Reinjuries

Damage inflicted on the same body part as a previous injury.

Also Known As:

Injury, Repeat; Injury, Second; Injury, Subsequent; Re-injury; Reinjury; Repeat Injury; Repeated injury; Second Injury; Subsequent Injury; injuries, Repeated; Re-injuries; Repeat Injuries; Repeated injuries; Second Injuries; Subsequent Injuries

Networked: 581 relevant articles (28 outcomes, 56 trials/studies)

Relationship Network

Disease Context: Research Results

Wounds and Injuries: 176426
- Reinjuries: 581

Related Diseases

1.	Kinesiophobia
2.	Ankle Injuries (Ankle Injury)
3.	Wounds and Injuries (Trauma)
4.	Sprains and Strains (Sprain)
5.	Spinal Cord Injuries (Spinal Cord Injury)

Experts

1.	Webster, Kate E: 6 articles (08/2021 - 11/2012)
2.	Feller, Julian A: 5 articles (08/2021 - 11/2012)
3.	Ebert, Jay R: 4 articles (01/2022 - 09/2018)
4.	Joss, Brendan: 4 articles (01/2022 - 09/2018)
5.	Banzer, Winfried: 4 articles (11/2021 - 08/2019)
6.	Niederer, Daniel: 4 articles (11/2021 - 08/2019)
7.	Dugan, Elizabeth: 3 articles (05/2022 - 01/2022)
8.	Pino, Elizabeth C: 3 articles (05/2022 - 01/2022)
9.	Witvrouw, Erik: 3 articles (10/2021 - 08/2016)
10.	Queen, Robin M: 3 articles (06/2021 - 12/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Reinjuries:

