Radiation Injuries (Radiation Sickness)

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1505 relevant articles (59 outcomes, 117 trials/studies) found for this Disease

Description: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.

Also Known As:

Radiation Sickness; Radiation Syndromes; Radiation Syndrome; Injuries, Radiation; Injury, Radiation; Radiation Injury; Radiation Sicknesses; Sickness, Radiation; Sicknesses, Radiation; Syndrome, Radiation; Syndromes, Radiation

Relationship Network

Disease Context: Research Results

Disorders of Environmental Origin

Wounds and Injuries: 64547

Radiation Injuries: 1505

Radiation Pneumonitis: 301

Osteoradionecrosis: 219

Radiodermatitis: 119

Acute Radiation Syndrome: 39

Radiation-Induced Neoplasms: 34

Radiation-Induced Leukemia: 23

Experimental Radiation Injuries: 10

Radiation-Induced Abnormalities: 3

Environment and Public Health

Public Health

Radiologic Health

Radiation Effects

Radiation Injuries: 1505

Acute Radiation Syndrome: 39

Experimental Radiation Injuries: 10

Radiation-Induced Abnormalities: 3

Related Diseases

1.	Fibrosis (Cirrhosis)
2.	Neoplasms (Cancer)
3.	Carcinoma (Carcinomatosis)
4.	Vomiting
5.	Cataract (Cataracts)

Experts

1.	Hauer-Jensen, Martin: 5 articles (09/2008 - 11/2003)
2.	Wang, Junru: 4 articles (10/2007 - 11/2003)
3.	Boerma, Marjan: 3 articles (09/2008 - 10/2006)
4.	Stenson, William F: 3 articles (10/2004 - 03/2003)
5.	Feldmeier, J J: 3 articles (01/2004 - 01/2000)
6.	Hampson, N B: 2 articles (01/2007 - 01/2002)
7.	Anant, Shrikant: 2 articles (10/2004 - 03/2003)
8.	Houchen, Courtney W: 2 articles (10/2004 - 03/2003)
9.	Wong, C Shun: 2 articles (05/2004 - 05/2004)
10.	Nordal, Robert A: 2 articles (05/2004 - 05/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Radiation Injuries:

