Pharmacokinetics of piperacillin during pregnancy.

The pharmacokinetics of piperacillin during pregnancy were investigated. Eight pregnant women received 4 g of piperacillin intravenously before caesarean section. Likewise, five non-pregnant subjects of child bearing age received the same dose before a gynaecological operation. The mean peak plasma concentrations of piperacillin were 87.5 and 172.2 mg/L for the pregnant and non-pregnant patients, respectively. The mean umbilical vein concentration was 9.7 mg/L; the mean umbilical artery concentration was 7.4 mg/L and the amniotic fluid concentration 6.8 mg/L. The feto-maternal ratio at the time of caesarean section was 0.27. Pharmacokinetic parameters of piperacillin indicate larger volumes of distribution and higher clearance rates during pregnancy compared with the non-pregnant state. The altered pharmacokinetics of piperacillin during pregnancy suggest that higher doses may be required for effective treatment of serious infections in pregnant women near term.
AuthorsA Heikkilä, R Erkkola
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 28 Issue 3 Pg. 419-23 (Sep 1991) ISSN: 0305-7453 [Print] ENGLAND
PMID1960122 (Publication Type: Journal Article)
Chemical References
  • Piperacillin
  • Adult
  • Female
  • Half-Life
  • Humans
  • Maternal-Fetal Exchange
  • Piperacillin (pharmacokinetics)
  • Pregnancy (metabolism)

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