Abstract | OBJECTIVES: METHODS: RESULTS: MCP-1 was expressed in cancer cells of 31 SCC (55.4%) and in stromal cells mainly identified as macrophages of 16 SCC (28.6%). CCR-2 was expressed in stromal cells of all SCC and in vascular endothelial cells of 15 SCC (26.8%). There was a significant correlation between the expression of MCP-1 in cancer cells and of CCR-2 in stromal cells. TP was expressed in stromal cells in 76.7% of the SCC. Monocytic count, MVD, and Ki-67 LI in SCC with MCP-1 expression in cancer cells were higher than that without, and apoptotic index in SCC with MCP-1 expression in cancer cells were lower than that without. Furthermore, the monocytic count was positively correlated with MVD, while it was inversely correlated with apoptotic index. Clinicopathologically, MCP-1 expression in cancer cells was correlated with venous invasion, distant metastasis, and lymph node metastasis. Monocytic count in SCC with venous invasion, distant metastasis, or lymph node metastasis was higher than that without them. Five-year survival rate in the patients with high monocytic count or MCP-1 expression was worse than that with a low monocytic count or without MCP-1 expression. CONCLUSIONS: These results suggest that MCP-1 expression and macrophage infiltration is associated with angiogenic promotion in esophageal SCC. MCP-1 expression may be interactively associated with macrophage infiltration in esophageal SCC; MCP-1 may play an important role in tumor angiogenesis through production of angiogenic factors, such as TP, by recruited macrophages in esophageal SCC. Furthermore, CCR-2 expression in vascular endothelial cells may participate partially in angiogenesis. Clinicopathologically, esophageal SCC patients with MCP-1 expression have no favorable prognosis.
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Authors | Naohiko Koide, Akihito Nishio, Toshiyuki Sato, Atsushi Sugiyama, Shin-ichi Miyagawa |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 99
Issue 9
Pg. 1667-74
(Sep 2004)
ISSN: 0002-9270 [Print] United States |
PMID | 15330899
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Angiogenesis Inducing Agents
- Biomarkers, Tumor
- Chemokine CCL2
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Topics |
- Angiogenesis Inducing Agents
(metabolism)
- Biomarkers, Tumor
(metabolism)
- Biopsy, Needle
- Carcinoma, Squamous Cell
(metabolism, mortality, pathology, surgery)
- Cell Movement
- Chemokine CCL2
(metabolism)
- Cohort Studies
- Culture Techniques
- Esophageal Neoplasms
(metabolism, mortality, pathology, surgery)
- Female
- Humans
- Immunohistochemistry
- In Situ Nick-End Labeling
- Japan
(epidemiology)
- Macrophages
(physiology)
- Male
- Neoplasm Staging
- Predictive Value of Tests
- Probability
- Prognosis
- Proportional Hazards Models
- Retrospective Studies
- Risk Assessment
- Statistics, Nonparametric
- Survival Analysis
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