CEACAM1 Protein

A cell adhesion protein that is cross-reactive with CARCINOEMBRYONIC ANTIGEN, involved in regulating VEGFR2 signaling pathway and insulin functions. Also, play a role as coinhibitory receptor in immune response and as an activator during angiogenesis.

Also Known As:

C-CAM protein; C-CAM1; CEACAM1; 105, Cell-CAM; 105, CellCAM; A, Biliary Glycoprotein; Antigen, CD66a; C CAM protein; C CAM1; CEA Related Cell Adhesion Molecule 1; Carcinoembryonic Antigen Related Cell Adhesion Molecule 1; Cell CAM 105; Glycoprotein A, Biliary; Glycoprotein I, Biliary; I, Biliary Glycoprotein; Nonspecific Cross Reacting Antigen 160; Protein, CEACAM1; protein, C-CAM; Biliary Glycoprotein A; Biliary Glycoprotein I; CD66a Antigen; CEA-Related Cell Adhesion Molecule 1; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1; Cell-CAM 105; CellCAM 105; Nonspecific Cross-Reacting Antigen 160

Networked: 444 relevant articles (12 outcomes, 80 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Najjar, Sonia M: 34 articles (04/2022 - 01/2002)
2.	Shively, John E: 33 articles (01/2022 - 01/2003)
3.	Singer, Bernhard B: 23 articles (11/2022 - 06/2005)
4.	Beauchemin, Nicole: 20 articles (01/2020 - 06/2006)
5.	Wagener, Christoph: 20 articles (10/2018 - 02/2002)
6.	Ghadieh, Hilda E: 15 articles (04/2022 - 11/2015)
7.	Muturi, Harrison T: 15 articles (04/2022 - 01/2013)
8.	Blumberg, Richard S: 15 articles (01/2020 - 02/2002)
9.	Russo, Lucia: 14 articles (01/2021 - 08/2013)
10.	Heinrich, Garrett: 12 articles (01/2018 - 09/2008)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2015 - "Moreover, this inhibitory mechanism in many cases might hinder the efficacy of immunotherapeutic treatments of CEACAM1 malignancies because of tumor evasion by activated effector cells. " 03/01/2020 - "In the present study, we examined CEACAM1 expression and its association with patient survival in various cancers by analysis of multiple databases. " 03/01/2017 - "The aim of this study is to determine the expression of CEACAM1 in oral tumors, trying to study CEACAM1 different expressions as a function of histotype. " 02/01/2016 - "The aim of this study is to determine the expression of CEACAM1 in ovarian tumors, trying to see whether CEACAM1 has different expression patterns as a function of histotype. " 06/01/2008 - "Recent studies have challenged the previously postulated concept of a tumor-suppressive effect of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1). "
2.	Neoplasm Metastasis (Metastasis) 11/28/2017 - "Human CRC patients exhibiting high CEACAM1 in combination with low EPHA2 expression benefited from longer time to first recurrence/metastasis compared to those with high EPHA2 expression. " 02/18/2009 - "CEACAM1, L1, and HPA-binding site expression, all markers predicting metastasis in clinical studies, were preserved in the metastatic nodules. " 04/04/2023 - "Between the two subtypes, three upregulated genes, POP4, HEY1, CERKL, and seven downregulated genes, CEACAM1, ABLIM1, LTBP2, ISLR, LRRC32, PTPRF, and GPX3, associated with OS metastasis were found to be differentially regulated. " 01/01/2018 - "Our results suggest that CEACAM1 might be an independent favorable prognostic marker in OvCa, especially in the subgroup of patients with solely intraperitoneal metastasis." 11/28/2017 - "With the added interaction of CEACAM6, we denoted that CEACAM1 high- and EPHA2 low-expressing patient samples with lower CEACAM6 expression also exhibited a longer time to first recurrence/metastasis. "
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2015 - "Co-blockade of CEACAM1 and TIM-3 leads to enhancement of anti-tumour immune responses with improved elimination of tumours in mouse colorectal cancer models. " 02/01/2017 - "To investigate the expression of TIM-3 and CEACAM1 on circulating CD8+ T cells and tumor infiltrating lymphocytes (TILs), 65 diagnosed colorectal cancer (CRC) patients and 38 healthy controls were enrolled in this study and the results showed that TIM-3 and CEACAM1 were both highly expressed on circulating CD8+ T cells in CRC patients and elevated on TILs compared with paraneoplastic T cells. " 09/15/2011 - "The aim of our study was to clarify the implication of CEACAM1 re-expression in colorectal cancer. " 02/01/2017 - "Co-expression of TIM-3 and CEACAM1 promotes T cell exhaustion in colorectal cancer patients." 09/15/2011 - "Re-expression of CEACAM1 is observed at the invasion front of colorectal cancer. "
4.	Prostatic Neoplasms (Prostate Cancer) 05/01/2004 - "Our studies show that transcriptional repression by Sp2 represents one mechanism by which CEACAM1 tumor suppressor gene is down-regulated in prostate cancer." 01/01/2020 - "This demonstrated that the combined loss of Ceacam1 and Pten advanced prostate cancer by increasing lipogenesis and modifying the STAT3-dependent inflammatory microenvironment of prostate." 01/01/2020 - "Loss of Ceacam1 promotes prostate cancer progression in Pten haploinsufficient male mice." 01/01/2020 - "Loss of the adhesion molecule CEACAM1 is associated with early biochemical recurrence in TMPRSS2:ERG fusion-positive prostate cancers." 01/01/2013 - "Since prostate cancer often involves loss of epithelial lumen formation, we hypothesized that CEACAM20 and CEACAM1 play important roles in lumen formation of normal prostate epithelium. "
5.	Breast Neoplasms (Breast Cancer) 10/01/2015 - "Taken together, our results demonstrate a systematic down-regulation of CEACAM1 in breast cancer and suggest that a strategy to restore CEACAM1 expression may be helpful for the treatment of breast cancer." 10/01/2017 - "The present study aimed to identify whether CEACAM1 is involved in breast cancer development and to investigate the underlying mechanisms. " 10/01/2015 - "The aim of this study was to investigate CEACAM1 expression in breast cancer in greater detail. " 01/01/2019 - "Gene expression analysis after coculture revealed simultaneous induction of PD-L1, IDO1, CEACAM1, and further immunoregulatory checkpoints in breast cancer cells. " 10/15/2017 - "CEACAM1 transfection into breast cancer cells restores lumen formation in a 3D culture model. "

Related Drugs and Biologics

1.	Cell Adhesion Molecule-1
2.	Carcinoembryonic Antigen
3.	Proteins (Proteins, Gene)
4.	Antigens
5.	Messenger RNA (mRNA)
6.	Immunoglobulins (Immunoglobulin)
7.	Mucins
8.	Cancer Vaccines
9.	Transferrin Receptors (Transferrin Receptor)
10.	Azoxymethane

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Radiotherapy
4.	Hepatectomy
5.	Transplantation