1.	HydrogelsIBA 01/01/2018 - "Finally, the efficacy of the mXG/HBC composite hydrogel in the prevention of recurrent adhesion was evaluated in a more rigorous rat repeated-injury adhesion model. " 06/01/2023 - "Injectable hydrogels are being researched as therapeutic agents because they may imitate numerous properties of CNS tissues and hence reduce subsequent injury and regenerate neural tissue. " 01/01/2022 - "In addition, the hydrogels could also entirely cover and firmly attach wounds with irregular shapes, so as to reduce the re-injury rate. " 12/01/2020 - "However, the currently available hydrogel dressings still need surgical or mechanical debridement from the wound, causing reinjury of the newly formed tissues, wound infection, delayed healing time, and personal suffering. " 12/14/2016 - "Improving Antiadhesion Effect of Thermosensitive Hydrogel with Sustained Release of Tissue-type Plasminogen Activator in a Rat Repeated-Injury Model."
2.	Proteins (Proteins, Gene)FDA Link 03/01/2017 - "Cautioning against this, however, is the association between muscle matrix protein remodeling and protection against reinjury, which suggests that a (so far undefined) period of vulnerability to reinjury may exist during the remodeling phases. " 01/01/2023 - "It is thought that the promotion of autophagy flux prevents host cells from subsequent injuries by removing damaged organelles and misfolded proteins. " 01/01/2016 - "These results suggest that axons downregulate protein synthetic capacity as they cease growing, yet they retain the ability to upregulate PSM after a second injury." 09/01/2014 - "Chronic stress or repeated injury in a particular organ induces abnormal molecular signals that lead to super-activation of matrix protein producing fibroblasts, excessive matrix proteins accumulation, loss of physiological tissue architecture or elasticity, and ultimately leading to organ failure. " 12/01/2012 - "It is possible that the repeated increase in vWF and constant degradation by ADAMTS-13 results in lower overall levels of both proteins in smokers (at rest) compared to nonsmokers who do not experience a similar (repeated) injury to the endothelium."
3.	CholesterolIBA 07/26/1996 - "Male miniswine with moderately elevated serum cholesterol levels underwent cardiac catheterization and oversized balloon injury to the right and left circumflex coronary arteries, followed 2 weeks later by repeat injury on the same coronary segments. " 01/01/1998 - "This study suggests that repeated injury and longer cholesterol feeding to increase percent stenosis may not be cost effective in this model. " 01/01/2020 - "We measured seven SHC: fatigue, spasticity, pain, pressure ulcers, subsequent injury, fracture, and anxiety disorder, and measured seven CHC: diabetes, heart attack, coronary artery disease, stroke, cancer, hypertension, and high blood cholesterol. "
4.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 07/01/2015 - "Very low-quality evidence showed a similar lack of difference between the two groups applied to swelling at day 3 (reported in two studies) and at day 7 (reported in two studies), in return to function at day 7 (89 participants, 1 study), and in gastrointestinal adverse events (141 participants, 3 studies).No studies compared NSAIDs with complementary and alternative medicines, and no study reported re-injury rates. " 10/08/1999 - "NSAIDs delay, but do not prevent the inflammatory response in injured tissue and may expose athletes to an increased risk of re-injury by delaying healing. " 03/01/2004 - "Finally, the combination of a COX-2 inhibitor with a PPI has shown promise in patients with previous NSAID-related gastrointestinal complications who are at high risk for reinjury."
5.	CytokinesIBA 02/07/2023 - "In mice, eyes that had been exposed to corneal epithelial injury exhibited faster re-epithelialization of the cornea and lower levels of inflammatory cytokines following subsequent injury (either the same or a different type of injury) relative to naïve eyes without previous injury. " 01/01/2021 - "A repeated injury of lung epithelial cells prompts type II alveolar cells to secrete pro-fibrotic cytokines, which induces differentiation of resident mesenchymal stem cells into myofibroblasts, thus promoting aberrant deposition of extracellular matrix (ECM) and formation of fibrotic lesions. " 09/01/2007 - "The mechanisms by which an initial injury primes the subject, exacerbating the responses to a second injury, remain unclear; however, inflammatory cytokines have been implicated. " 07/01/2019 - "Thus, supplemental zinc has a favourable consequence in restricting the compromised intestinal health in diabetes which was exerted through a defensive stimulus on oxidative stress induced cytokines, inflammatory propagation, and subsequent injury." 05/01/2013 - "Subsequent injuries were assessed by liver function analysis, qRT-PCR for chemokine and cytokine expression, liver tissue Western blot, histology and TUNEL assay. "
6.	Hyaluronic Acid (Hyaluronan)IBA 01/01/2019 - "Combined with UVB exposure, repeated injuries to the hyaluronan coat could maintain a sustained inflammatory state associated with melanomagenesis." 09/01/2007 - "Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated-injury model." 07/31/2007 - "In summary, budesonide in a hyaluronan hydrogel is easy to use and highly effective in preventing adhesions in our severe repeated injury model. " 11/21/2016 - "Peritoneal adhesion prevention with a biodegradable and injectable N,O-carboxymethyl chitosan-aldehyde hyaluronic acid hydrogel in a rat repeated-injury model." 07/01/2004 - "To determine whether intralesional injection of hyaluronan, beta aminoproprionitrile fumarate (BAPN) or polysulphated glycosaminoglycans (PSGAG) or systemic administration of PSGAG yielded better results than a controlled exercise programme alone in the management of SDF tendonitis, with a minimum follow-up period of 2 years after resumption of full work; and to determine whether reinjury rate was related to sports discipline and whether fibre alignment score (FAS) at 4 months could predict outcome. "
7.	Pain-FreeIBA 01/01/2018 - "The efficacy of treatments will be compared with respect to the outcomes 1) time to pain-free activity and 2) risk of subsequent injury. " 02/01/2020 - "Two reinjuries occurred in both the pain-free and pain-threshold groups between RTP clearance and the 6-month follow-up. " 01/01/2020 - "Meeting the clinically pain-free criteria resulted in fewer reinjuries compared with not meeting the criteria." 06/28/2019 - "Two re-injuries occurred in both the pain-free and pain-threshold group during six-month follow-up. " 02/01/2020 - "Secondary aims were to compare isometric knee flexor strength, biceps femoris long head (BFLH) fascicle length, fear of movement, and reinjury occurrence at the 6-month follow-up between pain-free and pain-threshold groups. "
8.	Sodium Glutamate (Accent)IBA 06/01/2000 - "Foreign Accent Syndrome following a catastrophic second injury: MRI correlates, linguistic and voice pattern analyses." 11/15/2009 - "The threshold concentration of MSG for neuronal injury is 3 microM; (2) MSG only injures neurons with little effect on glial cells; (3) Boiling MSG does not affect its toxicity but the addition of Vitamin C provides significant protection against MSG toxicity; (4) Pretreatment of neurons with a low dose of MSG reduces subsequent injury by a large dose of MSG. "
9.	Dexamethasone (Maxidex)FDA LinkGeneric 05/01/2009 - "Dexamethasone showed protective effects by regulating the levels of NF-kappaB and relieved the second injury caused by the inflammatory cytokines in rat brain tissue after TBI." 09/01/2015 - "Thermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model."
10.	Bleomycin (Blenoxane)FDA LinkGeneric 01/01/2013 - "We tested the efficacy of amnion mesenchymal stem cells (AM-MSC), bone marrow MSC (BM-MSC) and human amniotic epithelial cells (hAEC) in C57BL/6 mice using a repeat dose bleomycin-induced model of lung injury that better reflects the repeat injury seen in lung diseases. " 02/01/2016 - "Whereas the chemokine receptor CXCR7, expressed on PCECs, acts to prevent epithelial damage and ameliorate fibrosis after a single round of treatment with bleomycin or hydrochloric acid, repeated injury leads to suppression of CXCR7 expression and recruitment of vascular endothelial growth factor receptor 1 (VEGFR1)-expressing perivascular macrophages. "

