Piperacillin

Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.

Also Known As:

AB-Piperacillin; Cl-227193; Pipcil; Pipera-Hameln; Piperacillin Curasan; Piperacillin Fresenius; Piperacillin Hexal; Piperacillin Monosodium Salt; Piperacillin Sodium; Piperacillin-Ratiopharm; Pipercillin; Pipracil; Pipril; T-1220; T1220; AB Piperacillin; Cl 227193; Cl227193; Curasan, Piperacillin; Monosodium Salt, Piperacillin; Pipera Hameln; Piperacillin Ratiopharm; Salt, Piperacillin Monosodium; Sodium, Piperacillin; T 1220; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((((4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta(S*)))-

Networked: 911 relevant articles (103 outcomes, 154 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Roberts, Jason A: 28 articles (03/2022 - 03/2008)
2.	Lipman, Jeffrey: 19 articles (03/2022 - 03/2008)
3.	Roberts, Michael S: 11 articles (01/2018 - 03/2008)
4.	Wallis, Steven C: 9 articles (01/2022 - 07/2013)
5.	Kirkpatrick, Carl M J: 7 articles (01/2023 - 02/2010)
6.	Friberg, Lena E: 7 articles (10/2022 - 01/2018)
7.	Thorsted, Anders: 7 articles (10/2022 - 01/2018)
8.	Verstraete, Alain G: 7 articles (01/2022 - 05/2014)
9.	Öbrink-Hansen, Kristina: 6 articles (03/2023 - 11/2015)
10.	Scharf, Christina: 6 articles (01/2023 - 04/2016)

Related Diseases

1.	Infections 11/01/1982 - "Evidence from prospective studies indicates that piperacillin is a highly effective agent for the treatment of patients with infections caused by susceptible organisms." 04/01/2011 - "The infection was treated successfully with piperacillin. " 09/01/1991 - "The altered pharmacokinetics of piperacillin during pregnancy suggest that higher doses may be required for effective treatment of serious infections in pregnant women near term." 04/01/1983 - "Piperacillin (PIPC) was employed for prophylactic treatment in 18 patients against postoperative infections and for therapeutic treatment in 3 patients against complicated infections of urogenital tracts. " 05/01/1982 - "Piperacillin is also effective for bone and joint infections. "
2.	Fever (Fevers) 01/01/2019 - "A total of 482 piperacillin concentrations were obtained from 43 children (aged 1-18 years) during 89 fever episodes. " 10/01/2001 - "At first, piperacillin sodium (PIPC) was started, but a spiking fever persisted. " 04/01/1993 - "A 43-year-old woman was treated with piperacillin (PIPC) for spiking fever. " 01/01/1988 - "Although emergence of resistance was not seen, one isolate had an increase in minimum inhibitory concentration from 8 to 128 micrograms/ml. There were no serious adverse reactions to piperacillin; only one patient developed fever possibly related to piperacillin. " 03/01/1985 - "The fever resolved shortly after the piperacillin treatment was stopped, as did the widespread rashes in the two patients who developed them. "
3.	Critical Illness (Critically Ill) 08/01/2006 - "Results from our study demonstrated that the clinical efficacy of piperacillin as a continuous infusion is superior to intermittent administration in critically ill patients. " 11/26/2021 - "Furthermore, the efficacy of the proposed dosing target of piperacillin in critically ill patients was evaluated. " 03/24/2022 - "Objectives: This study aimed to develop a piperacillin population PK model for critically ill Brazil-ian patients and describe interethnic variation using an external validation. " 03/25/2021 - "The study supports the use of extended infusions of piperacillin in non-critically ill patients with EBSI. " 01/01/2021 - "This study aimed to determine the most accurate GFR estimation formula for assessing piperacillin clearance in critically ill children, using a published piperacillin pharmacokinetics (PK) population model. "
4.	Urinary Tract Infections (Urinary Tract Infection) 01/01/1986 - "[Clinical studies of efficacy of piperacillin against complicated urinary tract infections]." 09/01/1988 - "[Reevaluation of clinical efficacy of piperacillin against complicated urinary tract infections]." 01/01/1986 - "Clinical efficacy of piperacillin against 74 cases with complicated urinary tract infection was examined. " 01/01/1984 - "We do not recommend piperacillin alone for empiric treatment of complicated urinary tract infections." 07/01/1982 - "The efficacy and tolerance of parenterally administered piperacillin were evaluated in 50 adult patients hospitalized with systemic and urinary tract infections. "
5.	Neutropenia 01/01/2007 - "This review sought to assess the occurrence of piperacillin-induced neutropenia, describe characteristics of affected patients and assess the reporting modalities that most accurately classify this ADR. " 01/01/2007 - "Systematic review of piperacillin-induced neutropenia." 01/01/2022 - "The mean cumulative dose of piperacillin was 290.4 g among patients who experienced neutropenia and 247.0 g among all patients treated with P/T, and the mean treatment duration was 24.0 days and 21.0 days, respectively. " 01/01/2007 - "Report of neutropenia associated with piperacillin usage prior to 15 days of therapy is a novel finding that requires further evaluation. " 08/15/1989 - "The efficacy of piperacillin was therefore reconfirmed for the management of infection in oncologic patients with neutropenia, and proved to be an effective therapeutic resource in patients with both slight and severe neutropenia."

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Tazobactam
3.	Gentamicins (Gentamicin)
4.	Tobramycin (Nebcin)
5.	Amikacin (A.M.K)
6.	Ciprofloxacin (Cipro)
7.	Penicillins (Penicillin)
8.	Aztreonam
9.	Sulbactam
10.	Imipenem

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Continuous Renal Replacement Therapy
4.	Antibiotic Prophylaxis
5.	Renal Replacement Therapy (Therapies, Renal Replacement)