|2.||Head and Neck Neoplasms (Head and Neck Cancer)
|4.||Wounds and Injuries (Trauma)
|1.||Nabili, Vishad: 6 articles (06/2014 - 04/2010)|
|2.||Rogers, S N: 4 articles (04/2014 - 02/2002)|
|3.||Støre, G: 4 articles (03/2005 - 10/2000)|
|4.||Wolff, Klaus-Dietrich: 3 articles (11/2015 - 11/2012)|
|5.||Delanian, S: 3 articles (12/2014 - 02/2002)|
|6.||Wax, Mark K: 3 articles (12/2014 - 11/2008)|
|7.||Walter, Christian: 3 articles (12/2014 - 10/2006)|
|8.||Akintoye, Sunday O: 3 articles (10/2014 - 05/2010)|
|9.||Morris, Christopher G: 3 articles (03/2014 - 06/2007)|
|10.||Mendenhall, William M: 3 articles (03/2014 - 06/2007)|
03/01/2011 - "Based on weak evidence, prophylactic hyperbaric oxygen is effective in reducing the risk of developing osteoradionecrosis after post-radiation extractions."
03/01/1987 - "Hyperbaric oxygen (HBO) therapy is an established technology that is proving to be effective in the treatment of osteoradionecrosis. "
04/01/2008 - "The influence of hyperbaric oxygen on the outcome of patients treated for osteoradionecrosis: 8 year study."
09/01/2007 - "The influence of hyperbaric oxygen on the outcome of patients treated for osteoradionecrosis: 8 year study."
08/01/2005 - "Because of the evolution of this new idea, as well as a double-blinded, placebo-controlled study finding no benefit from the use of hyperbaric oxygen for advanced osteoradionecrosis of the mandible, new treatment considerations have emerged. "
|2.||Pentoxifylline (Trental)FDA LinkGeneric
11/01/2004 - "The efficacy of combined pentoxifylline-tocopherol treatment in superficial RIF was confirmed in a randomised clinical trial, and then in successful phase II trials especially in uterine fibroatrophy and osteoradionecrosis. "
11/01/2015 - "The efficacy of pentoxifylline/tocopherol combination in the treatment of osteoradionecrosis."
11/01/2010 - "Studies of the use of pentoxifylline and α-tocopherol in osteoradionecrosis of the jaw have suggested their efficacy in this condition. "
02/01/2014 - "Pentoxifylline and tocopherol have been used in the treatment of osteoradionecrosis for many years, with observed lesion improvement. "
01/01/2014 - "New approach for the treatment of osteoradionecrosis with pentoxifylline and tocopherol."
11/01/2011 - "While osteoradionecrosis (ORN) of the temporal bone has been reported previously in patients with nasopharyngeal carcinoma, this is the first time it has been presented in the context of an ELST. "
09/01/2011 - "Differentiating osteoradionecrosis from nasopharyngeal carcinoma tumour recurrence using ⁹⁹Tcm-sestamibi SPECT/CT."
08/01/2009 - "Tl-201 SPECT in clarifying false positive FDG PET findings caused by osteoradionecrosis in a case of nasopharyngeal carcinoma."
11/01/2008 - "Fourteen post-irradiation nasopharyngeal carcinoma patients (n = 14 ears) with diffuse osteoradionecrosis received surgical treatment from March 1994 to May 2005. "
11/01/2008 - "Surgical treatment of osteoradionecrosis of the temporal bone in patients with nasopharyngeal carcinoma."
|5.||Dental Implants (Dental Implant)IBA
06/01/2013 - "Low-intensity ultrasound can accelerate the healing of bone tissues surrounding dental implants in osteoradionecrosis of the mandible animals."
05/01/2010 - "Therapists involved in radiation planning should consider the impact of dental implants on the radiation beam as a putative cause of osteoradionecrosis."
12/01/2008 - "[Osteoradionecrosis and dental implants]."
06/01/2005 - "Total dose that may lead to osteoradionecrosis risk of the mandible is slightly but not significantly affected by the scattered dose of the dental implants of lower jaw in the radiation field exposed to 3 different radiation beams."
