Lansoprazole ameliorates intestinal mucosal damage induced by ischemia-reperfusion in rats.

Abstract

AIM:

To investigate the protective effect of lansoprazole on ischemia and reperfusion (I/R)-induced rat intestinal mucosal injury in vivo.

METHODS:

Intestinal damage was induced by clamping both the superior mesenteric artery and the celiac trunk for 30 min followed by reperfusion in male Sprague-Dawley rats. Lansoprazole was given to rats intraperitoneally 1 h before vascular clamping.

RESULTS:

Both the intraluminal hemoglobin and protein levels, as indices of mucosal damage, significantly increased in I/R-groups comparison with those of sham-operation groups. These increases in intraluminal hemoglobin and protein levels were significantly inhibited by the treatment with lansoprazole at a dose of 1 mg/kg. Small intestine exposed to I/R resulted in mucosal inflammation that was characterized by significant increases in thiobarbituric acid-reactive substances (TBARS), tissue-associated myeloperoxidase activity (MPO), and mucosal content of rat cytokine-induced neutrophil chemoattractant-1 (CINC-1). These increases in TBARS, MPO activities and CINC-1 content in the intestinal mucosa after I/R were all inhibited by pretreatment with lansoprazole at a dose of 1 mg/kg. Furthermore, the CINC-1 mRNA expression was increased during intestinal I/R, and this increase in mRNA expression was inhibited by treatment with lansoprazole.

CONCLUSION:

Lansoprazole inhibits lipid peroxidation and reduces development of intestinal mucosal inflammation induced by I/R in rats, suggesting that lansoprazole may have a therapeutic potential for I/R injury.

• Authors: Hiroshi Ichikawa, Norimasa Yoshida, Tomohisa Takagi, Naoya Tomatsuri, Kazuhiro Katada, Yutaka Isozaki, Kazuhiko Uchiyama, Yuji Naito, Takeshi Okanoue, Toshikazu Yoshikawa
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 10 Issue 19 Pg. 2814-7 (Oct 01 2004) ISSN: 1007-9327 [Print] United States
• PMID: 15334676 (Publication Type: Journal Article)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Gastrointestinal Agents
• Lansoprazole
• Omeprazole

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Animals
• Gastrointestinal Agents (therapeutic use)
• Inflammation (prevention & control)
• Intestinal Mucosa (blood supply, drug effects, pathology)
• Ischemia (prevention & control)
• Lansoprazole
• Lipid Peroxidation (drug effects)
• Male
• Omeprazole (analogs & derivatives, therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Reperfusion