Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.
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Networked: 3805 relevant articles (59 outcomes, 293 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Gambhir, Sanjiv S: 17 articles (09/2012 - 03/2002)
2. Curiel, David T: 16 articles (11/2013 - 11/2002)
3. Nishikawa, Makiya: 16 articles (09/2013 - 11/2004)
4. Lang, Florian: 15 articles (01/2015 - 08/2009)
5. Burbelo, Peter D: 14 articles (02/2015 - 01/2008)
6. Hashida, Mitsuru: 13 articles (09/2013 - 11/2004)
7. Chen, Xiaoyuan: 13 articles (06/2013 - 11/2006)
8. Wang, Lei: 11 articles (12/2014 - 03/2008)
9. Yamashita, Fumiyoshi: 11 articles (09/2013 - 11/2004)
10. Iadarola, Michael J: 11 articles (01/2012 - 01/2008)

Related Diseases

1. Neoplasms (Cancer)
2. Infection
3. Anoxia (Hypoxia)
4. Neoplasm Metastasis (Metastasis)
5. Breast Neoplasms (Breast Cancer)
10/01/2015 - "In the present study, miR-205 was significantly downregulated in breast cancer samples and it was identified to directly target the 3'-untranslated region (3'-UTR) of AMOT in breast cancer MCF-7 cells by luciferase assay. "
12/01/2013 - "The present study investigated the total estrogenic activity of fruits and vegetables by calculating the 17-β-estradiol equivalent quantity (EEQ) using two in vitro tests: the human breast cancer cell line (MCF-7 BUS) proliferation assay (E-screen test) and the luciferase-transfected human breast cancer cell line (MELN) gene-reporter assay. "
06/01/2012 - "The aim of this study was to establish a bioluminescent MDA-MB-231 cell line stably expressing luciferase and green fluorescent protein for the generation of a xenografted model of human triple-negative breast cancer (TNBC) in nude mice. "
03/06/2007 - "In comparison, the interaction of hGH with the same receptor ECD did not demonstrate any significant dependence on pH. We also present an initial investigation of the pH dependence of hPRL function in rat Nb2 cell proliferation assays and a STAT5 luciferase gene reporter assay in the T47D human breast cancer cell line, whose results are consistent with our biophysical studies. "
05/01/2001 - "MDA-MB-435 breast cancer cells (435/Bcl-x(L)), which overexpress the Bcl-x(L) gene, were labeled with the luciferase gene and injected orthotopically into homozygous athymic Balb/c (nude) mice to study the metastatic behavior of the breast cancer cells. "

Related Drugs and Biologics

1. Small Interfering RNA (siRNA)
2. Proteins (Proteins, Gene)
3. docetaxel (Taxotere)
4. Carbon Monoxide
5. Messenger RNA (mRNA)
6. Thymidine Kinase
7. NF-kappa B (NF-kB)
8. Antigens
9. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10. beta-Galactosidase (Lactaid)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Drug Therapy (Chemotherapy)
3. Transplantation (Transplant Recipients)
4. Intravenous Injections
5. Immunotherapy