Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels.
Abstract | OBJECTIVE: To investigate whether intraarticular (IA) glucocorticoid (GC) therapy diminishes synovial cell infiltration, vascularity, expression of proinflammatory cytokines, and adhesion molecule levels in patients with chronic arthritides. METHODS: RESULTS: IA GC treatment resulted in good clinical response in 29 of 31 joints. After therapeutic intervention, the number of synovial T lymphocytes declined, whereas the number of macrophages remained unchanged. Overall synovial protein expression of TNF, IL-1beta, extranuclear HMGB-1, VEGF, and ICAM-1 was reduced at followup tissue sampling, while no significant effects were observed regarding vascularity. In contrast, expression of IL-1alpha, VEGF, and cytoplasmic HMGB-1 protein in vascular endothelial cells was not affected. GC therapy down-regulated levels of messenger RNA encoding IL-1alpha and IL-1beta, but not TNF or HMGB-1. CONCLUSION: Synovial cell infiltration and proinflammatory cytokine expression were affected in a multifaceted manner by IA GC treatment. Marked reduction of synovial T lymphocytes, TNF, IL-1beta, extranuclear HMGB-1, ICAM-1, and VEGF occurred in association with beneficial clinical effects. Unexpectedly, macrophage infiltration and proinflammatory endothelial cytokine expression remained unchanged. These findings may reflect mechanisms controlling the transiency of clinical improvement frequently observed after IA GC injection.
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Authors | Erik af Klint, Cecilia Grundtman, Marianne Engström, Anca Irinel Catrina, Dimitrios Makrygiannakis, Lars Klareskog, Ulf Andersson, Ann-Kristin Ulfgren |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 52
Issue 12
Pg. 3880-9
(Dec 2005)
ISSN: 0004-3591 [Print] United States |
PMID | 16320336
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Cytokines
- Glucocorticoids
- HMGB1 Protein
- RNA, Messenger
- Triamcinolone Acetonide
- triamcinolone hexacetonide
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents
(administration & dosage)
- Arthritis, Rheumatoid
(drug therapy, immunology, pathology)
- Biopsy
- Blood Vessels
(drug effects, immunology)
- Cytokines
(genetics)
- Female
- Gene Expression
(immunology)
- Glucocorticoids
(administration & dosage)
- HMGB1 Protein
(genetics, metabolism)
- Humans
- Injections, Intra-Articular
- Macrophages
(pathology)
- Male
- Middle Aged
- RNA, Messenger
(analysis)
- Signal Transduction
(drug effects, immunology)
- Synovial Membrane
(blood supply, drug effects, immunology)
- Synovitis
(drug therapy, immunology, pathology)
- T-Lymphocytes
(pathology)
- Triamcinolone Acetonide
(administration & dosage, analogs & derivatives)
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