Hyaluronic Acid (Hyaluronan)

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3426 relevant articles (201 outcomes, 482 trials/studies) found for this Bio-Agent

Description: A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.

Also Known As:

Hyaluronan; Advanced Medical Optics Brand of Sodium Hyaluronidate; Advanced Medical Optics, Inc. Brand of Sodium Hyaluronate; Akorn, Inc. Brand of Sodium Hyaluronate; Amo Vitrax; Amvisc; Anika Therapeutics Brand of Sodium Hyaluronidate; Bausch and Lomb Brand of Sodium Hyaluronate; Biolon; Etamucine; Healon; Hyaluronate Sodium; Hyvisc; Luronit; Sodium Hyaluronate; Acid, Hyaluronic; Hyaluronate, Sodium; Vitrax, Amo; Hyaluronic acid

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 2945

Polysaccharides: 1669

Glycosaminoglycans: 2413

Hyaluronic Acid: 3426

Experts

1.	Toole, Bryan P: 14 articles (08/2008 - 02/2002)
2.	Kimata, Koji: 10 articles (09/2008 - 01/2004)
3.	Ghatak, Shibnath: 9 articles (05/2008 - 10/2002)
4.	Misra, Suniti: 8 articles (05/2008 - 10/2002)
5.	Itano, Naoki: 7 articles (09/2008 - 01/2004)
6.	Kosma, Veli-Matti: 7 articles (08/2008 - 02/2002)
7.	Hascall, Vincent C: 7 articles (04/2008 - 09/2002)
8.	Lokeshwar, Vinata B: 7 articles (01/2008 - 07/2002)
9.	Zhuo, Lisheng: 6 articles (09/2008 - 06/2005)
10.	Prestwich, Glenn D: 6 articles (09/2008 - 04/2005)