1.	GenisteinIBA 07/01/2008 - "These data suggest that genistein is protective against a range of radiation injuries." 11/01/2009 - "We previously demonstrated that a single subcutaneous (sc) administration of genistein at a non-toxic dose provided protection against acute radiation injury and that the radioprotective effects were associated with multilineage, hematopoietic progenitor cell recovery. " 11/01/2003 - "administration of the flavonoid genistein at non-toxic doses provides protection against acute radiation injury." 07/01/2008 - "Thirty-day survivals after 7.75 Gy were: NR 23%, VR 53%, and GR 92%, indicating significant protection from acute radiation injury by genistein. " Order ALL the reference details at left...
2.	EnzymesIBA 10/01/1992 - "This review presents the roles of some essential metalloelement-dependent enzymes in the maintenance and function of tissues and their responses to radiation injury and gives an account of the observed effects of nontoxic doses of essential metalloelement compounds on protection against radiation damage and its recovery. " 06/01/1964 - "[STUDIES ON THE DISTRIBUTION AND ACTIVITY OF SOME ENZYMES IN THE SMALL INTESTINE MUCOSA DURING DIFFERENT STAGES OF ACUTE RADIATION INJURY.]" 01/01/1963 - "[HISTOCHEMICAL STUDIES ON THE BEHAVIOR OF ENZYMES IN THE LUNGS IN ACUTE RADIATION INJURY AND AFTER LOCAL ROENTGEN IRRADIATION.]" 01/01/1961 - "[Histochemical studies on oxidative enzymes in lung tissue in radiation injury induced by incorporated radioactive substances.]" 01/01/2001 - "These chelates may be useful in facilitating de novo syntheses of essential metalloelement-dependent enzymes required to repair radiation injury. " Order ALL the reference details at left...
3.	Serotonin (5 Hydroxytryptamine)IBA 08/14/1961 - "[Studies on the role of 5-hydroxytryptamine (serotonin) in the pathogenesis of hematological disorders during the course of acute irreversible radiation sickness.]" 09/01/1960 - "[Study of the role of serotonin (5-hydroxytryptamine) in the pathogenesis of acute radiation sickness. " 03/01/1959 - "[Study of the role of serotonin (5-oxytriptamine) in the pathogenesis of acute radiation sickness. " 07/01/1973 - "[Dynamics of changes in serotonin and thrombocyte count in rat blood during the development of acute radiation sickness]" 05/01/1972 - "[Serotonin consumption by thrombocytes in acute radiation sickness]" Order ALL the reference details at left...
4.	CystamineIBA 07/01/1990 - "Cystamine given to rats prior to irradiation with a dose of 8 Gy (LD77/30) ameliorates significantly the severity of radiation sickness and restores spontaneous motor activity by the time of clinical recovery. " 08/01/1960 - "A trial of cystamine in radiation sickness." 05/01/1985 - "The polydeoxyribonucleotide (PDN) level in leukocytes of peripheral blood of rats treated with cystamine adequately reflects the severity and outcome of radiation sickness. " 01/01/1981 - "[Protein metabolic indices in radiation sickness and the administration of cystamine]" 01/01/1977 - "Experiments were performed on the third day after the administration of cystamine, since the author's previous investigations showed that the protective action of cystamine in radiation sickness was strongest at this time. " Order ALL the reference details at left...
5.	Amifostine (Ethyol)FDA LinkGeneric 02/01/1984 - "The efficacy of WR-2721 pretreatment against radiation injury to the growing kidney was evaluated in the weanling mouse. " 06/01/1986 - "Clinical study of the radioprotective effects of Amifostine (YM-08310, WR-2721) on chronic radiation injury." 07/01/2006 - "Radiation injury to the rectum and amifostine." 01/01/2003 - "Amifostine protects both mesenchymal and hematopoietic progenitors against radiation injury, though the level of protection appears to be dependent upon the sensitivities of these progenitor cells to radiation. " 05/01/1994 - "[The effect of gammaphos on the course and outcome of surgical treatment in combined radiation injuries in pigs]" Order ALL the reference details at left...
6.	Captopril (Capoten)FDA LinkGeneric 09/01/1996 - "We conclude that captopril exerts significant functional and structural protection against renal radiation injury. " 12/01/1992 - "Recent reports of the efficacy of captopril in modifying radiation injury of the lung prompted this trial of captopril in treating established radiation nephropathy. " 05/01/1997 - "Although older animals did not appear to benefit from a short course of captopril, these data suggest that the renin-angiotensin system is important in the sequential expression of renal radiation injury, particularly between 3.5 and 9.5 weeks after irradiation." 09/01/1996 - "There was notable reduction in radiation-induced fibrosis in captopril-treated animals in this model, as in experimental lung radiation injury." 11/15/1994 - "PURPOSE: Captopril, an inhibitor of angiotensin I converting enzyme, has been shown to modify radiation damage and prevent radiation injury of normal tissue in rats and pigs. " Order ALL the reference details at left...
7.	Glutathione (Reduced Glutathione)IBA 03/01/1951 - "Relation of clearance and distribution of injected glutathione to protection against radiation injury." 09/01/2007 - "Moreover, we show that SQ20B are protected against radiation injury through a fivefold upper level of endogenous glutathione compared to SCC61. " 05/01/2002 - "In addition, the effects of exogenous glutathione (GSH) against radiation injury in rat livers were investigated. " 05/01/1992 - "The prophylactic effect of glutathione (GSH) on radiation injury in rat parotid glands was investigated. " 09/01/1987 - "[Effect of glutathione on the course of radiation sickness with a marked gastrointestinal syndrome and the effectiveness of parenteral feeding in an experiment]" Order ALL the reference details at left...
8.	Glutamine (L-Glutamine)FDA Link 05/01/1996 - "Glutamine-supplemented polymeric or elemental diets given to rats before, during and after abdominal radiotherapy showed protective effects against radiation injury, by supporting mucosal structure and recovery." 07/01/1994 - "CONCLUSION--Glutamine-supplemented polymeric or elemental diets given to rats before, during and after abdominal radiotherapy showed protective effects against radiation injury, by supporting mucosal structure and recovery." 04/01/1997 - "Effect of enteral glutamine on intestinal permeability and bacterial translocation after abdominal radiation injury in rats." 01/01/1994 - "Comparison of diets with and without the added glutamine showed significant protection of the intestine from radiation injury. " 01/01/1994 - "Protection from radiation injury by elemental diet: does added glutamine change the effect?" Order ALL the reference details at left...
9.	beta Carotene (Betacarotene)FDA Link 12/01/2002 - "At 7 days after radiation, the ratio of necrotic cells in the crypt vs. the total was significantly lower, and the ratio of necrotic cells in the villus vs. the total was significantly greater with beta-carotene administration, which indicated that beta-carotene accelerated recovery from radiation injury. " 12/01/2002 - "It is concluded that pre-, during, and post-radiation administration of beta-carotene protected against radiation injury of the small intestine and accelerated recovery from it." 12/01/2002 - "The protective effect of beta-carotene against radiation injury to the small intestine of abdominally radiated mice (15 Gy) was examined with administration given pre-radiation, during (pre- and post-) radiation, and post-radiation. " 03/01/1992 - "Radio-protective effectiveness of short-term (19 and 4 h before, 4 and 24 h after irradiation), long-term (3 times/week during 30 days after irradiation) and delayed (1 or 2 days after irradiation) enrichment with crystallized beta-carotene, in single doses of 0.1, 1.0 or 5.0 mg was evaluated in experimental acute external gamma-irradiation (0.029 Gy/sec) within the range of absorbed doses 9--6 Gy. The results obtained have permitted the authors to recommend the ration enriched with carotinoid for prevention and therapy of acute radiation injuries." 03/01/1992 - "[Prospects of the use of beta-carotene enriched food products in the prevention and therapy of radiation injuries]" Order ALL the reference details at left...
10.	DNA (Deoxyribonucleic Acid)IBA 01/01/1972 - "[Experimental studies on the optimum conditions in the use of heterologous DNA in treatment of acute radiation sickness in rats]" 11/01/1967 - "[Study of the character of radiation injury of submolecular DNA using the method of hydrodynamic shift]" 01/01/1963 - "[STUDY OF DNA RADIATION INJURIES BY THE THERMAL ROD SEPARATION METHOD.II. THE EFFECT OF IONIZING AND UV RADIATIONS ON THE SEPARATION OF 2-ROD DNA.]" 08/01/2006 - "These data demonstrate a novel biological function of PF4 as a protector against radiation injury and suggest that attenuated Salmonella could be used in vivo as a PF4 DNA delivery vector in the management of radiation injury." 09/01/2005 - "The injection of the phenozane in concentrations causing its receptor interaction with cells, did not defend DNA of the bone marrow cells from the radiation injury after the exposure in a sublethal dose, however it exerted influence on long-term changes. " Order ALL the reference details at left...