06/01/2013 - "To investigate whether low-intensity ultrasound accelerates healing in bone tissues close to dental implants with osteoradionecrosis (ORN) of the mandible and is suitable for development as a therapy in patients with dental implants receiving radiotherapy. "
|6.||Anti-Bacterial Agents (Antibiotics)IBA
01/01/1986 - "Conventional treatment of osteoradionecrosis of mandible is by antibiotics combined if necessary with a hemimandibulectomy. "
12/01/1973 - "[3 cases of osteoradionecrosis of the mandible treated with antibiotics with or without gammaglobulins]."
07/01/1985 - "A prospective randomized trial comparing hyperbaric oxygen and systemic antibiotics in the prevention of osteoradionecrosis was presented. "
03/01/2006 - "To critically analyze controversial osteoradionecrosis (ORN) prevention techniques, including preradiation extractions of healthy or restorable teeth and the use of prophylactic antibiotics or hyperbaric oxygen (HBO) treatments for preradiation and postradiation extractions. "
07/01/1995 - "In the treatment of 29 patients with osteoradionecrosis of the mandible, a combination of surgical debridement, antibiotics, and hyperbaric oxygen was used in 27 cases. "
12/01/1996 - "The prophylactic use of HBO has shown to prevent the development of osteoradionecrosis after tooth removal and the loss of titanium implants in irradiated facial bones. "
06/01/2012 - "Radical resection with reconstruction by free tissue flap is recommended for the treatment of jaw osteoradionecrosis, and scaling and reconstruction only with titanium plate should be avoided because of high risks of titanium exposure and disease relapse."
01/01/2006 - "For the different radiation beams studied, the irradiation angle between scattering titanium dental implants and the central axis does not significantly affect the total dose that may lead to osteoradionecrosis of the mandible."
01/01/1991 - "The results show that there were no significant changes in cell survival at the interface between the tissue equivalent medium and titanium support indicating that a dose increase induced by backscatter radiation, which possibly could demolish the osseointegration or induce osteoradionecrosis, are minimal when high energy photons or range modulated protons are applied."
01/01/2006 - "In this study, quantification of backscatter doses between scattering titanium dental implant and the thermoluminescent dosimeter (TLD(100)) radiation detector at axial beam irradiation-angle range of 0-90 degrees in head and neck radiotherapy is done to evaluate irradiation angle dependency of dose enhancement contributing to osteoradionecrosis. "
|8.||Clodronic Acid (Clodronate)IBA
07/01/2011 - "Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial."
05/01/2002 - "Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate."
04/01/2015 - "To review the conservative and surgical management options of osteoradionecrosis, in particular, highlighting the recent the use of anti-radiation fibrosis drugs (pentoxifylline, tocopherol and clodronate). "
04/01/2010 - "Medical treatments may be sufficient for early stages of osteoradionecrosis (antibiotics, pain killers, non-steroidal anti-inflammatory drugs as well as clodronate, vitamin E, pentoxifyllin). "
|9.||glucuronyl glucosamine glycan sulfate (Vessel)IBA
10/01/2013 - "Despite the observation in prior studies of minimal vessel damage in this setting, the hypothesis of this study is that in the late setting of most salvage surgical therapy, either for recurrence or osteoradionecrosis, a different, progressive level of vessel injury may be encountered. "
06/01/2013 - "Salvage of free-flaps in vessel-depleted mandibular osteoradionecrosis cases using catheter-directed thrombolysis and angioplasty."
09/01/1996 - "These changes affect the central nervous system (focal necrosis, diffuse white matter injury, atrophy, mineralizing microangiopathy, telangiectasia, optic neuropathy, large vessel vasculopathy), bone (fatty replacement of marrow, osteoradionecrosis, sinus inflammation), and superficial and deep soft tissues and include neoplasia. "
|10.||Amifostine (Ethyol)FDA LinkGeneric
04/01/1990 - "The adequate utilization of hyperbaric oxygen therapy has been shown to be 95% effective in preventing osteoradionecrosis in postirradiated tissues."
