Anaphase-Promoting Complex-Cyclosome

An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.

Also Known As:

Networked: 127 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Teodoro, Jose G: 5 articles (01/2019 - 04/2005)
2.	Jackson, Peter K: 5 articles (04/2008 - 07/2004)
3.	Harkness, Troy A A: 4 articles (06/2018 - 10/2004)
4.	Wäsch, Ralph: 3 articles (01/2021 - 01/2005)
5.	Wan, Lixin: 3 articles (01/2019 - 04/2014)
6.	Lehman, Norman L: 3 articles (04/2008 - 07/2006)
7.	Engelhardt, Monika: 2 articles (01/2021 - 12/2013)
8.	Felthaus, Julia: 2 articles (01/2021 - 12/2013)
9.	Follo, Marie: 2 articles (01/2021 - 12/2013)
10.	Schnerch, Dominik: 2 articles (01/2021 - 12/2013)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Recent studies uncovered the emerging roles of SAPCD2 (suppressor anaphase-promoting complex domain containing 2) in several types of human cancer. " 10/04/2022 - "By sequencing families with hereditary cancer, Chen and colleagues report two novel heterozygous mutations in CDC20, a coactivator of the anaphase-promoting complex (APC/C) and a target of the spindle assembly checkpoint (SAC) that prevents chromosome missegregation during mitosis. " 08/30/2022 - "Microarrays performed on mRNAs gathered through longitudinal tumor sampling identified a 290 gene set that was enriched in Anaphase Promoting Complex (APC) substrates and additional mRNAs associated with slowed mitotic progression in MDR samples compared to skin controls. " 01/01/2020 - "The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression." 01/01/2020 - "Cell division cycle associated 5 (CDCA5), a substrate of the anaphase-promoting complex, was reported to be upregulated in several types of cancer; however, the function of CDCA5 in BC remains unclear. "
2.	Aneuploidy (Aneuploid) 04/01/2017 - "In the present study we used live cell imaging microscopy to assess the effects of suboptimal culture temperature on various aspects of IVM, including duration of meiosis I, dynamics of polar body extrusion, chromosome congression, anaphase-promoting complex/cyclosome (APC/C) activation and aneuploidy. " 02/25/2016 - "The spindle checkpoint senses unattached kinetochores and inhibits the Cdc20-bound anaphase-promoting complex or cyclosome (APC/C), to delay anaphase, thereby preventing aneuploidy. " 03/18/2014 - "The spindle assembly checkpoint (SAC) prevents aneuploidy by coupling anaphase onset, through anaphase-promoting complex (APC) activation, with chromosome attachment to spindle microtubules. " 03/17/2014 - "In this paper, we find that MAPK and Cdk1 play compensatory roles to suppress the anaphase-promoting complex/cyclosome (APC/C) activity early in prometaphase, thereby allowing accumulation of APC/C substrates essential for meiosis I. Furthermore, inhibition of MAPK around the onset of APC/C activity at the transition from meiosis I to meiosis II led to accelerated completion of meiosis I and an increase in aneuploidy at metaphase II. These effects appear to be mediated via a Cdk1/MAPK-dependent stabilization of the spindle assembly checkpoint, which when inhibited leads to increased APC/C activity. " 12/01/2012 - "The mitotic checkpoint is an important mechanism that prevents aneuploidy by restraining the activity of the anaphase-promoting complex (APC). "
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/01/2013 - "This suggests that repression of BubR1 in acute myeloid leukemia renders the spindle assembly checkpoint-mediated inhibition of the anaphase-promoting complex insufficient, which facilitates completion of mitosis in the presence of spindle poison. " 01/01/2022 - "Our previous study showed 1 altered circRNA named circ-anaphase promoting complex subunit 7 (ANAPC7) that was upregulated in acute myeloid leukemia (AML). "
4.	Vascular Diseases (Vascular Disease) 10/01/2019 - "This study showed that apoER2 participates in APC (anaphase-promoting complex)/CDC20 complex formation during mitosis, and its absence impedes cytokinesis abscission thereby accelerating premature cell senescence and vascular disease. "
5.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2019 - "Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability." 01/01/2019 - "To evaluate the role of PLK1 as potential cancer target within a combinatorial trial, we induced strong mitotic arrest in ovarian cancer cell lines by synergistically co-targeting microtubules (paclitaxel) and PLK1 (BI6727) followed by pharmaceutical inhibition of the Anaphase-Promoting Complex (APC/C) using proTAME. "

Related Drugs and Biologics

1.	Ubiquitin
2.	Ligases (Synthetase)
3.	Proteins (Proteins, Gene)
4.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
5.	Paclitaxel (Taxol)
6.	Anaphase-Promoting Complex-Cyclosome Apc7 Subunit
7.	Circular RNA
8.	Proteasome Endopeptidase Complex (Proteasome)
9.	Securin
10.	Cyclin B1

Related Therapies and Procedures

1.	Therapeutics
2.	Castration