Related Diseases

1.	Osteoarthritis 04/03/2009 - "The results of these studies demonstrate that enhanced chondrocyte survival and improved mitochondrial function under conditions of oxidative injury are probably important therapeutic mechanisms for the actions of hyaluronic acid in osteoarthritis." 12/01/2008 - "RESULTS: Clinically affected dogs had significantly greater degrees of pathologic findings, compared with dogs with surgically induced osteoarthritis (ie, those with CrCLt, GR, and MR stifle joints), and with respect to lameness scores, radiographic signs of osteoarthritis, pathologic findings on arthroscopy, and synovial fluid hyaluronan concentration. " 10/01/2000 - "Is hyaluronic acid effective in patients with osteoarthritis of the knee?" 07/01/1992 - "Sodium hyaluronate (HA) with a molecular weight of approximately 600,000-1,200,000 is reportedly effective against osteoarthritis (OA). " 04/01/1989 - "The protective effects of hyaluronic acid suggest the potential clinical application of this therapy in retarding the advance of osteoarthritis." Order ALL the reference details at left...
2.	Pain (Aches) 09/01/2007 - "On the other hand, if patients were old and inactive with household ambulation, using intra-articular Sodium Hyaluronate was beneficial in improving pain, stiffness, and function but not ambulation level with 86.56% of excellent or good in overall satisfaction level. " 04/16/2009 - "CONCLUSION: Single application of high-viscosity hyaluronan shows superior range of motion and pain reduction as well as improvement in clinical results. " 01/01/1988 - "Pain on movement, assessed by visual analogue scale (VAS) showed statistically significant (p less than 0.05 to p less than 0.0001) reductions in mean scores throughout the first 11 weeks of treatment with sodium hyaluronate but smaller, non-significant, reductions with placebo treatment. " 08/01/2008 - "In the Sodium Hyaluronate group, pain improved from 6.6 to 5.7 at 6 weeks (p>0.05) and to 4.1 at 3 months (p=0.04) but was sustained only until 6 months (5.9, p>0.05). " 01/01/2002 - "CONCLUSION: Sodium hyaluronate appears effective in relieving post-operation pain of the knee joint." Order ALL the reference details at left...
3.	Knee Osteoarthritis 05/01/2003 - "The results showed that both intra-articular hyaluronic acid and 6-MPA treatments provide clinically significant improvement and demonstrated that Na HA has a long-term beneficial effect in patients with knee osteoarthritis." 09/01/2007 - "CONCLUSION: Intra-articular Sodium Hyaluronate injection, used in knee-osteoarthritis patients who failed conservative treatment, was effective in visible cartilage patients (Ahlback grade 1, 2) without mechanical problems involved. " 04/01/2004 - "Hyaluronic acid minimally effective for knee osteoarthritis." 08/01/2009 - "OBJECTIVE: To report the FLEXX trial, the first well-controlled study assessing the safety and efficacy of Euflexxa (1% sodium hyaluronate; IA-BioHA) therapy for knee osteoarthritis (OA) at 26 weeks. " 02/01/2006 - "The goal of this study was to assess the safety and efficacy of hyaluronan (HA) with/without corticosteroid in patients with knee osteoarthritis (OA). " Order ALL the reference details at left...
4.	Neoplasms (Cancer) 04/01/1993 - "A hyaluronic acid-supported complex was the most effective against the tumors (all six mice survived for 60 days). " 01/01/2005 - "A more complete understanding of the mechanisms whereby hyaluronan exerts its influences on cell behavior will enhance our understanding of normal and pathological EMTs and may lead to improved therapies for cancer patients." 10/01/2004 - "RESULTS: There were significantly greater increases in the growth and the weight of subcutaneous tumors in the sodium hyaluronate group compared with the control group. " 05/01/2002 - "Recent understanding of hyaluronan biology has benefited from the identification of genes encoding hyaluronan synthases and hyaluronidases, genetic analysis of the roles of hyaluronan during development, elucidation of the biochemical mechanisms of hyaluronan synthesis, and by studies of human genetics and tumors. " 12/18/2008 - "Here, we aimed to investigate the ability of non-animal stabilized hyaluronic acid (NASHA) to retain the anti-cancer drugs in the peritoneal cavity, and, consequently, improve the efficacy of i.p. " Order ALL the reference details at left...
5.	Vesico-Ureteral Reflux (Vesicoureteral Reflux) 10/01/2007 - "CONCLUSIONS: Endoscopic treatment with dextranomer/hyaluronic acid is safe and highly effective for eradicating high grade vesicoureteral reflux in infants. " 10/01/2006 - "Subureteral dextranomer/hyaluronic acid injection as first line treatment in the management of high grade vesicoureteral reflux." 08/01/2006 - "CONCLUSIONS: Endoscopic treatment with nonanimal stabilized hyaluronic acid/dextranomer gel is effective in a high proportion of children with vesicoureteral reflux and, in our opinion, may be considered as a first-line treatment option." 03/01/2007 - "CONCLUSIONS: Endoscopic treatment with stabilized nonanimal hyaluronic acid/dextranomer gel appears to be similarly effective in patients with vesicoureteral reflux with and without bladder dysfunction. " 03/01/2007 - "Endoscopic treatment with stabilized nonanimal hyaluronic acid/dextranomer gel is effective in vesicoureteral reflux associated with bladder dysfunction." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Hyaluronic Acid (Hyaluronan)
2.	dextranomer
3.	hylan
4.	Hyaluronoglucosaminidase (Hyaluronidase)
5.	Alanine Transaminase (SGPT)
6.	Laminin (Merosin)
7.	Paclitaxel (Taxol)
8.	Ophthalmic Solutions (Eye Drops)
9.	Methylcellulose (BFL)
10.	Dexamethasone (Maxidex)

Related Therapies and Procedures

1.	Intra-Articular Injections
2.	Injections
3.	Viscosupplementation
4.	Phacoemulsification
5.	Heterologous Transplantation (Xenotransplantation)

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