Abstract |
A 43-year-old woman was treated with piperacillin (PIPC) for spiking fever. Although she was afebrile, fever recurred on the 18th day of PIPC administration with progressive dyspnea and diffuse ground glass shadows on the chest X-ray. Bronchoalveolar lavage fluid (BALF) showed marked increase of total cell number and percentage of lymphocytes and a reduction of the ratio of CD4/CD8. Transbronchial lung biopsy (TBLB) specimen revealed interstitial infiltration of lymphocytes and histiocytes with granulomatous lesions. The drug lymphocyte stimulation test (DLST) was positive for PIPC. Based on these findings, the diagnosis of PIPC-induced pneumonitis was made. Recently, the incidence of drug-induced pneumonitis has increased, but to our knowledge this is a rare case report of PIPC-induced pneumonitis.
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Authors | M Inoue, S Tanigawa, M Masutani, T Horie |
Journal | Nihon Kyobu Shikkan Gakkai zasshi
(Nihon Kyobu Shikkan Gakkai Zasshi)
Vol. 31
Issue 4
Pg. 530-3
(Apr 1993)
ISSN: 0301-1542 [Print] Japan |
PMID | 8515628
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adult
- Female
- Humans
- Piperacillin
(adverse effects)
- Pneumonia
(chemically induced)
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