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Aflatoxin B1 (Aflatoxin B)

A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
Also Known As:
Aflatoxin B; Aflatoxin B1 Dihydrochloride, (6aR-cis)-Isomer; Aflatoxin B1, (6aR-cis)-Isomer, 14C-Labeled; Aflatoxin B1, (6aR-cis)-Isomer, 2H-Labeled; Aflatoxin B1, (6aR-cis)-Isomer, 3H-Labeled; Aflatoxin B1, cis(+,-)-Isomer; HSDB-3453; NSC-529592; HSDB 3453; HSDB3453; NSC 529592; NSC529592; Aflatoxin B(1); Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-
Networked: 1058 relevant articles (17 outcomes, 120 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Groopman, John D: 21 articles (01/2020 - 10/2002)
2. Egner, Patricia A: 12 articles (01/2020 - 02/2003)
3. Santella, Regina M: 12 articles (01/2018 - 09/2006)
4. Ma, Yun: 12 articles (10/2017 - 10/2005)
5. Kensler, Thomas W: 11 articles (11/2017 - 02/2003)
6. Long, Xi-Dai: 10 articles (06/2018 - 10/2010)
7. Huang, Xiao-Ying: 9 articles (06/2018 - 11/2011)
8. Yao, Jin-Guang: 9 articles (06/2018 - 11/2011)
9. Wu, Hui-Chen: 8 articles (01/2018 - 05/2007)
10. Essigmann, John M: 8 articles (11/2017 - 05/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Hepatocellular Carcinoma (Hepatoma)
3. Carcinogenesis
4. Liver Neoplasms (Liver Cancer)
5. Infections

Related Drugs and Biologics

1. Aflatoxins
2. Biomarkers (Surrogate Marker)
3. DNA Adducts
4. Mycotoxins
5. Proteins (Proteins, Gene)
6. oltipraz
7. Amines
8. Transferases
9. Serum Globulins
10. Curcumin

Related Therapies and Procedures

1. Chemoprevention
2. Injections
3. Diet Therapy (Therapy, Diet)
4. Lasers (Laser)
5. Hepatectomy