Endometriosis

A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.

Also Known As:

Networked: 13947 relevant articles (1036 outcomes, 2961 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Pelvic Pain
3.	Infertility (Sterility)
4.	Dysmenorrhea (Menstrual Pain)
5.	Endometriosis

Experts

1.	Osuga, Yutaka: 92 articles (11/2022 - 03/2003)
2.	Taylor, Hugh S: 90 articles (01/2022 - 05/2004)
3.	Guo, Sun-Wei: 83 articles (06/2022 - 01/2004)
4.	Ferrero, Simone: 81 articles (01/2022 - 01/2004)
5.	Vercellini, Paolo: 74 articles (07/2022 - 01/2002)
6.	Somigliana, Edgardo: 67 articles (07/2022 - 03/2002)
7.	Koga, Kaori: 65 articles (11/2022 - 07/2003)
8.	Chapron, Charles: 62 articles (01/2022 - 11/2002)
9.	Petraglia, Felice: 61 articles (10/2022 - 04/2002)
10.	Hirota, Yasushi: 56 articles (11/2022 - 07/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Endometriosis:

1.	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/01/2018 - "Among the drugs under investigation, late clinical trials on gonadotropin-releasing hormone antagonists (GnRH-ant) showed the most promising results for the treatment of endometriosis. " 04/01/1989 - "Two of the five patients became pregnant during cycles 2 and 5. From these results, we conclude that continuous sc infusion of GnRH-A is highly effective for complete suppression of the pituitary-ovarian function in patients with endometriosis. " 12/01/2022 - " administration of GnRH-a before IUI treatment is beneficial for patients suffering from stage I-II endometriosis.After" 03/01/1998 - "Use of preoperative gonadotropin-releasing hormone (GnRH) agonists may be beneficial in the case of laparoscopic surgery for large endometriomas. " 08/01/1990 - "In cases of endometriosis and uterus myomatosus, GnRH agonists achieve high remission rates and may avoid or at least postpone the need for surgical intervention. "
2.	dienogestFDA Link 10/01/2018 - "We hereby report the clinical case of a cerebral localization of endometriosis treated with dienogest who experienced a complete remission of the disease." 10/01/2018 - "Complete remission of cerebral endometriosis with dienogest: a case report." 10/01/2018 - "This study aimed to assess whether dienogest (DNG) is also effective in patients with recurrent endometriosis based on multicenter data of 121 women who were clinically diagnosed as having recurrent endometriosis and treated for more than 24 weeks with DNG (2 mg daily). " 11/01/2023 - "Dienogest is superior to placebo and similar to GnRHa in decreasing rate of recurrence after endometriosis surgery. " 01/01/2022 - "Results suggest that TCM combined with Dienogest is superior to Dienogest or TCM alone and can be used as a complementary treatment for endometriosis. "
3.	Danazol (Azol)FDA LinkGeneric 03/01/1989 - "Although the high pretreatment level of serum CA 125 decreased after danazol treatment of 400 mg/day to within the normal limits, usually within 4 to 12 weeks, laparoscopic examinations indicated that most of the endometriosis cases were not cured until 12-16 weeks of danazol treatment." 07/01/1976 - "Nineteen of the 40 patients in the study had a secondary diagnosis of pelvic endometriosis confirmed histologically, and all these patients showed a marked improvement of symptoms during the Danazol treatment. " 10/15/1981 - "The results of large clinical studies suggest that danazol treatment produces significant improvement in the symptoms, signs, and laparoscopic findings of endometriosis. " 11/01/1990 - "This review suggests that endometrioma of the intestine requires a high index of suspicion for diagnosis and that danazol does not appear to be effective treatment for these patients." 09/01/1985 - "In a series of 51 patients with endometriosis, who underwent laparoscopy, then received Danazol, 800 mg daily for 6 months, and had a repeat laparoscopy, there was a statistically significant improvement in the AFS score in Stage I and II disease."
4.	Progestins (Progestagens)IBA 03/05/2021 - "Having reviewed the most significant papers, we can confirm that OCPs and progestogens are effective in two-thirds of women suffering from endometriosis, but that other options are required in case of failure (in one-third of women due to progesterone resistance) or intolerance to these compounds. " 08/01/2015 - "For over 50 years, oral progestins have been demonstrated to be effective in the treatment of endometriosis. " 12/01/2009 - "Oral progestins have been reported to be effective in the treatment of endometriosis. " 03/01/2007 - "Endometriosis-associated symptomatology can be safely and effectively treated with intrauterine-released progestin, which is associated with fewer adverse effects than other therapeutic options and may be used on a long-term basis. " 01/01/2020 - "Efficacy of Different Progestins in Women With Advanced Endometriosis Undergoing Controlled Ovarian Hyperstimulation for in vitro Fertilization-A Single-Center Non-inferiority Randomized Controlled Trial."
