Abstract | OBJECTIVE:
Zolpidem, a nonbenzodiazepine hypnotic, is very effective and widely prescribed in clinical practice for the treatment of insomnia and is thought to have few adverse effects. However, zolpidem-induced adverse effects have begun to be reported in the literature, but few systemic descriptions of the adverse effects (especially for psychotic reactions) of zolpidem have been undertaken. In light of the accumulating reports of adverse reactions to zolpidem, we present 2 case reports of zolpidem-induced adverse effects and review the literature on this subject. DATA SOURCES: Articles were selected by the authors on the basis of our experience and by a PubMed search using the terms zolpidem or side effects or adverse effects or adverse reactions. STUDY SELECTION AND DATA EXTRACTION: Publications relevant to the objective of this article were obtained (1992-2010), and some adverse neuropsychiatric reactions were summarized. DATA SYNTHESIS: CONCLUSIONS:
Zolpidem is clinically very effective in treating insomnia. However, while rare, zolpidem-induced unusual complex behavior may develop. Primary care physicians should be alert to the possible unusual complex adverse effects of zolpidem.
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Authors | Takuji Inagaki, Tsuyoshi Miyaoka, Seiichi Tsuji, Yasushi Inami, Akira Nishida, Jun Horiguchi |
Journal | Primary care companion to the Journal of clinical psychiatry
(Prim Care Companion J Clin Psychiatry)
Vol. 12
Issue 6
( 2010)
ISSN: 1555-211X [Electronic] United States |
PMID | 21494350
(Publication Type: Journal Article)
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