Zolpidem (Ambien)

An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.

Also Known As:

Ambien; Stilnox; Amsic; Bikalm; Dalparan; N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2a)pyridine-3-acetamide hemitartrate; SL 80.0750; SL-800750-23-N; Stilnoct; Zodormdura; Zoldem; Zolirin; Zolpi-Lich; Zolpidem 1A Pharma; Zolpidem AbZ; Zolpidem Hemitartrate; Zolpidem Tartrate; Zolpimist; Zolpinox; SL 800750 23 N; Zolpi Lich; Imidazo(1,2-a)pyridine-3-acetamide, N,N,6-trimethyl-2-(4-methylphenyl)-

Networked: 935 relevant articles (113 outcomes, 203 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 207
- 1-Ring Heterocyclic Compounds
  - Pyridines: 91
    - Zolpidem: 935
      - lorazepam drug combination zolpidem diphenhydramine

Experts

1.	Roth, Thomas: 17 articles (01/2019 - 03/2001)
2.	Krystal, Andrew D: 11 articles (12/2023 - 08/2004)
3.	Kao, Chia-Hung: 11 articles (03/2022 - 05/2012)
4.	Lin, Cheng-Li: 8 articles (03/2022 - 01/2015)
5.	Moline, Margaret: 7 articles (12/2024 - 02/2013)
6.	Morin, Charles M: 7 articles (12/2023 - 06/2014)
7.	Zammit, Gary: 7 articles (01/2023 - 06/2008)
8.	Clauss, R P: 7 articles (01/2017 - 01/2000)
9.	Sung, Fung-Chang: 7 articles (01/2015 - 05/2012)
10.	Walsh, James K: 7 articles (11/2010 - 10/2002)

Related Diseases

1.	Sleep Initiation and Maintenance Disorders (Insomnia) 01/01/2010 - "Zolpidem is clinically very effective in treating insomnia. " 12/01/2023 - "The REST-IT study found the addition of zolpidem-controlled release (CR) provided a significant reduction in observer-rated measurement of suicidal ideation (the Columbia Suicide Severity Rating Scale) in 103 depressed outpatients with insomnia and suicidal ideation, but without significant change in a self-report measure of suicidal ideation (the Scale for Suicide Ideation). " 08/01/2004 - "Over a period of 12 weeks of intermittent treatment with zolpidem, sleep continuity was significantly improved, the clinical gains were sustained, and there was no evidence of subjective rebound insomnia between doses or increases in the amount of medication used during the study interval." 10/01/2008 - "Employed adults with chronic insomnia treated with zolpidem extended-release 12.5 mg experienced significantly improved work performance over 24 weeks." 12/15/2000 - "In agreement with previous findings obtained in patients with chronic primary insomnia, zolpidem significantly improved sleep induction and maintenance. "
2.	Consciousness Disorders 10/01/2013 - "The present open-label study therefore failed to show any clinically significant improvement (i.e., change of Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study diagnosis) in any of the 60 studied chronic DOC patients." 09/01/2016 - "Poster 323 Efficacy of Intermittent Dosing of Zolpidem in Disorders of Consciousness: A Case Report." 10/01/2013 - "Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study." 05/01/2009 - "The objectives of this study were to obtain an estimate of the frequency of clinically significant responses among individuals with disorders of consciousness, to determine whether less obvious drug responses are present among "nonresponders," and to identify clinical features characteristic of zolpidem responders. " 05/01/2009 - "Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: a preliminary placebo controlled trial."
3.	Dystonia (Limb Dystonia) 01/01/2022 - "With zolpidem administration, the participants' Burke-Fahn-Marsden Dystonia Rating Scale-Movement Scale score significantly improved from 8.1 ± 6.7 to 3.7 ± 2.5 (50.6% improvement, p < 0.0001). " 01/01/2022 - "Although there are several reports of the significant efficacy of zolpidem for treating dystonia, zolpidem is still considered an anecdotal treatment. " 01/01/2012 - "Efficacy of zolpidem for dystonia: a study among different subtypes." 01/01/2012 - "In conclusion, our large scale study suggested that zolpidem may be a therapeutic option for dystonia, particularly post-traumatic dystonia." 01/01/2022 - "We retrospectively reviewed medical records from January 2021 to September 2021 to identify patients with dystonia who had been prescribed zolpidem after undergoing neurosurgery. "
4.	Persistent Vegetative State (Vegetative State) 10/01/2010 - "The aim of this study was to determine if zolpidem is associated with improved responsiveness or regional cerebral perfusion in patients with persistent vegetative states. " 01/01/2006 - "The long term efficacy of zolpidem in the permanent vegetative state is described in three patients. " 01/01/2014 - "To study the Zolpidem arousing effect in persistent vegetative state (PVS) patients combining clinical evaluation, autonomic assessment by heart rate variability (HRV), and EEG records. " 10/01/2010 - "Zolpidem for persistent vegetative state--a placebo-controlled trial in pediatrics." 12/01/2016 - "A single dose of zolpidem can transiently improve the level of consciousness in patients with vegetative state or minimally conscious state. "
5.	Sleep Wake Disorders 07/01/2002 - "With discontinuation of zolpidem and effective treatment of their sleep disorders, nocturnal eating resolved. " 09/01/2020 - "Comparative Efficacy of Zolpidem and Nigella Sativa in Treatment of Sleep Disorder and Vasomotor Symptoms in Menopausal Women of Women's General Hospital." 01/01/2015 - "This study identified 37,810 patients with anxiety or sleep disorder (mean age=53.2 years, SD=16.0 years) who had zolpidem prescribed for at least 2 months from January 1, 2000 through December 31, 2009. " 09/01/2015 - "Overall, patients with nonapnea sleep disorders using zolpidem had a higher risk of T2DM compared with patients not using zolpidem and the control cohort (adjusted hazard ratio [HR] = 1.41, 95% confidence interval [CI] = 1.35-1.48). " 01/01/2015 - "Is Zolpidem Associated with Increased Risk of Fractures in the Elderly with Sleep Disorders? "

Related Drugs and Biologics

1.	Hypnotics and Sedatives (Sedatives)
2.	Benzodiazepines
3.	imidazopyridine
4.	zaleplon (Sonata)
5.	Triazolam (Halcion)
6.	zopiclone (Zop)
7.	suvorexant
8.	Nitrazepam (Serenade)
9.	Eszopiclone (Lunesta)
10.	Trazodone (Trittico)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Continuous Positive Airway Pressure
4.	Self Administration (Administration, Self)
5.	Aftercare (After-Treatment)