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[Analysis of polymorphic variants of renin-angiotensin system genes in polymetabolic syndrome and non-insulin-dependent diabetes].

Abstract
Polymorphisms of the genes for angiotensin-converting enzyme (ACE) and angiotensinogen, the proteins of the renin-angiotensin system (RAS), were tested for association with the polymetabolic syndrome (PMS) and non-insulin-dependent diabetes mellitus (NIDDM) in the Moscow population. The insertional (I) allele and genotype II of the ACE gene proved to be associated with PMS. A significant difference in allele and genotype frequency distributions of the (CA)n microsatellite of the 3'-untranslated exon of the angiotensinogen gene was revealed between randomly sampled individuals and patients with PMS and IDDM from the Moscow population.
AuthorsO V Miloserdova, N V Perova, M I Balabolkin, P A Slominskiĭ, S A Limborskaia
JournalGenetika (Genetika) Vol. 37 Issue 10 Pg. 1396-401 (Oct 2001) ISSN: 0016-6758 [Print] Russia (Federation)
Vernacular TitleAnaliz polimorfnykh variantov genov renin-angiotenzinovoĭ sistemy pri polimetabolicheskom sindrome i insulin-nezavisimom sakharnom diabete.
PMID11761617 (Publication Type: Journal Article)
Chemical References
  • 3' Untranslated Regions
Topics
  • 3' Untranslated Regions
  • Adult
  • Alleles
  • Diabetes Mellitus, Type 2 (genetics)
  • Gene Frequency
  • Humans
  • Metabolic Syndrome (genetics)
  • Middle Aged
  • Moscow
  • Mutagenesis, Insertional
  • Polymorphism, Genetic
  • Renin-Angiotensin System (genetics)

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