and all scales of the State-Trait Anger Expression Inventory were observed in the subjects treated with aripiprazole after 8 weeks. Self-injury occurred in the groups. The reported side effects were headache, insomnia, nausea, numbness, constipation, and anxiety. CONCLUSIONS:
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Authors | Marius K Nickel, Moritz Muehlbacher, Cerstin Nickel, Christian Kettler, Francisco Pedrosa Gil, Egon Bachler, Wiebke Buschmann, Nadine Rother, Reinhold Fartacek, Christoph Egger, Javaid Anvar, Wolfhardt K Rother, Thomas H Loew, Patrick Kaplan |
Journal | The American journal of psychiatry
(Am J Psychiatry)
Vol. 163
Issue 5
Pg. 833-8
(May 2006)
ISSN: 0002-953X [Print] United States |
PMID | 16648324
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antipsychotic Agents
- Piperazines
- Placebos
- Quinolones
- Aripiprazole
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Topics |
- Aggression
(drug effects)
- Anger
(drug effects)
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Aripiprazole
- Borderline Personality Disorder
(diagnosis, drug therapy, psychology)
- Double-Blind Method
- Female
- Humans
- Male
- Personality Inventory
- Piperazines
(adverse effects, therapeutic use)
- Placebos
- Psychiatric Status Rating Scales
- Quinolones
(adverse effects, therapeutic use)
- Severity of Illness Index
- Suicide
(psychology)
- Surveys and Questionnaires
- Treatment Outcome
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