rho Guanine Nucleotide Dissociation Inhibitor beta

A rho GDP-dissociation inhibitor subtype that is highly expressed in hematopoietic cells and in LYMPHOCYTES. The expression of this subtype is associated with the regulation of CELL PROLIFERATION; TUMORIGENESIS; and APOPTOSIS.

Also Known As:

Networked: 82 relevant articles (1 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Theodorescu, Dan: 15 articles (12/2016 - 11/2002)
2.	Yoo, Jiyun: 9 articles (01/2022 - 04/2009)
3.	Baek, Kyoung Eun: 8 articles (10/2014 - 04/2009)
4.	Cho, Hee Jun: 8 articles (10/2014 - 04/2009)
5.	Kim, In-Kyu: 7 articles (10/2014 - 04/2009)
6.	Nam, In-Koo: 7 articles (10/2014 - 04/2009)
7.	Park, Sun-Mi: 7 articles (10/2014 - 04/2009)
8.	Ryu, Ki-Jun: 6 articles (01/2022 - 10/2011)
9.	Hong, Soon-Chan: 6 articles (10/2014 - 09/2010)
10.	Park, Seung-Ho: 6 articles (10/2014 - 10/2011)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "Functional role of Rho GDP-dissociation inhibitor beta (RhoGDIβ) in tumor biology appears to be contradictory across various studies. " 05/01/2023 - "Although RhoGDI2 is oversubscribed in several cancer categories, the effect of RhoGDI2 in HL-60 cells has remained unexplained. " 02/16/2023 - "This review sheds a light on the dual opposite role of RhoGDI2 in cancer, highlights its underappreciated role in immunity and proposes ways to explain its intricate regulatory functions." 02/16/2023 - "RhoGDI2 has been implicated in multiple human cancers and immunity regulation, where it can display a dual role. " 02/16/2023 - "The Dual Function of RhoGDI2 in Immunity and Cancer."
2.	Urinary Bladder Neoplasms (Bladder Cancer) 03/01/2015 - "Finally, unbiased transcriptome analysis revealed a set of genes regulated by RhoGDI2 overexpression and RhoC knockdown in bladder cancer cells. " 03/01/2015 - "RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer." 04/01/2012 - "Low expression of RhoGTP dissociation inhibitor 2 (RhoGDI2; also known as ARHGDIB and Ly-GDI) is associated with metastatic disease in patients with muscle-invasive bladder cancer. " 12/01/2009 - "In this review, we will discuss the established roles of c-Src and RhoGDI2 in bladder cancer and speculate on their therapeutic relevance." 09/01/2007 - "Using a similar strategy of gene identification by concordance of microarray gene expression results from cells expressing RhoGDI2 and human bladder cancers, two molecular effectors of RhoGDI2 signaling were identified. "
3.	Neoplasm Metastasis (Metastasis) 11/01/2014 - "In the present study, we investigated the RhoGDI2 expression level in HCC tissues and the function of RhoGDI2 in HCC cell growth and metastasis. " 03/01/2015 - "Although RhoGDI2 functions as a metastasis regulator, little is known in glial cells under neuropathological conditions. " 12/01/2009 - "Interestingly, c-Src bound to and phosphorylated RhoGDI2 resulting in enhanced metastasis suppressive potency. " 04/07/2009 - "Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function." 04/01/2009 - "Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases."
4.	Stomach Neoplasms (Stomach Cancer) 01/05/2022 - "We previously showed that RhoGDI2 positively regulates Rac1 activity and Rac1 activation is critical for RhoGDI2-induced gastric cancer cell invasion. " 11/01/2020 - "Knockdown of RhoGDI2 represses human gastric cancer cell proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1 pathway." 01/01/2015 - "RhoGDI2 was correlated with P-gp expression in gastric cancer tissues as detected by immunohistochemistry. " 01/01/2015 - "Here, we reported RhoGDI2 also induced MDR in gastric cancer cell line (MKN-45). " 10/01/2014 - "We also show that RhoGDI2 positively regulates Rac1 activity in gastric cancer cells. "
5.	Lung Neoplasms (Lung Cancer) 01/01/2014 - "The aim of this study was to evaluate the function of RhoGDI2 in lung cancer epithelial-mesenchymal transition (EMT) process and to illustrate the underlying mechanisms that will lead to improvement of lung cancer treatment. " 01/01/2015 - "Erratum to: RNA interference-mediated knockdown of RhoGDI2 induces the migration and invasion of human lung cancer A549 cells via activating the PI3K/Akt pathway." 01/01/2015 - "Verifying the role and molecular mechanism of the participation of RhoGDI2 in the migration and invasion of lung cancer may provide a target for better treatment. " 01/01/2015 - "This result suggests that the down-regulated RhoGDI2 contributed to the migration and invasion of the lung cancer cell line via activating the PI3K/Akt pathway and the ensuing increase in the expression and activity of MMP-9. " 01/01/2015 - "However, the underlying mechanism and effector targets of RhoGDI2 in lung cancer are still not fully understood. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	rho Guanine Nucleotide Dissociation Inhibitor beta
3.	Actins (F Actin)
4.	rho Guanine Nucleotide Dissociation Inhibitor alpha
5.	Cisplatin (Platino)
6.	Small Interfering RNA (siRNA)
7.	Fluorouracil (Carac)
8.	Guanosine Diphosphate (GDP)
9.	Filamins
10.	Vascular Endothelial Growth Factor C

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Cystectomy
4.	Gastrectomy