Therapies and Procedures

1.	Therapeutics 01/01/2022 - "Although intralesional mesenchymal stem cell (MSC) therapy has improved tissue architecture and reinjury rates, the mechanisms by which they promote repair are still being investigated. " 07/16/2010 - "Additionally, the importance of adding adjunctive therapies, specifically joint mobilizations and balance training have been shown to improve function and decrease the incidence of reinjury after a LAS. " 01/01/2023 - "Despite surgical reconstruction and extensive rehabilitation, reinjuries are common and disability levels are high, even years after therapy and return to activity. " 01/01/2022 - "Despite appropriate therapy, reinjury is estimated to occur in 50-65% of cases. " 09/23/2020 - "As a result, novel therapeutics are necessary to improve repair with the goal of decreasing leg lameness and potential reinjury. "
2.	Orthotic Devices (Orthosis) 10/01/1999 - "Shoulder pad and neck orthoses selection should be reviewed to ensure that the best protection against reinjury is used when the athlete returns to play. " 10/01/1989 - "Recent years have seen the introduction of a great many knee orthosis designs prescribed for protection against ligamentous injury or reinjury of the knee. " 07/01/2019 - "During the healing process, a custom-molded or prefabricated orthopedic support, known as an orthosis, may be used to support the injured area and prevent reinjury. " 09/01/1990 - "These results suggest that the semirigid orthosis may be more effective than taping in providing initial ankle protection and in guarding against ligamentous reinjury." 04/01/1997 - "Ankle orthoses are commonly used for protection against initial ankle sprain injuries and for protection against reinjury. "
3.	Anterior Cruciate Ligament Reconstruction 11/30/2023 - "Improved Patient-reported Outcomes in Patients Aged 16 and Younger at Two Years After Anterior Cruciate Ligament Reconstruction Despite Relatively High Rates of Reinjury and Repeat Surgery." 12/01/2004 - "Proportional hazard regression analyses adjusted for age, race, sex, marital status, education, and physical activity level confirmed that anterior cruciate ligament reconstruction was protective against meniscal and cartilage reinjury (P < .0001). " 01/01/2022 - "The purpose of this study was to determine whether fear of re-injury is manifested in joint kinematics and muscle activation patterns during landings of a standardized rebound side-hop (SRSH), or in patient-reported outcome measures (PROMs), among individuals with anterior cruciate ligament reconstruction (ACLR). " 11/01/2021 - "Acute effects of a neuromuscular warm-up on potential re-injury risk factors associated with unanticipated jump landings after anterior cruciate ligament reconstruction: A crossover trial." 08/13/2019 - "Effectiveness of a home-based re-injury prevention program on motor control, return to sport and recurrence rates after anterior cruciate ligament reconstruction: study protocol for a multicenter, single-blind, randomized controlled trial (PReP)."
4.	Reoperation 07/01/2023 - "Failure was defined as (1) reinjury, recurrent instability, or need for revision surgery; (2) failure show improvement in postoperative patient-reported outcomes (PROs); or (3) failure to RTS at the preinjury level (RSL). " 07/01/2023 - "Of these 12 studies, 4 defined outcomes based on recurrent instability, reinjury, or revision surgery; 2 defined outcomes based on PROs; and 6 defined outcomes based on RSL. " 10/26/2023 - "Two (5%) collision/contact and 3 (12%) limited/noncontact athletes had traumatic reinjury requiring revision surgery. " 11/01/2021 - "Regarding the outcome of re-injury, no statistically significant differences were found between subgroups of athletes vs non-athletes or primary injury vs revision surgery, despite a significant tendency towards increased re-injury levels in athletes. " 09/01/2021 - "All patients a had follow-up MRI on postoperative day 1. Patients with revision surgery and those with reinjury after reconstruction were excluded. "
5.	Exercise Therapy (Therapy, Exercise) 01/01/2022 - "Furthermore, we found evidence supporting the effectiveness of manipulative and supervised exercise therapy to prevent re-injury and restore ankle dorsiflexion." 01/01/2019 - "Insufficient exercise therapy or incomplete rehabilitation, premature return-to-sport and re-injury, unrealistic expectations, or poor nutrition may further elevate this risk. " 01/01/2019 - "Rehabilitation Exercises Reduce Reinjury Post Ankle Sprain, But the Content and Parameters of an Optimal Exercise Program Have Yet to Be Established: A Systematic Review and Meta-analysis." 04/15/2010 - "Psychomotor therapy improved functional disability, self-efficacy, outcome expectancy, and fear of movement/(re)injury significantly more than exercise therapy at respective follow-up occasions. " 01/01/2018 - "Early mobilization improves recovery from ankle sprains, and exercise therapy and functional bracing while running for six to 12 months prevents reinjury. "