Abstract |
Polymorphisms of the genes for angiotensin-converting enzyme (ACE) and angiotensinogen, the proteins of the renin-angiotensin system (RAS), were tested for association with the polymetabolic syndrome (PMS) and non-insulin-dependent diabetes mellitus ( NIDDM) in the Moscow population. The insertional (I) allele and genotype II of the ACE gene proved to be associated with PMS. A significant difference in allele and genotype frequency distributions of the (CA)n microsatellite of the 3'-untranslated exon of the angiotensinogen gene was revealed between randomly sampled individuals and patients with PMS and IDDM from the Moscow population.
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Authors | O V Miloserdova, N V Perova, M I Balabolkin, P A Slominskiĭ, S A Limborskaia |
Journal | Genetika
(Genetika)
Vol. 37
Issue 10
Pg. 1396-401
(Oct 2001)
ISSN: 0016-6758 [Print] Russia (Federation) |
Vernacular Title | Analiz polimorfnykh variantov genov renin-angiotenzinovoĭ sistemy pri polimetabolicheskom sindrome i insulin-nezavisimom sakharnom diabete. |
PMID | 11761617
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- 3' Untranslated Regions
- Adult
- Alleles
- Diabetes Mellitus, Type 2
(genetics)
- Gene Frequency
- Humans
- Metabolic Syndrome
(genetics)
- Middle Aged
- Moscow
- Mutagenesis, Insertional
- Polymorphism, Genetic
- Renin-Angiotensin System
(genetics)
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