Aflatoxins

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943 relevant articles (24 outcomes, 100 trials/studies) found for this Bio-Agent

Description: Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.

Also Known As:

Aflatoxin

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 25

Experts

1.	Groopman, John D: 3 articles (08/2005 - 11/2004)
2.	Kensler, Thomas W: 3 articles (08/2005 - 11/2004)
3.	Santella, Regina M: 2 articles (07/2007 - 02/2003)
4.	Chen, Chien-Jen: 2 articles (07/2007 - 02/2003)
5.	Ahsan, Habibul: 2 articles (07/2007 - 02/2003)
6.	Massey, Thomas E: 2 articles (09/2006 - 01/2003)
7.	Ma, Yun: 2 articles (09/2006 - 09/2005)
8.	Lii, C K: 2 articles (04/2006 - 05/2001)
9.	Sheen, L Y: 2 articles (04/2006 - 05/2001)
10.	Turner, Paul C: 2 articles (02/2005 - 12/2002)

Related Diseases

1.	Body Weight (Weight, Body) 10/01/1993 - "Results showed that chicks receiving aflatoxin-contaminated feed had suppressed body weight (456 g), which significantly improved (516 g) with the inclusion of .1% S. " 01/01/1994 - "Additionally, the supplements' mixture improved the body weight and the relative weight of the liver comparing with the chicks fed on the aflatoxin diet without additives. " 01/01/1998 - "The effect of a subclinical dose of aflatoxin on body weight gain and risk assessment of aflatoxin in muscle tissue for food safety were the focus of the study. " 06/01/2009 - "After acclimation, the birds were challenged with B1 aflatoxin (3 mg/kg body weight for 2 consecutive days) by oral gavage. " 10/01/2008 - "In one of them, quails were orally administered with aflatoxin in dose of 0.04 mg/kg body weight previously. " Order ALL the reference details at left...
2.	Liver Neoplasms (Liver Cancer) 09/01/2006 - "With improved accuracy and precision, this sensitive biomarker for recent human exposure to AFB(1) will be especially useful for measuring the efficacy of planned interventions to reduce aflatoxin-related liver cancer in AFB(1)-exposed populations." 03/01/1992 - "Risk modeling is used to assess the dose-response relationship between aflatoxin exposure and primary liver cancer, controlling for hepatitis B virus (HBV), based on data provided by the Yeh et al. study in China. " 09/01/1991 - " There is good experimental evidence that aflatoxin acts as an initiator for liver cancer, but there is not practical way to judge exposure for clinical studies." 12/01/1990 - "A review of epidemiology literature revealed that only studies conducted in Africa and Asia included data adequate to permit quantitative assessment of the dose-response relationship between aflatoxin exposure levels and liver cancer rates. " 12/01/1990 - "These studies demonstrate that induced GST expression occurs in some small populations of hepatocytes, but not in larger advanced stages of malignant progression of aflatoxin- or PAH-induced hepatic neoplasms in rainbow trout." Order ALL the reference details at left...
3.	Neoplasms (Cancer) 01/01/1976 - "The 53-wk study showed clearly that light decreased the incidence of aflatoxin-induced cancer. " 08/01/1996 - "Protection against aflatoxin B1-induced hepatic toxicity as short-term screen of cancer chemopreventive dithiolethiones." 02/01/2005 - "In this study, we sought to determine the contributions of these agents by measuring the occurrence of an HBV 1762(T)/1764(A) double mutation, an aflatoxin-specific 249(G-->T) mutation of the p53 gene, and HCV in plasma of 34 HCC cases and 68 age- and gender-matched controls, and in 25 liver tumors from northern Thailand. " 02/01/1996 - "These studies have been hindered by the lack of adequate dosimetry data on aflatoxin intake, excretion, and metabolism in people, as well as by the general poor quality of worldwide cancer morbidity and mortality statistics. " 02/01/1993 - "Biochemical and histochemical studies were conducted in aflatoxin B1-induced liver tumors in adult rainbow trout. " Order ALL the reference details at left...
4.	Hepatocellular Carcinoma (Hepatoma) 09/01/2008 - "Aflatoxins as a risk factor for hepatocellular carcinoma in Egypt, Mansoura Gastroenterology Center study." 09/01/2005 - "[A study about the association of detoxication gene GSTM1 polymorphism and the susceptibility to aflatoxin B1-related hepatocellular carcinoma]" 03/08/1999 - "More strikingly, the relationship between aflatoxin exposure and development of human hepatocellular carcinoma (HHC) was demonstrated by the studies on the p53 tumor suppressor gene. " 01/01/1998 - "This study investigated whether aflatoxin contamination of peanut products may contribute to the incidence of hepatocellular carcinoma (HCC) in Sudan. " 08/01/1997 - "In humans, studies of individual biomonitoring of AFB1 metabolites such as AFB1-N7-guanine have demonstrated that aflatoxins constitute an important risk factor for hepatocellular carcinoma (HCC) in exposed populations. " Order ALL the reference details at left...
5.	Hepatitis B 10/01/2006 - "The second comprises a more 'permissive' liberal approach involving the initial study of an individual compound, and subsequent interrogation of that compound in combination with another (as demonstrated by lowering the carcinogenicity of aflatoxin by vaccination against hepatitis B). " 01/01/1995 - "This study suggest the validity of aflatoxin-albumin adducts as a marker of chronic exposure to this carcinogen and its importance in relation with the virus of hepatitis B." 04/01/2006 - "Viral hepatitis B and C, alcohol, and aflatoxin are the major established risk factors. " 02/01/2005 - "Hepatitis B and C viruses (HBV and HCV) and aflatoxins are known risk factors for HCC, but the etiological status of these factors in HCC development is not clear. " 08/01/2001 - "Hepatitis B and C viruses (HBV and HCV) and dietary aflatoxin intake remain the major causative factors of HCC. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	oltipraz
2.	Aflatoxin B1 (Aflatoxin B)
3.	Aflatoxins
4.	DNA (Deoxyribonucleic Acid)
5.	Biological Markers (Surrogate Marker)
6.	Smoke
7.	Carcinogens
8.	Cytochromes
9.	Diethylnitrosamine (N-Nitrosodiethylamine)
10.	Alanine Transaminase (SGPT)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Chemoprevention
3.	Oral Administration
4.	Aftercare (After-Treatment)
5.	Transplants (Transplant)

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