|1.||Supriatno,: 6 articles (01/2011 - 10/2002)|
|2.||Cleveland, John L: 5 articles (09/2014 - 04/2003)|
|3.||Pellegata, Natalia S: 5 articles (03/2013 - 07/2007)|
|4.||Yoshida, Hideo: 5 articles (09/2005 - 10/2002)|
|5.||Sato, Mitsunobu: 5 articles (09/2005 - 10/2002)|
|6.||Harada, Koji: 5 articles (09/2005 - 10/2002)|
|7.||Viglietto, Giuseppe: 4 articles (03/2012 - 10/2002)|
|8.||Nakayama, Keiichi I: 4 articles (03/2010 - 08/2005)|
|9.||Fusco, Alfredo: 4 articles (09/2007 - 10/2002)|
|10.||Loda, Massimo: 4 articles (04/2007 - 06/2003)|
01/01/2005 - "p27(kip1) protein downregulation is usually achieved by proteasomal degradation and is often correlated to a worse prognosis in several types of human cancers, resulting in the reduction of disease free and overall survival. "
05/01/2001 - "Recent studies have reported that a decreased p27kip1 protein (p27) expression is associated with aggressive tumor behavior in several human malignancies. "
07/01/1997 - "The aims of this study were 1) to establish the pattern of expression of p27KIP1 protein in nontumor lymphoid tissue, 2) to determine whether p27KIP1 is involved in lymphomagenesis, and 3) to address the possible relationship between p27KIP1 and p21WAF1 expression in reactive and tumor lymphoid tissue. "
11/15/2015 - "Disruption of this protein-protein interaction results in higher levels of CDK inhibitor p27, which can act as a tumor suppressor. "
06/01/2015 - "The cyclin-dependent kinase inhibitor p27(Kip1) is known to act as a putative tumor suppressor in several human cancers, including cervical cancer. "
10/01/2000 - "The expression of the cyclin-dependent kinase inhibitor p27(KIP1) characterizes early-stage and well-differentiated carcinomas of the colon, breast, and prostate and is associated with an improved prognosis. "
06/30/2003 - "Recent studies have demonstrated that jab1 contributes to carcinoma progression by degrading p27/Kip1 protein. "
04/01/2003 - "The objective of this study was to clarify the prognostic and predictive value of immunoreactivity for the cyclin-dependent kinase inhibitor p27(Kip1) in patients with early-stage breast carcinoma and to investigate its relation with clinicopathologic features and other markers. "
04/01/1999 - "The purpose of this study was to assess p27(Kip1) protein expression in normal and benign prostatic epithelia as well as the possible existence of abnormalities in prostate carcinoma progression. "
03/01/2013 - "Expression of p27Kip1 protein in gastric carcinoma."
|3.||Colorectal Neoplasms (Colorectal Cancer)
01/01/1999 - "This study explores the prognostic significance of the absence of the p27Kip1 protein in patients with colorectal cancer (CRC). "
06/01/2009 - "Energy balance and the AKT pathway are important in colorectal cancer development and regulate p27 (cyclin-dependent kinase inhibitor-1B/CDKN1B/KIP1), which plays a role in preventing cell cycle progression. "
01/01/2009 - "p27Kip1 protein expression, as evaluated by western blotting, was absent or reduced in about 63% of colorectal cancers compared with both peritumoral and normal tissue. "
05/01/2002 - "Expression of the cyclin-dependent kinase inhibitor p27(Kip1) (p27) is frequently reduced in human colorectal cancer, and this correlates with poor patient prognosis. "
01/01/1999 - "Absence of the cell cycle inhibitor p27Kip1 protein predicts poor outcome in patients with stage I-III colorectal cancer."
|4.||Prostatic Neoplasms (Prostate Cancer)
11/01/2001 - "This study confirms the independent prognostic value of decreased p27Kip1 protein expression in patients with localized prostate cancer, while a prognostic importance of p21Waf/Cip in addition to established patients' and tumour characteristics like tumour stage and histological grading appears rather unlikely."
01/01/2011 - "Depletion of USP19 inhibited proliferation in prostate cancer DU145, PC-3 and 22RV1 cells, which was similar to the pattern established in fibroblasts in that it was due to decreased progression from G1 to S phase and associated with a stabilization of the cyclin-dependent kinase inhibitor p27(Kip1). "
09/01/2008 - "P27(kip1) protein, however, was detected in all low Gleason score prostate cancers, but it was found in only 7/13 high score cases. "
12/07/2004 - "In human prostate cancer, the frequent down-regulation of p27(kip1) protein expression is correlated with poor clinical outcome, yet p27(kip1) rarely undergoes mutational inactivation. "
02/01/2004 - "[Correlation of Skp2 and P27kip1 protein expression and clinicopathological features of prostate cancer]."
08/01/2000 - "In conclusion, the study suggests that reduced expression of p27kip1 protein may play a role in the pathogenesis and biologically aggressive behavior of malignant lymphomas."
09/01/2014 - "Expression and subcellular localization of cyclin-dependent kinase inhibitor p27 does not correlate with proliferation pattern of mantle lymphoma cells."
03/25/2011 - "Here we show that ablation of the Map1s gene in mice caused reduction in the B-cell CLL/lymphoma 2 or xL (Bcl-2/xL) and cyclin-dependent kinase inhibitor 1B (P27) protein levels, accumulation of defective mitochondria, and severe defects in response to nutritive stress, suggesting defects in autophagosomal biogenesis and clearance. "
04/01/2003 - "Emu-Myc transgenic mice lacking one or both E2f1 alleles exhibited a slower onset of lymphoma development associated with increased expression of the cyclin-dependent kinase inhibitor p27(Kip1) and a reduced S phase fraction in precancerous B cells. "
04/01/2000 - "Overall, these data show that PELs consistently express p27(Kip1) protein despite the high proliferative rate of the lymphoma clone, suggesting that p27(Kip1) may be unable to drive cell-cycle arrest in PEL cells. "
|4.||Messenger RNA (mRNA)
|5.||Proteins (Proteins, Gene)
|7.||Cell Cycle Proteins
|9.||Progesterone Receptors (Progesterone Receptor)
|1.||Drug Therapy (Chemotherapy)
|4.||Heterologous Transplantation (Xenotransplantation)
|5.||Lymph Node Excision (Lymph Node Dissection)