Triptorelin Pamoate (Trelstar)

A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE with D-tryptophan substitution at residue 6.

Also Known As:

Trelstar; 6-D-Tryptophan-Luteinizing Hormone-Releasing Factor (Pig); AY-25650; CL-118532; Decapeptyl; Decapeptyl Depot; Decapeptyl LP; Decapeptyl Trimestral; GnRH, Trp(6)-; LHRH, Tryptophyl(6)-; Triptorelin Embonate; Wy-42462; AY 25650; AY25650; CL 118532; CL118532; Embonate, Triptorelin; Pamoate, Triptorelin; Trimestral, Decapeptyl; Wy 42462; Wy42462; D-Trp-6-LH-RH; LHRH, Trp(6)-; Triptorelin; 5-oxo-Pro-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2

Networked: 455 relevant articles (46 outcomes, 112 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Cabri, Patrick: 9 articles (10/2023 - 10/2014)
2.	Emons, Günter: 9 articles (01/2008 - 02/2002)
3.	Gründker, Carsten: 9 articles (01/2008 - 02/2002)
4.	Günthert, Andreas R: 7 articles (01/2008 - 03/2002)
5.	Ferrero, Simone: 5 articles (09/2015 - 01/2007)
6.	Remorgida, Valentino: 5 articles (09/2015 - 01/2007)
7.	Maggi, Mario: 4 articles (12/2023 - 11/2002)
8.	Vignozzi, Linda: 4 articles (12/2023 - 11/2002)
9.	Maisonobe, Pascal: 4 articles (01/2020 - 10/2014)
10.	Baroncelli, Giampiero I: 4 articles (07/2018 - 01/2009)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 06/01/2015 - "The improvement in LUTS in men with locally advanced or metastatic prostate cancer after 24-48 weeks suggests that triptorelin is effective in improving LUTS in this subgroup of patients." 05/01/1999 - "Decapeptyl Depot, administered subcutaneously or intramuscularly was effective and safe in the treatment of patients with advanced prostate cancer." 03/01/2024 - "Data were pooled from three prospective, 9-12-month Phase III studies of triptorelin monotherapy in patients with advanced prostate cancer (including NCT00751790). " 12/01/2018 - "Effects of Initiating or Switching to a Six-Monthly Triptorelin Formulation on Prostate Cancer Patient-Healthcare Interactions and Hospital Resource Use: a Real-World, Retrospective, Non-Interventional Study." 06/01/2015 - "This study demonstrates that triptorelin pamoate 11.25 mg administered by the subcutaneous route every 3 months is as efficacious and well tolerated as administration via the intramuscular route in men with locally advanced or metastatic prostate cancer."
2.	Precocious Puberty 01/29/2024 - "Long-term efficacy of triptorelin 3-month depot in girls with central precocious puberty." 08/30/2021 - "Efficacy of Triptorelin 3-Month Depot Compared to 1-Month Depot for the Treatment of Korean Girls with Central Precocious Puberty in Single Tertiary Center." 07/01/2015 - "To evaluate the long-term efficacy of triptorelin 3.75 mg subcutaneously every 6 weeks on the final height in girls with idiopathic central precocious puberty (ICPP). " 12/01/1998 - "Efficacy of the subcutaneous reformulated triptorelin depot in children with central precocious puberty." 10/01/2023 - "Efficacy and Safety of Triptorelin 3-Month Formulation in Chinese Children with Central Precocious Puberty: A Phase 3, Open-Label, Single-Arm Study."
3.	Endometriosis 07/30/2021 - "Symptom control after different duration of triptorelin treatment following conservative surgery for deep infiltrating endometriosis: Post-hoc analysis of a multicentre, prospective, real-world study." 06/01/2014 - "This review offers an explanation of the mechanism of action, of the pharmacokinetics and pharmacodynamics of triptorelin and gives the readers a complete overview of the studies on the clinical efficacy, tolerability and safety of this agent in patients with endometriosis. " 02/01/2008 - "A randomized study comparing triptorelin or expectant management following conservative laparoscopic surgery for symptomatic stage III-IV endometriosis." 10/01/2022 - "Assessment of Two Formulations of Triptorelin in Chinese Patients with Endometriosis: A Phase 3, Randomized Controlled Trial." 07/30/2021 - "Triptorelin has been used after surgery in deep infiltrating endometriosis. "
4.	Pain (Aches) 01/01/2023 - "An extended-interval dosing regimen of a 3.75 mg depot formulation of triptorelin injected every 6 weeks instead of every 4 weeks reduces the cost by one-third without compromising the effect on pain relief. " 07/30/2021 - "Evolution in score of pain intensity at 3, 6, 9, 12, 18, and 24 months after primary triptorelin administration and symptom improvement/recurrence rates between two groups were compared. " 04/01/1998 - "Triptorelin reduces endometriotic lesions and pain to a significantly higher degree than placebo." 04/01/1998 - "Pain symptoms according to both scales were significantly more reduced after 2 months of triptorelin treatment compared to placebo. " 06/01/2014 - "The studies reviewed in the current manuscript demonstrate the efficacy of triptorelin in improving pain symptoms caused by endometriosis. "
5.	Neoplasms (Cancer) 01/01/2021 - "Our results demonstrated the lack of cellular cytotoxicity of SPION@CMD@triptorelin, and it could increase the cellular uptake of SPIONs to MDA-MB-231 cancer cells 6.50-fold greater than to SPION@CMD at the concentration of 75 μM. " 10/01/2019 - "Since the tumor had arisen during pregnancy, triptorelin was administered after delivery. " 01/01/2018 - "From 2009 to 2015, 373 cancer patients underwent MII oocyte cryopreservation after IVM cycles primed either with GnRHa (triptorelin 0.2 mg) (n = 138) or hCG (10,000 IU) (n = 235). " 05/01/1999 - "Three of the patients treated with triptorelin alone experienced tumor regression compared with four patients in the combination group. " 09/15/1990 - "The effects of Decapeptyl treatment on tumor induction and tumor growth were studied in normal or ovariectomized 6-week-old nude mice inoculated with 10(7) plaque-forming units Py virus (day 0 of experiments). "

Related Drugs and Biologics

1.	Gonadotropin-Releasing Hormone (GnRH)
2.	Testosterone (Sustanon)
3.	Leuprolide (Lupron)
4.	Hormones (Hormone)
5.	Triptorelin Pamoate (Trelstar)
6.	Acetates (Acetic Acid Esters)
7.	Danazol (Azol)
8.	dienogest
9.	Gonadotropins
10.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)

Related Therapies and Procedures

1.	Therapeutics
2.	Castration
3.	Aftercare (After-Treatment)
4.	Hysterectomy
5.	Ovariectomy (Oophorectomy)