HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Concanavalin A affinity of alpha-fetoprotein. Its use in differentiating tumors.

AbstractUsing affinity chromatography on concanavalin A Sepharose, the authors studied the molecular heterogeneity of the serum alpha-fetoprotein of 53 patients with hepatocellular carcinoma, 16 patients with metastatic tumors to the liver, and 16 patients with germ cell tumors. Mean concanavalin binding of alpha-fetoprotein in the sera of patients with hepatocellular carcinoma was 79%, whereas the mean binding in metastatic tumors was 52% and that of germ cell tumors was 45%. This striking molecular variation of the alpha-fetoprotein produced by these different tumors is helpful in the clinical distinction of these tumors.
AuthorsS Govindarajan, T L Fong, M Ashcavai (Affiliation: Department of Pathology, University of Southern California, Downey.)
JournalAmerican journal of clinical pathology (Am J Clin Pathol) Vol. 88 Issue 6 Pg. 722-4 (Dec 1987) ISSN: 0002-9173 [Print] UNITED STATES
PMID2446494 (Publication Type: Journal Article)
Chemical References
  • alpha-Fetoproteins
  • Concanavalin A
Topics
  • Carcinoma, Hepatocellular (diagnosis)
  • Chromatography, Affinity
  • Concanavalin A (diagnostic use)
  • Diagnosis, Differential
  • Humans
  • Liver Neoplasms (diagnosis)
  • Male
  • Testicular Neoplasms (diagnosis)
  • alpha-Fetoproteins (blood, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password:


Research Interface PRO additionally includes drill-down to evidence, articles by author, export to Excel, FDA Link and mobile subscription:
1 year subscription, $45.00 USD