Abstract | BACKGROUND/AIMS: In mammals iron homeostasis is most important, as imbalance of iron such as iron overload may lead to severe diseases. Recently, it has been shown that the iron regulatory protein-1 is partially controlled by nitric oxide and reactive oxygen intermediates, molecules frequently seen in inflammatory events. The aim of the present study was to investigate the effects of impaired iron homeostasis on the interaction of nitric oxide, and reactive oxygen intermediate formation in hepatocytes in a model of acute inflammation. METHODS: RESULTS: CONCLUSIONS: Our results show that the antioxidative effects of iron chelators prevent the formation of toxic Fenton oxidants in severe inflammatory events, which should be considered in the treatment of disorders characterized by an iron imbalance.
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Authors | M Jung, J C Drapier, H Weidenbach, L Renia, L Oliveira, A Wang, H G Beger, A K Nussler |
Journal | Journal of hepatology
(J Hepatol)
Vol. 33
Issue 3
Pg. 387-94
(Sep 2000)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 11019994
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Iron-Regulatory Proteins
- Iron-Sulfur Proteins
- Nitrates
- Nitrites
- Nitro Compounds
- RNA-Binding Proteins
- Reactive Oxygen Species
- Sulfhydryl Compounds
- Superoxides
- peroxynitric acid
- Nitric Oxide
- Hydroxyl Radical
- Iron
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
- Nos2 protein, rat
- Glutathione
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Topics |
- Animals
- Glutathione
(metabolism)
- Gram-Positive Bacterial Infections
(metabolism, pathology)
- Hepatitis, Viral, Animal
(metabolism, pathology, virology)
- Hydroxyl Radical
(metabolism)
- Iron
(metabolism)
- Iron-Regulatory Proteins
- Iron-Sulfur Proteins
(metabolism)
- Liver
(metabolism, pathology)
- Male
- Nitrates
(metabolism)
- Nitric Oxide
(metabolism)
- Nitric Oxide Synthase
(metabolism)
- Nitric Oxide Synthase Type II
- Nitrites
(metabolism)
- Nitro Compounds
(metabolism)
- Propionibacterium acnes
- RNA-Binding Proteins
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species
(metabolism)
- Sulfhydryl Compounds
(metabolism)
- Superoxides
(metabolism)
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