Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue.

Abstract	Adiponectin is a hormone secreted from adipose tissue, and serum levels are decreased with obesity and insulin resistance. Because prolactin (PRL) and growth hormone (GH) can affect insulin sensitivity, we investigated the effects of these hormones on the regulation of adiponectin in human adipose tissue in vitro and in rodents in vivo. Adiponectin secretion was significantly suppressed by PRL and GH in in vitro cultured human adipose tissue. Furthermore, PRL increased adiponectin receptor 1 (AdipoR1) mRNA expression and GH decreased AdipoR2 expression in the cultured human adipose tissue. In transgenic mice expressing GH, and female mice expressing PRL, serum levels of adiponectin were decreased. In contrast, GH receptor deficient mice had elevated adiponectin levels, while PRL receptor deficient mice were unaffected. In conclusion, we demonstrate gene expression of AdipoR1 and AdipoR2 in human adipose tissue for the first time, and show that these are differentially regulated by PRL and GH. Both PRL and GH reduced adiponectin secretion in human adipose tissue in vitro and in mice in vivo. Decreased serum adiponectin levels have been associated with insulin resistance, and our data in human tissue and in transgenic mice suggest a role for adiponectin in PRL and GH induced insulin resistance.
Authors	Louise Nilsson, Nadine Binart, Mohammad Bohlooly-Y, Margareta Bramnert, Emil Egecioglu, Jon Kindblom, Paul A Kelly, John J Kopchick, Christopher J Ormandy, Charlotte Ling, Håkan Billig
Journal	Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 331 Issue 4 Pg. 1120-6 (Jun 17 2005) ISSN: 0006-291X [Print] United States
PMID	15882993 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	ADIPOR1 protein, human ADIPOR2 protein, human Receptors, Adiponectin Receptors, Cell Surface Receptors, Prolactin Prolactin Growth Hormone
Topics	Adult Animals Female Growth Hormone (physiology) Humans Mice Mice, Inbred C57BL Mice, Inbred CBA Middle Aged Prolactin (physiology) Receptors, Adiponectin Receptors, Cell Surface (genetics, metabolism) Receptors, Prolactin (genetics, metabolism)

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