5.	Estrogens (Estrogen)FDA Link 09/01/2018 - "Changes in diet, mainly to vegetable consumption, are beneficial in the treatment of estrogen-related pathologies but their use for endometriosis has been poorly studied. " 06/01/2013 - "It is well established that endometriosis grows and regresses in an estrogen-dependent fashion and the disease can be effectively cured by definitive surgery. " 01/01/2020 - "[Efficacy of black cohosh extracts for improving low estrogen status induced by postoperative GnRHa treatment in patients with endometriosis: a systematic review]." 01/01/2003 - "The efficacy of anti-estrogens for endometriosis, an estrogen-dependent disorder, has not been demonstrated. " 11/14/2023 - "This case-control study of reproductive-age women utilizes their fecal and urine samples for enzymatic, microbial, and metabolic studies to explore if patients with endometriosis have distinguishable gut microbiota or altered estrogen metabolism. "
6.	Hormones (Hormone)IBA 01/01/2003 - "Gonadotrophin-releasing hormone analogues (GnRHas) are generally well tolerated, and are effective in relieving the symptoms of endometriosis (Prentice 2003). " 03/01/1995 - "Intraspinal endometriosis was confirmed by gynecological demonstration of additional endometriosis of the left ovary as well as positive response to treatment with a gonadotrophin releasing hormone analog. " 12/01/2023 - "This surgical technique can reliably create hormone-responsive endometriosis in macaques for therapeutic studies." 01/01/2022 - "Long-term hormone treatment products in this study are generally safe for endometriosis, while newly detected signals need to be validated by further exploration. " 01/01/2022 - "Analysis of Adverse Events and Medical Errors in Long-Term Hormone Treatments for Endometriosis: A Study Based on the US Food and Drug Administration Event Reporting System."
7.	Oral ContraceptivesIBA 09/01/2019 - "The use of the oral contraceptive pill as an adolescent and feeling an improvement in symptoms with treatment as an adolescent were found to be associated with a diagnosis of endometriosis.Conclusion" 11/01/2015 - "Efficacy of Long-Term Post-Operative Oral Contraceptive Use for the Prevention of Endometrioma Recurrence in Adolescents." 01/01/2014 - "We compared the efficacy of postoperative use of LNG-IUS with oral contraceptives (OC) for preventing endometrioma recurrence. " 11/01/2013 - "To evaluate the efficacy of continuous oral contraceptive (OC) use versus the usual cyclic fashion in the recurrence of endometriosis-related symptoms after surgery. " 01/01/2019 - "Continuous oral contraceptives versus long-term pituitary desensitization prior to IVF/ICSI in moderate to severe endometriosis: study protocol of a non-inferiority randomized controlled trial."
8.	Leuprolide (Lupron)FDA LinkGeneric 03/01/2015 - "Leuprolide acetate is effective and safe in the treatment of endometriosis." 04/01/2019 - "There are limited studies investigating the use of leuprorelin for the treatment of endometriosis in Asian populations. " 04/01/2019 - "This review includes randomised trials of women with endometriosis treated with leuprorelin in Asia. " 04/01/2019 - "Clinical studies investigating the use of leuprorelin in Asian women with endometriosis: a review." 05/01/2016 - "This study was funded by AbbVie, which also markets the endometriosis drugs Lupron and Lupaneta Pack. "
9.	Levonorgestrel (Plan B)FDA LinkGeneric 09/01/2018 - "After surgery for endometriosis, a CHC or 52mg levonorgestrel-releasing IUS is recommended as first-line treatment when pregnancy is not desired. " 01/01/2017 - "The objective of the study was to evaluate whether a maintenance levonorgestrel-releasing intrauterine system is effective for preventing postoperative endometrioma recurrence. " 01/01/2022 - "To explore the therapeutic efficacy of the levonorgestrel-releasing intrauterine system combined with turtle shell decocted pills for endometriosis and their effect on cellular immune function. " 09/01/2018 - "Comparison of the efficacy of diegnogest and levonorgestrel-releasing intrauterine system after laparoscopic surgery for endometriosis." 07/01/2011 - "The levonorgestrel (LNG) intrauterine system (LNG-IUS) has been shown to improve symptoms in women with minimal to moderate endometriosis. "
10.	Biomarkers (Surrogate Marker)IBA 01/01/2023 - "Finally, C3 and VCAM1 were highly expressed in endometriosis tissue samples compared with controls and may be potential biomarkers of endometriosis, which are helpful for the early diagnosis of endometriosis." 01/01/2021 - "Analyzing menstrual fluid from women with endometriosis for inflammatory markers and other biomarkers may also be beneficial for earlier diagnosis and disease staging." 01/01/2016 - "HE4 can be a very useful biomarker to exclude malignant disease in patients with endometriosis." 12/01/2023 - "To investigate the efficacy of new endometriosis biomarkers in diagnosis and treatment. " 05/01/2016 - "-two studies evaluated 97 biomarkers that did not differentiate women with endometriosis from disease-free controls. "

