Abstract | OBJECTIVES: DESIGN: METHODS: RESULTS:
Quercetin markedly inhibited the development of L-NAME-induced hypertension. This effect was accompanied by a partial or full prevention of most of the effects induced by L-NAME, such as: (1) increases in the left ventricular and kidney weight indices; (2) proteinuria; (3) renal histological lesions, including hyaline arteriopathy and thickening of the vascular wall with moderate decrease of the lumen; (4) increased endothelium-dependent contraction; (5) increased vascular thromboxane B2 (TXB2) synthesis; (6) reduced plasma concentrations of nitrites plus nitrates (NOx); (7) increased plasma and hepatic malondialdehyde (MDA) concentrations; and (8) reduced glutathione peroxidase activity. In most cases these effects were dose dependent, but none of them were observed in normotensive animals. CONCLUSIONS:
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Authors | Juan Duarte, Rosario Jiménez, Francisco O'Valle, Milagros Galisteo, Raquel Pérez-Palencia, Felix Vargas, Francisco Pérez-Vizcaíno, Antonio Zarzuelo, Juan Tamargo |
Journal | Journal of hypertension
(J Hypertens)
Vol. 20
Issue 9
Pg. 1843-54
(Sep 2002)
ISSN: 0263-6352 [Print] Netherlands |
PMID | 12195128
(Publication Type: Journal Article)
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Chemical References |
- Enzyme Inhibitors
- Nitric Oxide
- Malondialdehyde
- Quercetin
- Glutathione Peroxidase
- Prostaglandin-Endoperoxide Synthases
- NG-Nitroarginine Methyl Ester
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Topics |
- Animals
- Blood
(metabolism)
- Blood Pressure
- Dose-Response Relationship, Drug
- Enzyme Inhibitors
(pharmacology)
- Glutathione Peroxidase
(metabolism)
- Heart Ventricles
- Kidney
(pathology)
- Liver
(metabolism)
- Male
- Malondialdehyde
(metabolism)
- Myocardium
(pathology)
- NG-Nitroarginine Methyl Ester
(pharmacology)
- Nitric Oxide
(deficiency, metabolism)
- Organ Size
- Prostaglandin-Endoperoxide Synthases
(metabolism)
- Proteinuria
(urine)
- Quercetin
(administration & dosage, pharmacology)
- Rats
- Rats, Wistar
- Vasomotor System
(physiopathology)
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