Abstract | OBJECTIVE: While the success of microvascular reconstruction is well established, even in the setting of prior radiotherapy, the outcomes in the setting of prior chemoradiation are less well documented. We present our experience with microvascular reconstruction in a unique cohort of patients previously treated with concomitant hyperfractionated radiation and intra-arterial chemotherapy (HYPERRADPLAT). Despite the observation in prior studies of minimal vessel damage in this setting, the hypothesis of this study is that in the late setting of most salvage surgical therapy, either for recurrence or osteoradionecrosis, a different, progressive level of vessel injury may be encountered. STUDY DESIGN: Case series with chart review. SETTING: Tertiary referral academic medical center practice. SUBJECTS AND METHODS: RESULTS:
Wound breakdown, fistula, or both occurred postoperatively in 50% (4/8) of these patients. No complications of the venous anastomoses occurred. Fifty percent (4/8) of patients required return to surgery for arterial failure due to thrombosis of the anastomosis. Two cases of these flaps could not be salvaged. CONCLUSION: Microvascular reconstruction following HYPERRADPLAT appears to result in a high number of arterial related complications. This experience implies an important delayed treatment effect of HYPERRADPLAT occurs upon recipient arteries. The manner in which this effect may occur in recipient arteries in the setting of more conventional chemoradiation requires further study.
|
Authors | Joseph Valentino, W Brian Helton, Raman Unnikrishnan, Mahesh Kudrimoti, Susanne M Arnold, T J Gal |
Journal | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
(Otolaryngol Head Neck Surg)
Vol. 149
Issue 4
Pg. 541-6
(Oct 2013)
ISSN: 1097-6817 [Electronic] England |
PMID | 23894148
(Publication Type: Journal Article)
|
Chemical References |
- Antineoplastic Agents
- Cisplatin
|
Topics |
- Adult
- Antineoplastic Agents
(administration & dosage)
- Carcinoma, Squamous Cell
(therapy)
- Chemoradiotherapy
- Cisplatin
(administration & dosage)
- Dose Fractionation, Radiation
- Female
- Free Tissue Flaps
(adverse effects)
- Head and Neck Neoplasms
(therapy)
- Humans
- Injections, Intra-Arterial
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(surgery)
- Squamous Cell Carcinoma of Head and Neck
- Treatment Outcome
|