Therapies and Procedures

1.	Plasmapheresis 07/01/1994 - "[Experimental study of therapeutic efficacy of plasmapheresis in acute radiation injury]" 07/01/1994 - "In experiments with dogs exposed to 2.9 Gy (LD80/45) it was found that plasmapheresis treatment 4-6 h after irradiation reduce the severity of the radiation sickness clinical manifestations and post-radiation toxemia thus increasing the rate of animal survival up to 60%. " Order ALL the reference details at left...
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 02/01/1964 - "[ON THE INFLUENCE OF ANEMIC BLOOD PLASMA ON THE EFFICACY OF BONE MARROW TRANSPLANTATION IN ACUTE RADIATION SICKNESS.]" 07/01/2001 - "Radiation injury in humans was a major stimulus for research in bone marrow transplantation. " 12/01/1990 - "Therapy of such patients should be developed along the following lines: 1) prevention and therapy of infectious complications: 2) blood cell substitution therapy; 3) bone marrow transplantation; 4) detoxicating therapy; 5) correction of water-electrolyte metabolism; 6) therapy of local radiation injuries." 08/01/1976 - "[Effectiveness of preserved bone marrow transplantation in experimental radiation sickness]" 07/01/1970 - "[Oxidative phosphorylation in spleen mitochondria in acute radiation injury treated by bone marrow transplantation]" Order ALL the reference details at left...
3.	Transplants (Transplant) 01/01/1957 - "Protection against radiation injury by heterologous tissue transplants." 01/01/2007 - "A successful transplant of stem cells and subsequent reduction in radiation-induced complication may open the road to completely new strategies in cutaneous radiation syndrome therapy." 01/01/2007 - "Human mesenchymal stem cells favour healing of the cutaneous radiation syndrome in a xenogenic transplant model." 12/15/2000 - "Although application of the strategy may be limited by the possibility of radiation injury, the results are consistent with the paradigm that we have proposed to explain organ-induced graft acceptance, tolerance, and chronic rejection." 11/01/1990 - "Dermal grafts were placed over the entire length of the arterialized veins to protect them from radiation injury. " Order ALL the reference details at left...
4.	Oral Administration 11/01/2000 - "CONCLUSION: Long-term oral administration of ASA gave only a modest, non-significant reduction of renal radiation injury after clinically relevant fractionated irradiation schedules." 01/01/1960 - "[Experimental data on the investigation of the effect of chlortetracycline for oral administration in various forms of complex therapy of acute radiation sickness.]" 01/01/1955 - "[Oral administration of cystamine in radiation sickness.]" 11/01/2008 - "While irradiation markedly reduced 30-day survival in non-treated control mice, and caused significant bone marrow suppression and intestinal injury in surviving mice, oral administration of WR-1065/PLGA nanoparticles resulted in significant radioprotection as evidenced by a marked reduction in all three of the above mentioned parameters of radiation injury. " Order ALL the reference details at left...
5.	Gamma Cameras (Gamma Camera) 12/01/1977 - "Gamma camera examination of the 99Tcm-DP distribution could not demonstrate any abnormalities, and is concluded not to be effective in demonstrating early radiation injury to bone tissue. " Order ALL the reference details at left...

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