Further support for inhibition of endogenous insulin secretion by exogenous insulin.

Abstract

In order to investigate whether or not insulin exerts any influence on endogenous insulin secretion, 6 non-obese healthy volunteers were connected to the artificial beta-cell (BIOSTATOR) for 16 hours. After an overnight fast 0.4 U of intermediate acting insulin (Monotard MC/NOVO INDUSTRIES) per kg body weight were injected subcutaneously. The computer program was set to maintain steady-state plasma glucose concentrations at fasting levels by a variable glucose infusion. This approach is able to prevent completely hypoglycemic episodes. Endogenous insulin secretion was evaluated by measuring plasma C-peptide concentrations. Whereas plasma insulin levels increased markedly in response to insulin injection at the same time C-peptide levels declined correspondingly, indicating an inhibition of insulin secretion. Thus, our results provided further support for a negative feedback regulation of insulin secretion by insulin itself.

• Authors: K P Ratzmann, B Schulz
• Journal: Experimental and clinical endocrinology (Exp Clin Endocrinol) Vol. 85 Issue 1 Pg. 75-80 (Feb 1985) ISSN: 0232-7384 [Print] Germany
• PMID: 3886414 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• C-Peptide
• Insulin
• Insulin Antagonists
• Glucose

Topics

• Adult
• Blood Glucose (analysis)
• C-Peptide (blood)
• Feedback
• Glucose
• Humans
• Hypoglycemia (prevention & control)
• Insulin (blood, metabolism, pharmacology)
• Insulin Antagonists (pharmacology)
• Insulin Secretion