Abstract | OBJECTIVE: PATIENTS AND METHODS: A controlled, clinical, randomized, double blind and crossover study was made in 36 patients with allergic rhinitis and asthma following one of the next treatment regimes: group a) nasal budesonide plus oral zafirlukast twice a day or group b) nasal budesonide plus oral loratadine/ pseudoephedrine twice a day, both of them during six weeks, and two weeks of washing and crossover of the treatments during six more weeks. Changes in the rhinitis and asthma symptoms, blood eosinophils, pulmonary function testing, and nasal cytology were evaluated before and after the treatment. RESULTS: 19 patients were assigned to group a, whereas 17 patients to group b. The age ranged between 16 to 45 years, and it predominated the female group, 70 and 89%, respectively (statistically no significant). During the first six weeks of the treatment, V0 to V3, both groups of patients got better nasal symptoms but group a was superior to group b. However, in bronchial symptoms, cough, wheezing and breathlessness, group a showed efficacy in comparison with group b, where no significant improvement was shown. Once the crossover was made, from V5 to V7, there was no difference between both groups. The other evaluated indicators, such as eosinophilia, VEF1 and nasal eosinophils, had a significant improvement before and at the end of the study. CONCLUSIONS:
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Authors | Hector Hugo Salas Benitez, Victor Manuel Almeida Arvizu, Daniel Jijón Gutiérrez, Guillermo Arturo Guidos Fogelbach, Antonio Castellanos Olivares, Francisco Vázquez Nava, Héctor Chong Velázquez, Maria del Carmen González Pérez, Alejandra Mora Nieto, Eduardo Castro Rodríguez |
Journal | Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
(Rev Alerg Mex)
2005 Mar-Apr
Vol. 52
Issue 2
Pg. 90-5
ISSN: 0002-5151 [Print] Mexico |
Vernacular Title | Budesonida nasal más zafirlukast vs budesonida nasal más loratadina- pseudoefedrina en el control de los síntomas de la rinitis y el asma. |
PMID | 16158782
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenergic Agents
- Anti-Allergic Agents
- Anti-Asthmatic Agents
- Histamine H1 Antagonists, Non-Sedating
- Indoles
- Leukotriene Antagonists
- Phenylcarbamates
- Sulfonamides
- Tosyl Compounds
- Budesonide
- Loratadine
- Ephedrine
- zafirlukast
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Topics |
- Administration, Intranasal
- Administration, Oral
- Adolescent
- Adrenergic Agents
(administration & dosage, therapeutic use)
- Adult
- Anti-Allergic Agents
(administration & dosage, therapeutic use)
- Anti-Asthmatic Agents
(administration & dosage, therapeutic use)
- Asthma
(drug therapy)
- Budesonide
(administration & dosage, therapeutic use)
- Cross-Over Studies
- Double-Blind Method
- Drug Therapy, Combination
- Ephedrine
(administration & dosage, therapeutic use)
- Female
- Histamine H1 Antagonists, Non-Sedating
(administration & dosage, therapeutic use)
- Humans
- Indoles
- Leukotriene Antagonists
(administration & dosage, therapeutic use)
- Loratadine
(administration & dosage, therapeutic use)
- Male
- Middle Aged
- Phenylcarbamates
- Respiratory Hypersensitivity
(drug therapy)
- Rhinitis, Allergic, Perennial
(drug therapy)
- Rhinitis, Allergic, Seasonal
(drug therapy)
- Sulfonamides
- Tosyl Compounds
(administration & dosage, therapeutic use)
- Treatment Outcome
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