Abstract | OBJECTIVE: To investigate the clinical potential of several markers of spinal cord ischemia in cerebrospinal fluid (CSF) and serum during aneurysm repair of the descending thoracic or thoracoabdominal aorta. DESIGN: Observational study of consecutive patients. Nonblinded, nonrandomized. SETTING: University hospital thoracic surgical unit. PARTICIPANTS: Eleven consecutive elective patients. INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: CSF and serum levels of S100B (and its isoforms S100A1B and S100BB), neuronal-specific enolase (NSE), and the CSF levels of glial fibrillary acidic protein (GFAp) and lactate were determined. Two patients had postoperative neurologic deficit. One with a stroke showed a 540-fold increased GFAp, a 6-fold NSE, and S100B increase in CSF. One with paraplegia had a 270-fold increase in GFAp, a 2-fold increase in NSE, and 5-fold increased S100B in CSF. One patient without deficit increased GFAp 10-fold, NSE 4-fold, and S100B 23-fold in CSF. CSF lactate increased >50% in 6 of 9 patients without neurologic deficit. Serum S100B increased within 1 hour of surgery in all patients without any concomitant increase in CSF. S100A1B was about 70% of total S100B in both serum and CSF in patients with or without neurologic defects. S100B in CSF increased 3-fold in 3 of 9 asymptomatic patients. CONCLUSIONS:
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Authors | Russell E Anderson, Anders Winnerkvist, Lars-Olof Hansson, Olle Nilsson, Lars Rosengren, Göran Settergren, Jarle Vaage |
Journal | Journal of cardiothoracic and vascular anesthesia
(J Cardiothorac Vasc Anesth)
Vol. 17
Issue 5
Pg. 598-603
(Oct 2003)
ISSN: 1053-0770 [Print] United States |
PMID | 14579213
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Glial Fibrillary Acidic Protein
- Nerve Growth Factors
- S100 Calcium Binding Protein beta Subunit
- S100 Proteins
- S100B protein, human
- Lactic Acid
- Phosphopyruvate Hydratase
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Aortic Aneurysm, Abdominal
(blood, cerebrospinal fluid, surgery)
- Aortic Aneurysm, Thoracic
(blood, cerebrospinal fluid, surgery)
- Biomarkers
(blood, cerebrospinal fluid)
- Cerebrospinal Fluid
(chemistry, metabolism)
- Elective Surgical Procedures
- Female
- Glial Fibrillary Acidic Protein
(blood, cerebrospinal fluid)
- Humans
- Lactic Acid
(blood, cerebrospinal fluid)
- Male
- Middle Aged
- Nerve Growth Factors
(blood, cerebrospinal fluid)
- Paraplegia
(blood, cerebrospinal fluid, etiology)
- Phosphopyruvate Hydratase
(blood, cerebrospinal fluid)
- Postoperative Complications
(blood, cerebrospinal fluid, etiology)
- Reoperation
- S100 Calcium Binding Protein beta Subunit
- S100 Proteins
(blood, cerebrospinal fluid)
- Severity of Illness Index
- Spinal Cord Ischemia
(blood, cerebrospinal fluid, etiology)
- Statistics as Topic
- Stroke
(blood, cerebrospinal fluid, surgery)
- Time Factors
- Treatment Outcome
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