11/01/2004 - "Hyperbaric oxygen therapy is a safe and effective treatment modality offering durable relief in the management of radiation-induced osteoradionecrosis either alone or as an adjunctive treatment. "
10/01/2003 - "This study was designed to use our institutional experience with irradiated head and neck patients to evaluate 1) dental extraction incidence and sequelae; 2) those patients who developed osteoradionecrosis via extraction and the efficacy of hyperbaric oxygen therapy; and 3) guidelines for extraction protocols in this population. "
11/01/2010 - "Efficacy of pre- and postirradiation hyperbaric oxygen therapy in the prevention of postextraction osteoradionecrosis: a systematic review."
09/01/2007 - "This study was a retrospective review of treatment outcomes of osteoradionecrosis (ORN) of the mandible over an 8-year period, with specific reference to the role of hyperbaric oxygen therapy (HBOT). "
|2.||Free Tissue Flaps
06/01/2011 - "The purpose of this study was to evaluate outcomes of free flap reconstruction for advanced osteoradionecrosis (ORN) defects and develop an algorithm to guide surgical planning. "
03/01/2011 - "The purpose of this study was to determine factors to predict the success of free flap surgery in the treatment of osteoradionecrosis (ORN). "
04/01/2010 - "The objective of this study was to assess the outcomes, complications, and incidence of disease recurrence of mandibular osteoradionecrosis (ORN) after resection and microvascular free flap reconstruction. "
12/01/2015 - "The fibula is the workhorse free flap for reconstruction in mandibular osteoradionecrosis. "
12/01/2015 - "To conduct a systematic review of the literature investigating the outcomes of free flap reconstruction of the jaw in mandibular osteoradionecrosis and determine the failure rates of different flap tissue. "
01/01/2013 - "The aim of the study was to develop a model for irradiation of the rabbit mandible in order to have a better knowledge of radiotherapy-induced bone alterations and thus a better prevention and treatment of osteoradionecrosis. "
05/01/2012 - "The aim of this study is to analyze implant survival in patients who received radiotherapy treatment for oral malignancies and in patients who had suffered mandibular osteoradionecrosis. "
06/01/2007 - "This study was done to determine if pre-radiotherapy (pre-RT) dental extractions reduce the risk of osteoradionecrosis (ORN). "
12/01/2015 - "Osteoradionecrosis (ORN) is a rare yet well-recognized complication following radiotherapy to the head and neck. "
08/01/2015 - "[The prevention strategy of concurrent extraction and osteoradionecrosis after radiotherapy]."
01/01/2014 - "Serious late toxicity included graft ulceration in one patient and osteoradionecrosis in another patient, both of which underwent surgical reconstruction. "
07/01/2006 - "Nine years later an infected osteoradionecrosis of the mandible emerged which required a continuity-resection with simultaneously performed reconstruction of the mandible using an autologous free transplanted iliac bone graft. "
01/01/1987 - "Nine patients with early phase mandibular osteoradionecrosis received conservative treatment involving closure with mucosal and periosteal graft. "
01/01/1979 - "All efforts must be made, therefore, to limit the consequences, and with this in mind it is possible: -- to perform an uninterrupted resection limited to the alveolar area involved, in early cases of mandibular osteoradionecrosis; -- to reconstitute mandibular continuity with a bone graft in more advanced stages; -- to improve the esthetic appearance with skin and subcutaneous grafts whenever this is necessary. "
12/01/2009 - "The loss of primary grafts due to radiotherapy or osteoradionecrosis can make secondary mandibular reconstruction necessary. "
|5.||Oral Surgery (Maxillofacial Surgery)
07/01/2012 - "In cases where maxillofacial surgery is indicated, the chance of osteoradionecrosis is higher. "
06/01/2010 - "Management of patients at risk of osteoradionecrosis: results of survey of dentists and oral & maxillofacial surgery units in the United Kingdom, and suggestions for best practice."
06/01/2010 - "We aimed to find out whether dental practitioners take specific measures to identify patients who are at risk of osteoradionecrosis (ORN) of the jawbones; how oral and maxillofacial surgery units in the United Kingdom manage patients who have had radiotherapy and require dental extractions, and the evidence behind current practice. "
09/01/2000 - "In oral and maxillofacial surgery, treatment-resistant osteomyelitis and osteoradionecrosis are indications for HBO (according to Undersea and Hyperbaric Medical Society). "
01/01/1989 - "Their utility is well know in maxillofacial surgery, cervico-facial cancerology, ballistics trauma and in the cure of some mandibular osteoradionecrosis. "