|1.||Largaespada, David A: 6 articles (02/2015 - 08/2004)|
|2.||Dupuy, Adam J: 4 articles (01/2013 - 12/2008)|
|3.||McIvor, R Scott: 4 articles (01/2011 - 12/2004)|
|4.||Bigot, Yves: 4 articles (05/2010 - 01/2003)|
|5.||Ehrhardt, Anja: 3 articles (01/2015 - 11/2010)|
|6.||Zhang, Wenli: 3 articles (01/2015 - 11/2010)|
|7.||Copeland, Neal G: 3 articles (11/2009 - 12/2008)|
|8.||Jenkins, Nancy A: 3 articles (11/2009 - 12/2008)|
|9.||Bigot, Y: 3 articles (08/2006 - 04/2000)|
|10.||Simmons, Michael J: 3 articles (12/2002 - 05/2002)|
10/15/2015 - "Our results demonstrate that CRISPR/Cas9 combined with piggyBac transposase lineage labeling can produce unique models of neurodevelopmental disruption and tumors caused by somatic mutation in neural progenitors. "
10/15/2015 - "The CRISPR/Cas9 system allows for such targeted mutagenesis, and we therefore tested it in combination with a piggyBac transposase lineage labeling system to track the development of neocortical neural progenitors with targeted mutations in genes linked to neurodevelopmental disruptions and tumor formation. "
02/01/2015 - "This system uses a conditionally expressed transposase and mutagenic transposon allele to target mutagenesis to somatic cells of a given tissue in mice to cause random mutations leading to tumor development. "
11/19/2010 - "PiggyBac transposition in genetically engineered transposon-transposase mice induced cancers whose type (hematopoietic versus solid) and latency were dependent on the regulatory elements introduced into transposons. "
04/01/2010 - "We demonstrate that T cells electroporated to introduce the PB transposon and transposase stably express CD19-specific CAR and when cultured on CD19(+) artificial antigen-presenting cells, numerically expand in a CAR-dependent manner, display a phenotype associated with both memory and effector T cell populations, and exhibit CD19-dependent killing of tumor targets. "
08/01/2011 - "This result agrees with previous studies supporting the use of transposons in heterologous organisms to prevent from genomic instability and from impeding the precise activity of the exogenous transposase."
01/01/2015 - "Nine copies of the rRNA gene operon and multiple transposase genes with identical sequences resulted in breaks in the original draft genome and may suggest genomic instability of JBW45. "
01/01/2011 - "These procedures should prevent transposase-mediated remobilization of the transgenes, ensuring their genomic stability."
10/01/2010 - "The transposase gene may integrate very rarely and randomly into genomes, which has led to concerns that continued expression might support continued remobilization of transposons and genomic instability. "
09/01/2004 - "This procedure prevents transposase-mediated remobilization of the other terminal sequence and associated genes, ensuring their genomic stability."
05/01/2006 - "Using this approach, low therapeutic levels of FVIII ( approximately 10%), as well as phenotypic correction of the bleeding disorder, were achieved in all animals that received the FVIII transposon and functional transposase throughout the duration of the study (24 weeks). "
09/01/2014 - "Remarkably, only very low transposon/transposase doses were required to cure the bleeding diathesis. "
|5.||Colonic Neoplasms (Colon Cancer)
01/01/2014 - "Potential role for the Metnase transposase fusion gene in colon cancer through the regulation of key genes."
12/01/2013 - "OBJECTIVE-MATERIALS AND METHODS: In this particular study, it was determined the relative gene expression of Notch receptors after knockdown experiments in colon cancer stem cells (CSCs) and the gene expression changes in stemness transcription factors (Oct4, Sox2, Nanog), as well in dipeptidylpeptidase-4, CD44 antigen, Met proto-oncogene and in Metnase transposase. "
|1.||DNA (Deoxyribonucleic Acid)
|2.||lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)
|7.||Transcription Factors (Transcription Factor)
|9.||DNA Transposable Elements (Element, IS)
|10.||Staphylococcal Protein A (A, Protein)