14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid.

Abstract	Jun activation domain-binding protein 1 (jab1) is known as a coactivator of the AP1 transcription factor. Recent studies have demonstrated that jab1 contributes to carcinoma progression by degrading p27/Kip1 protein. In this study, we immunohistochemically investigated jab1 expression in thyroid neoplasms. jab1 overexpression tended to be frequently observed in follicular carcinoma compared to adenoma. Larger-sized papillary carcinoma overexpressed jab1 in higher incidence than microcarcinomas (1.0 cm or less in maximum diameter). In anaplastic carcinoma, jab1 was more frequently overexpressed than in papillary and follicular carcinomas. An inverse relationship was detected between jab1 overexpression and p27 expression in papillary and anaplastic carcinomas, but not in follicular tumor. These results suggest that jab1 plays a role in the progression of thyroid carcinomas, especially those of aggressive phenotypes, and it may be responsible for p27 degradation in anaplastic and papillary carcinomas.
Authors	Yasuhiro Ito, Eiji Miyoshi, Erika Uda, Hiroshi Yoshida, Takashi Uruno, Yuuki Takamura, Akihiro Miya, Kaoru Kobayashi, Fumio Matsuzuka, Nariaki Matsuura, Kennichi Kakudo, Kanji Kuma, Akira Miyauchi
Journal	Cancer letters (Cancer Lett) Vol. 196 Issue 1 Pg. 87-91 (Jun 30 2003) ISSN: 0304-3835 [Print] Ireland
PMID	12860294 (Publication Type: Journal Article)
Chemical References	14-3-3 Proteins Biomarkers, Tumor DNA-Binding Proteins Intracellular Signaling Peptides and Proteins Microfilament Proteins Muscle Proteins Neoplasm Proteins Tagln protein, mouse Transcription Factors Exonucleases Exoribonucleases SFN protein, human Peptide Hydrolases COPS5 protein, human Cops5 protein, mouse COP9 Signalosome Complex
Topics	14-3-3 Proteins Adenocarcinoma, Follicular (metabolism) Adenoma (metabolism) Biomarkers, Tumor COP9 Signalosome Complex Carcinoma, Papillary (metabolism) DNA-Binding Proteins (metabolism) Exonucleases (metabolism) Exoribonucleases Humans Intracellular Signaling Peptides and Proteins Microfilament Proteins (metabolism) Muscle Proteins Neoplasm Proteins Peptide Hydrolases Thyroid Neoplasms (metabolism) Transcription Factors (metabolism)

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