Abstract | AIM: METHODS: This study is a randomized, double-blind, placebo-controlled parallel comparison study of sibutramine 15 mg/day and placebo. Forty-eight eligible obese patients with Type 2 diabetes (age between 30 and 75 years with body mass index > or = 27 kg/m(2)) were randomly assigned to receive either placebo (n = 24) or sibutramine (15 mg/day) (n = 24) for 6 months. Fifteen subjects in each group underwent meal tests and modified insulin suppression tests before and after 6 months' treatment. RESULTS: After 6 months of sibutramine treatment statistically significant changes from baseline were observed for body weight (85.4 +/- 2.5 vs. 82.9 +/- 2.4 kg, P < 0.005) and body mass index (32.0 +/- 0.7 vs. 31.4 +/- 0.6 kg/m(2), P < 0.05) without a significant alteration of waist-hip ratio (W/H), blood pressure, heart rate, glycaemic parameters or lipid profiles. The steady-state plasma glucose (SSPG) level during the modified insulin suppression test was significantly reduced in the sibutramine group (17.33 +/- 2.92 vs. 14.29 +/- 4.19 mmol/l, P < 0.05) despite similar steady-state plasma insulin (SSPI) concentrations. In addition, serum adiponectin and C-reactive protein (CRP) levels remained unchanged, although modest weight reduction was achieved after sibutramine treatment. There were also no significant correlations between changes in serum adiponectin and reduction of SSPG or body weight. Daily ambient plasma insulin and glucose concentrations in response to a test meal were not significantly different in subjects receiving sibutramine treatment. CONCLUSIONS:
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Authors | Y-J Hung, Y-C Chen, D Pei, S-W Kuo, C-H Hsieh, L-Y Wu, C-T He, C H Lee, S C Fan, W H-H Sheu |
Journal | Diabetic medicine : a journal of the British Diabetic Association
(Diabet Med)
Vol. 22
Issue 8
Pg. 1024-30
(Aug 2005)
ISSN: 0742-3071 [Print] England |
PMID | 16026368
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adiponectin
- Anti-Obesity Agents
- Appetite Depressants
- Blood Glucose
- Cyclobutanes
- Insulin
- Intercellular Signaling Peptides and Proteins
- sibutramine
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Topics |
- Adiponectin
- Adult
- Aged
- Anti-Obesity Agents
(therapeutic use)
- Appetite Depressants
(therapeutic use)
- Blood Glucose
(analysis)
- Body Weight
(drug effects)
- Cyclobutanes
(therapeutic use)
- Diabetes Mellitus, Type 2
(drug therapy)
- Double-Blind Method
- Female
- Humans
- Insulin
(blood)
- Intercellular Signaling Peptides and Proteins
(blood)
- Male
- Middle Aged
- Obesity
(complications, drug therapy)
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