Lente Insulin

An insulin, zinc chloride preparation in the form of a suspension of crystals and amorphous material in a ratio of approximately 7:3. Typically, lente insulin has a duration of activity that lasts between 13-20 hours after dosage.

Also Known As:

Networked: 36 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Bonfanti, Ugo: 2 articles (01/2018 - 10/2008)
2.	Carotenuto, Gaia: 1 article (01/2018)
3.	Corradini, Sara: 1 article (01/2018)
4.	D'Angelo, Simona: 1 article (01/2018)
5.	Del Baldo, Francesca: 1 article (01/2018)
6.	Di Cunzolo, Antonella: 1 article (01/2018)
7.	Fracassi, Federico: 1 article (01/2018)
8.	Linari, Guido: 1 article (01/2018)
9.	Malerba, Eleonora: 1 article (01/2018)
10.	Antony, Jesmin: 1 article (10/2014)

Related Diseases

1.	Diabetes Mellitus 06/01/1995 - "Effect of lente insulin for treatment of diabetes mellitus in 12 cats." 04/01/1979 - "[Treatment of juvenile diabetes mellitus with purified insulin (Monotard)]." 03/01/1957 - "Lente insulin in the treatment of diabetes mellitus." 02/02/1957 - "[Treatment of diabetes mellitus with insulin lente]." 09/20/1980 - "Her diabetes mellitus was difficult to control during the hyperthyroid state but it was under good control with monocomponent lente insulin (36u/day) when the euthyroid state was resumed."
2.	Hypoglycemia (Reactive Hypoglycemia) 09/01/2005 - "Lente insulin doses had to be reduced (50-75 U/kg per day) for CRH KO mice to survive repeated hypoglycemia. " 09/01/2005 - "To develop a mouse model of recurrent hypoglycemia, we first tested the effects of daily lente insulin injection on counterregulatory responses to acute hypoglycemia in male C57BL/6 mice. " 09/01/2005 - "Wild-type (WT) mice treated with 50 to 75 U/kg per day lente insulin exhibited enhanced sympathetic activity after hypoglycemia, resembling the compensatory responses associated with impaired glucose homeostasis in C57BL/6 mice treated with 250 U/kg per day lente insulin. " 09/01/2005 - "Treatment with up to 250 U/kg per day lente insulin resulted in significantly greater decreases in plasma glucose, suggestive of impaired counterregulation, after hypoglycemia induced by acute insulin injection. " 07/01/1989 - "In the 50% of patients who completed the study, it appeared that significant improvements in glycemic control could be achieved by simple basal-rate intravenous insulin infusion compared with conventional treatment with single daily injections of ultralente or lente insulin without an increased incidence of symptomatic hypoglycemia."
3.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/01/1984 - "The aim was to study the effect of dose on subcutaneous absorption of semisynthetic human Lente-type insulin (Monotard HM) in IDDM patients. " 06/01/1995 - "Twelve cats with insulin-dependent diabetes mellitus were treated with lente insulin. " 12/01/1990 - "Fifty two children with insulin dependent diabetes mellitus were randomised to receive human isophane or lente insulin preparations in combination with soluble insulin in a double blind trial. " 10/01/2014 - "Randomized controlled trials or non-randomized studies of long acting (glargine, detemir) and intermediate acting (neutral protamine Hagedorn (NPH), lente) insulin for adults with type 1 diabetes were included. " 03/01/2009 - "Insulin glargine is associated with greater reductions in glucose variability than NPH/Lente insulin in pediatric patients with type 1 diabetes."
4.	Body Weight (Weight, Body) 02/01/1985 - "After an overnight fast 0.4 U of intermediate acting insulin (Monotard MC/NOVO INDUSTRIES) per kg body weight were injected subcutaneously. " 09/01/2007 - "STZ+insulin-treated group C diabetic rats were additionally treated with subcutaneous injections of lente insulin (0.5 U/kg body weight) daily from Day 10 to Day 30 of our 40-day study period. " 11/01/2008 - "Six cats that required a maximum lente insulin dosage >or=1.5 IU/kg body weight per injection had pituitary enlargement and 5 of these cats had acromegaly. "
5.	Hyperglycemia 01/01/1992 - "Lente insulin was administered every day to control hyperglycemia, except for the days for studies. " 12/01/1993 - "Because the present therapeutic regimens of NPH/Lente insulin given at suppertime cause overnight hyperinsulinemia, excessive fasting hyperglycemia rarely follows nocturnal hypoglycemia, except when excessive glucose is ingested to correct hypoglycemia. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Insulin Glargine (Lantus)
3.	Glucose (Dextrose)
4.	Isophane Insulin (NPH Insulin)
5.	Zinc
6.	Protamines (Protamine Sulfate)
7.	Pork Regular Insulin (Velosulin)
8.	Suspensions
9.	Lente Insulin
10.	Blood Glucose (Blood Sugar)

Related Therapies and Procedures

1.	High-Protein Low-Carbohydrate Diet (Atkins Diet)
2.	Injections
3.	Glycemic Control
4.	Subcutaneous Injections
5.	Therapeutics