Glutathione Peroxidase GPX1

One of the most abundant isoenzymes of the glutathione peroxidase family. Located in the cytosol and mitochondria, it catalyzes the reduction of HYDROGEN PEROXIDE to water, functioning to limit the accumulation of hydrogen peroxide and modulating processes that utilize hydrogen peroxide; and also the reduction of other organic hydroperoxides to their corresponding alcohols.

Also Known As:

Networked: 211 relevant articles (5 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Diamond, Alan M: 5 articles (09/2014 - 06/2003)
2.	Gao, Xiang: 3 articles (05/2022 - 06/2010)
3.	Bednarski, Patrick J: 3 articles (12/2021 - 01/2020)
4.	Cheng, Wen-Hsing: 3 articles (01/2021 - 04/2003)
5.	Wang, Hongrong: 3 articles (01/2021 - 02/2019)
6.	Zhang, Hao: 3 articles (01/2021 - 02/2019)
7.	Baş, Yalçın: 3 articles (08/2016 - 04/2014)
8.	Kalkan, Göknur: 3 articles (08/2016 - 04/2014)
9.	Seçkin, Havva Yıldız: 3 articles (08/2016 - 04/2014)
10.	King, Irena B: 3 articles (03/2012 - 01/2011)

Related Diseases

1.	Neoplasms (Cancer) 05/23/2022 - "Glutathione Peroxidase GPX1 and Its Dichotomous Roles in Cancer." 07/16/2021 - "Pentathiepins are polysulfur-containing compounds that exert antiproliferative and cytotoxic activity in cancer cells, induce oxidative stress and apoptosis, and inhibit glutathione peroxidase (GPx1). " 01/01/2020 - "Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells." 12/16/2019 - "Glutathione peroxidase 1 (GPX1) has been identified to be highly expressed in a variety of human malignancies. " 01/01/2018 - "There was highly significant positive correlation between SOD1 and glutathione peroxidase (GPX1) values postoperatively (r=0.67, p<0.001) and a trend for an inverse correlation between the individual values of the NRS24 and plasma SOD1 values postoperatively in patients with benign disease and those with cancer (r=-0.30, p=0.09). "
2.	Osteoporosis 01/01/2010 - "Glutathione peroxidase 1 (GPX1) is one of antioxidant enzymes responsible for the defence of cells against oxidative damage and thus for protection against age related diseases such as osteoporosis. " 10/01/2022 - "The present study focused on mapping polymorphism in an important antioxidant enzyme glutathione peroxidase 1 (GPx1) among osteoporosis and healthy Asian Indians. " 10/01/2022 - "Polyalanine polymorphism in the signal peptide of Glutathione peroxidase 1 (GPX1) gene & its association with osteoporosis."
3.	Hypoxia (Hypoxemia) 06/01/2010 - "Glutathione peroxidase 1 protects mitochondria against hypoxia/reoxygenation damage in mouse hearts." 01/01/2021 - "Expression of oxidative stress marker and contraction-related genes, Hypoxia-inducible factor 1-alpha (Hif1a), glutathione peroxidase 1 (Gpx1), Ras homolog family member A (RhoA), and Rho-associated protein kinase (Rock), was significantly increased in such repeated contraction/relaxation. " 01/01/2016 - "Expression of hypoxia-inducible factors Hif-1α and Hif-2α and of oxidative stress markers heme oxygenase-1 (Hmox1), glutathione peroxidase 1 (Gpx1), superoxidase dismutase 1 and 2 (Sod1, Sod2), and catalase was evaluated by qRT-PCR. " 02/01/2012 - "Compared with the LL group, the mRNA abundance of hypoxia-inducible factor 1α (HIF-1α) and thioredoxin-2 (Trx2) in the maternal liver and glutathione peroxidase 1 (GPx1) in the placenta and fetus were significantly downregulated in the HL group (p < 0.05). " 01/01/2023 - "Herein, we present a hypoxia-coordinated H2O2 regulatory mechanism whereby excess H2O2 in glioblastoma induced by hypoxia is diminished by glutathione peroxidase 1 (GPx1), an antioxidant enzyme detoxifying H2O2, via the binding of hypoxia-inducible factor-1α (HIF-1α) to GPx1 promoter. "
4.	Necrosis 04/01/2003 - "Previous research has suggested that repletion of cellular glutathione peroxidase (GPX1) activity by a single injection of Se was dissociated from the Se protection against the pro-oxidant-induced liver necrosis in Se-deficient rodents. " 01/06/2023 - "Seven genes are considered potential candidate genes for regulating antioxidant activity, including selenoprotein W, 1, glutathione peroxidase 1, glutathione S-transferase A1, tumour necrosis factor, tumour necrosis factor superfamily member 10, tumour necrosis factor superfamily member 8, and tumour necrosis factor superfamily member 13b. " 06/01/2013 - "Gilthead sea bream larvae (Sparus aurata) aged 47 days post hatching (dph) (11.6-12.8 mg in wet weight) were exposed to several sublethal concentrations of Cd(2+) (0.1, 5 and 10 mg/L) during 6 days in order to investigate the effects of this heavy metal on the expression of selected genes involved in detoxification (metallothionein-mt, glutathione peroxidase 1-gpx1), stress response (heat shock protein 70-hsp70, tumour necrosis factor α-tnfα) and ossification (osteocalcin-oc) processes. " 12/01/2015 - "We examined kidney-specific mRNA expression of genes related to endogenous antioxidant enzyme activity (glutathione peroxidase 1; Gpx1, superoxide dismutase 1; Sod1, and catalase; Cat) and inflammation (kidney injury molecule 1; Kim1 and tumour necrosis factor receptor super family 1b; Tnfrsf1b), as well as plasma F2-isoprostanes, a marker of lipid peroxidation. " 11/01/2016 - "Increase in IL-6, IL-10 and tumour necrosis factor alpha (TNF-α) with accompanying decrease in apolipoprotein A1, high-density lipoprotein (HDL) cholesterol, selenium, zinc, albumin, paraoxonase 1 and glutathione peroxidase 1 activity appeared at S1 and persisted until R7. "
5.	Atherosclerosis 03/01/2004 - "Atherosclerosis, oxidative stress and glutathione peroxidase-1: a new kid on the block." 08/01/2015 - "Ebselen, a glutathione peroxidase 1 (GPX1) mimic, has been shown to improve β-cell function in diabetes and prevent atherosclerosis. " 09/16/2011 - "Compared with deficiency of glutathione peroxidase 1 or catalase, Prdx2 deficiency showed a severe predisposition to develop atherosclerosis. " 02/15/2009 - "Glutathione peroxidase 1 (GPX-1) has an important role in antioxidant defense and has been suggested to have a protective role against the pathogenesis of atherosclerosis. "

Related Drugs and Biologics

1.	Antioxidants
2.	Enzymes
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	Malondialdehyde (Propanedial)
5.	Glutathione (Reduced Glutathione)
6.	Oxidoreductases (Dehydrogenase)
7.	Peroxiredoxins
8.	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)
9.	Ubiquitin
10.	Lysine (L-Lysine)

Related Therapies and Procedures

1.	Cholecystectomy
2.	Laparoscopic Cholecystectomy
3.	Kidney Transplantation
4.	Intraperitoneal Injections