Therapies and Procedures

1.	Therapeutics 07/01/2014 - "The optimal management of thoracic endometriosis needs further evaluation but the combined approach by hormonal therapy and surgery could be the best option." 05/01/1999 - "Although hormonal suppression often is the therapy of choice in extrapelvic endometriosis, we think surgical excision, respecting the anatomical fiber architecture of the anal sphincter, is the best treatment for perianal endometriosis. " 12/01/2017 - "Defining whether medical therapy is effective in women with deep rectovaginal endometriosis and in which circumstances it can be considered an alternative to surgery is important for patients and physicians. " 04/01/2011 - "Taken together, our data indicate an important role for bone marrow-derived endothelial cells in the pathogenesis of endometriosis and support the potential clinical use of anti-angiogenic therapy as a novel treatment modality for this disease." 03/01/2002 - "Finally, the combination of in vitro fertilization and either medical or surgical therapy may be beneficial with advanced endometriosis, but further study is required."
2.	Cystectomy 06/01/2006 - "Partial cystectomy gives the best results when used to treat bladder endometriosis. " 08/01/2021 - "Applying haemostatic sealant after laparoscopic cystectomy of ovarian endometriomas produces a significantly greater improvement in AFC, which was apparent at 3-month follow-up, and was sustained at 1-year follow-up without compromising the recurrence rate." 01/01/2016 - "Salpingo-oopherectomy and cystectomy for endometrioma cause a significant reduction in AMH levels. " 01/01/2012 - "Endometrioma cystectomy leads to significant reduction in ovarian parenchyma volume and AFC, when compared to contra lateral ovary. " 06/09/2011 - "Both ovarian endometrioma and cystectomy are associated with a significant reduction on ovarian reserve. "
3.	Hysterectomy 01/01/1998 - "Quality evaluation and improvement in practice: Abdominal hysterectomy with or without adnexectomy for endometriosis. " 05/26/2023 - "With regard to the first aim of the review, we found 32 eligible studies and divided these into the following four categories: postoperative short- and long-term outcomes, recurrence of endometriosis, quality of life and sexual function, and patient satisfaction after total or subtotal hysterectomy in women with endometriosis. " 06/01/2022 - "This is the first study that focuses on parametrial endometriosis using validated questionnaires to assess functional outcomes following radical hysterectomy for DE." 05/01/2022 - "Patients undergoing a benign hysterectomy between 2015 and 2017 in Sweden were included in the study and were grouped according to a histology-proven diagnosis of endometriosis. " 01/01/2022 - "Comparing Characteristics of and Postoperative Morbidity after Hysterectomy for Endometriosis versus other Benign Indications: A NSQIP Study."
4.	Lasers (Laser) 01/01/2007 - "Endometriosis in the RV pouch and RV septum can be effectively treated with laser laparoscopy performed by experienced endoscopic gynaecologists." 05/01/1997 - "Laser laparoscopy is a practical, safe, and effective technique for the management of large ovarian endometriomas." 02/01/1997 - "Efficacy of isotopic 13CO2 laser laparoscopic evaporation in the treatment of infertile patients with minimal and mild endometriosis: a life table cumulative pregnancy rates study." 02/01/1997 - "To assess the efficacy of 13CO2 laser laparoscopy in treating infertile women with minimal to mild endometriosis according the American Fertility Society classification in terms of pregnancy rates. " 09/01/1995 - "Treatment of endometriosis by laser laparoscopy improved both fertilization (51% versus 56%) and early embryonic development rates (46% versus 58%). "
5.	Laparotomy 01/01/2020 - "Despite its high prevalence, the diagnosis of some patients with endometriosis is delayed for several years, which may be because the gold standard for diagnosis is an expensive and invasive surgical assessment by laparoscopy or laparotomy. " 07/01/1992 - "Our results validate the therapeutic efficacy of operative laparoscopy in the treatment of moderate and severe endometriosis and confirm the substantial economic and social benefits of laparoscopy surgery over laparotomy." 12/01/2015 - "The gold standard in the diagnosis of intestinal endometriosis is exploratory laparotomy and the pathological study of specimens. " 01/01/2020 - "Though laparoscopy is considered the 'gold standard'of endometriosis surgery, laparotomy still may be indicated in patients with extensive endometriosis especially to preserve reproductive function." 04/01/2015 - "To investigate the recurrence rate and disease-free interval between laparoscopy versus laparotomy for the conservative surgery of endometrioma. "